MRI-Guided heart procedure aims to stop dangerous rhythms

NCT ID NCT04694079

Completed Disease control Sponsor: Azienda Ospedaliero, Universitaria Pisana Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using cardiac MRI to guide ablation (a procedure that destroys small areas of heart tissue) can improve outcomes for people with ventricular tachycardia, a dangerous fast heart rhythm. 104 adults with structural heart disease were randomly assigned to one of three ablation approaches: MRI-guided, MRI-aided, or standard electroanatomical mapping. The goal was to see if MRI guidance reduces the return of abnormal rhythms and makes the procedure safer and more efficient.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cardiac magnetic resonance (CMR)-guided ablation procedure
What this could lead to: If successful, this approach could make heart ablation more precise and effective, reducing the chance of dangerous heart rhythms returning.
What could go wrong: This is a completed Phase 4 study with 104 participants, but results may not apply to all patients. The benefit of MRI guidance over standard methods is still uncertain.

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Conditions

The condition(s) this trial relates to.

endomyocardial fibrosis heart disorder ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOCARDIAL FIBROSIS VENTRICULAR TACHYCARDIA

Contacts and locations

Locations

AOUPisana

Pisa, PI, 56100, Italy
Azienda Ospedaliero Universitaria Senese - U.O.C. Cardiologia, Siena

Siena, SI, Italy
Azienda USL Toscana Nord Ovest - U.O.C. Cardiologia, Ospedale Versilia

Camaiore, LU, Italy
Azienda USL Toscana Nord Ovest- U.O.C. Cardiologia, Ospedali Riuniti - Livorno

Livorno, LI, 57126, Italy
Azienda USL Toscana Sud Est

Arezzo, AR, Italy
Azienda USL Toscana Sud Est- U.O.C. Cardiologia, Ospedale Misericordia - Grosseto

Grosseto, GR, Italy
FTGM

Pisa, PI, 56100, Italy

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