One procedure to replace lifelong blood thinners? new trial tests dual heart fix for stroke survivors

NCT ID NCT06212674

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a single procedure that combines two heart treatments—pulmonary vein isolation (to correct irregular heartbeat) and left atrial appendage occlusion (to block a clot-prone area)—can prevent future strokes and major bleeding better than standard blood thinners. The trial enrolls 240 adults who recently had a stroke and have atrial fibrillation. Participants are randomly assigned to the combined procedure, the occlusion procedure alone, or continued medication. The goal is to see if the combined approach is at least as effective as medication, with fewer bleeding risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Procedure: pulmonary vein isolation (PVI) plus left atrial appendage occluder (LAAO) implantation
What this could lead to
If successful, this combined procedure could offer a one-time treatment to reduce stroke risk and bleeding complications compared to lifelong blood thinners.
What could go wrong
This is a Phase 4 trial with 240 participants, so results are preliminary. The procedure carries risks like bleeding, infection, or device complications, and may not be superior to standard medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ATRIAL FIBRILLATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Silesian Center for Heart Disease

    RECRUITING

    Zabrze, Upper Silesia, 41-800, Poland

  • Upper-Silesian Medical Center

    RECRUITING

    Katowice, Upper Silesia, 40-635, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.