Which heart ablation works best? major trial pits cold vs heat
NCT ID NCT01490814
First seen Apr 25, 2026 · Last updated Apr 25, 2026
Summary
This study compared two ways to treat a common heart rhythm problem called paroxysmal atrial fibrillation (PAF). 769 adults who had symptoms and didn't get better with medication were randomly assigned to have either a cryoballoon (freezing) or radiofrequency (heating) catheter procedure to isolate the pulmonary veins. The goal was to see which method was safer and better at preventing the return of abnormal heart rhythms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Arrhythmia Unit Hospital Clinico San Carlos
Madrid, 28040, Spain
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Asklepios Klinik St. Georg
Hamburg, 20099, Germany
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CHU Lyon, Départment de Rythmologie, Hospital Cardiologique Pradel
Lyon, 69677, France
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Cardiac Arrhythmia Research Centre Department of Cardiovascular Medicine Centro Cardiologico Monzino University of Milan
Milan, 20138, Italy
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Cardioangiologisches Centrum Bethanien - CCB
Frankfurt, 60431, Germany
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Centre Chirurgical Ambroise Paré
Neuilly-sur-Seine, 92200, France
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Herz-Zentrum Bad Krozingen
Bad Krozingen, 79189, Germany
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Herz-Zentrum-Bodensee Konstanz
Konstanz, 78464, Germany
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Hospital Clinic, University of Barcelona
Barcelona, 08036, Spain
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Hospital Clinico Universtitario, Cardiology Department Arrhythmia Unit
Valencia, 46014, Spain
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Hospital Henri Mondor CHU, Service de Cardiologie
Créteil, 94010, France
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Hospital Universitario Virgen de la Victoria, Department of Cardiology, Campus Teatinos sn
Málaga, 29010, Spain
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Isala Klinieken loc. Weezenlanden Diagram Clinical Resarch
Zwolle, 8011, Netherlands
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Klinik für Kardiologie II mit interventioneller Elektrophysiologie
Bad Neustadt/Saale, 97616, Germany
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La Clinique Pasteur, 45 Avenue de Lombez
Toulouse, 31076, France
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Na Homolce Hospital, Cardiology
Prague, 515030, Czechia
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Semmelweis University of Medicine, Kardiovaskuläres Zentrum
Budapest, 1122, Hungary
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Universitätsklinikum Greifswald Elektrophysiologie
Greifswald, 17475, Germany
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Universitätsspital Basel, Elektrophysiologie/ Kardiologie
Basel, 4031, Switzerland
Conditions
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