Heart rhythm showdown: which ablation strategy wins for persistent AF?

NCT ID NCT05921734

Completed Disease control Sponsor: Shanghai Chest Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two ways to treat persistent atrial fibrillation (a type of irregular heartbeat) using catheter ablation. In one group, doctors aimed to stop the abnormal rhythm during the procedure. In the other, they followed a preset plan and used electrical shock if needed. The trial included 480 adults having their first ablation. The goal was to see which approach led to fewer heart rhythm problems over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: catheter ablation procedure
What this could lead to: If successful, this could help doctors choose the best ablation approach to reduce irregular heart rhythms in people with persistent atrial fibrillation.
What could go wrong: The trial is completed but results are not yet widely published. Ablation carries risks like bleeding, infection, or heart damage, and the best strategy may still depend on individual patient factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION CATHTER ABLATION ENDPOINT

Contacts and locations

Locations

Mu Qin

Shanghai, 200030, China
Shanghai Chest Hospital

Shanghai, China

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