New pacemaker approach could reduce heart failure risk

NCT ID NCT05815745

Recruiting now Disease control Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 4 times

Summary

This study compares two pacemaker methods for people with a slow heart rate: standard right ventricular pacing and a newer 'physiological pacing' that targets the heart's natural conduction system. Researchers will track 2,600 participants over time to see which method better prevents death and heart failure. The goal is to find a safer long-term pacing option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pacemaker (physiological pacing or right ventricular pacing)
What this could lead to: If successful, this could show that physiological pacing reduces the risk of death and heart failure compared to standard pacing.
What could go wrong: This is a large trial, but results may not apply to all patients. The new pacing method is more complex and may have higher risks during implantation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation Bradycardia first-degree atrioventricular block Mobitz type I atrioventricular block Mobitz type II atrioventricular block third-degree atrioventricular block

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRADYCARDIA HIS BUNDLE PACING LEFT BUNDLE BRANCH AREA PACING PACING RIGHT VENTRICULAR PACING

Contacts and locations

Locations

Aberdeen Royal Infirmary
RECRUITING

Aberdeen, United Kingdom
Beacon Hospital
RECRUITING

Dublin, Ireland
Bristol Heart Institute
RECRUITING

Bristol, United Kingdom
Croydon
RECRUITING

Croydon, United Kingdom
Derriford Hospital
RECRUITING

Plymouth, United Kingdom
East Surrey
RECRUITING

Redhill, United Kingdom
Forth Valley Royal Hospital
RECRUITING

Larbert, United Kingdom
Glenfield Hospital
RECRUITING

Leicester, United Kingdom
Good Hope Hospital
RECRUITING

Birmingham, United Kingdom
Great Western
RECRUITING

Swindon, United Kingdom
Hammersmith Hospital
RECRUITING

London, United Kingdom
James Cook Hospital
RECRUITING

Middlesbrough, United Kingdom
John Radcliffe Hospital
RECRUITING

Oxford, United Kingdom
Kettering Hospital
RECRUITING

London, United Kingdom
King's College Hospital
RECRUITING

London, United Kingdom
King's Mill Hospital
RECRUITING

Nottingham, United Kingdom
Leeds Teaching Hospital
RECRUITING

Leeds, United Kingdom
Liverpool Heart and Chest Hospital
RECRUITING

Liverpool, United Kingdom
Medway Maritime Hospital
RECRUITING

Gillingham, United Kingdom
Morriston Hospital
RECRUITING

Swansea, United Kingdom
Musgrove Park Hospital
RECRUITING

Taunton, United Kingdom
Northern General
RECRUITING

Sheffield, United Kingdom
Nottingham City Hospital
RECRUITING

Nottingham, United Kingdom
Queen Alexandra Hospital
RECRUITING

Portsmouth, United Kingdom
Queen Elizabeth Hospital
RECRUITING

Birmingham, United Kingdom
Queen's Hospital
RECRUITING

Barking, United Kingdom
Rotherham General Hospital
RECRUITING

Rotherham, United Kingdom
Royal Berkshire
RECRUITING

Reading, United Kingdom
Royal Free London/ Barnet Hospital
RECRUITING

London, United Kingdom
Royal Infirmary of Edinburgh
RECRUITING

Edinburgh, United Kingdom
Royal Papworth Hospital
RECRUITING

Cambridge, United Kingdom
Royal SUSSEX County Hospital
RECRUITING

Brighton, United Kingdom
Southampton
RECRUITING

Southampton, United Kingdom
St Bartholomew's Hospital
RECRUITING

London, United Kingdom
St Richard's Hospital
RECRUITING

Chichester, United Kingdom
Torbay Hospital
RECRUITING

Torquay, United Kingdom
UHS Worthing
RECRUITING

Worthing, United Kingdom
Univerisity Medical Centre Ljubljana
RECRUITING

Ljubljana, Slovenia
University Hospital Coventry
RECRUITING

Coventry, United Kingdom
University Hospital Dorset
RECRUITING

Bournemouth, United Kingdom
Victoria Hospital
RECRUITING

Fife Keith, United Kingdom
Watford General Hospital
RECRUITING

London, United Kingdom
Wexham Park Hospital
RECRUITING

Slough, United Kingdom
Wycombe Hospital
RECRUITING

High Wycombe, United Kingdom
York Hospital
RECRUITING

York, United Kingdom

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