New heart procedure aims to stop persistent AFib without pills
NCT ID NCT03643224
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a device called the DiamondTemp system, which uses heat energy to destroy tiny areas of heart tissue causing irregular heartbeats in people with persistent atrial fibrillation. 376 adults with drug-resistant symptoms took part. The goal was to see if the procedure could safely restore normal rhythm for at least a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Radiofrequency ablation catheter (DiamondTemp system)
- What this could lead to
- If successful, this could provide a safe and effective way to control persistent atrial fibrillation and reduce symptoms without long-term medication.
- What could go wrong
- This is a completed trial, but results may not apply to all patients. Risks include serious side effects like heart damage or stroke. The procedure may not permanently fix the condition.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Advent Health, Florida Hospital Orlando
Orlando, Florida, 32751, United States
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CHRU Nancy
Nancy, 54511, France
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Centro Cardiologico Monzino
Milan, Milano, 20138, Italy
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Clinique Pasteur
Toulouse, 31076, France
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Clinique Saint Pierre
Perpignan, 66000, France
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Clinique du Tonkin
Villeurbanne, Lyon, 69100, France
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Grandview Medical Center
Birmingham, Alabama, 35242, United States
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Institut Klinicke a Experimentalni Mediciny (IKEM)
Prague, Czechia, 14021, Czechia
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Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ)
Québec, Quebec, G1V4G5, Canada
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Iowa Heart Center
West Des Moines, Iowa, 50266, United States
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Jackson Heart Clinic
Jackson, Mississippi, 39216, United States
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Kansas City Heart Rhythm Institute
Overland Park, Kansas, 66211, United States
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Keck School Of Medicine
Los Angeles, California, 90033, United States
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Leipzig Heart Institute GmbH
Leipzig, 04289, Germany
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Medical University Of South Carolina
Charleston, South Carolina, 29425, United States
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Montefiore Medical Center
New York, New York, 10467, United States
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Montreal Heart Institute
Montreal, Quebec, HITC8, Canada
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Na Homolce
Prague, Prague, 15000, Czechia
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North Mississippi Medical Center
Tupelo, Mississippi, 38801, United States
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Ospedale dell'Angelo
Venezia, 30174, Italy
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Southlake Regional Health Center
Newmarket, Ontario, L3Y2P6, Canada
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St Ann's University Hospital
Brno, 65691, Czechia
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Texas Cardiac Arrhythmia Research Foundation
Austin, Texas, 78705, United States
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Trident Medical Center
Charleston, South Carolina, 29406, United States
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University Of Alabama
Birmingham, Alabama, 35294, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A tiny neck implant could catch Stroke-Causing clots before they reach the brain
- Could a new injection tame atrial fibrillation?
- Which blood thinner is safer for heart patients? a Head-to-Head test
- Can a cholesterol drug keep atrial fibrillation at bay after ablation?
- Can a One-Two punch fix a leaky heart valve and restore normal rhythm?
- Could a guided Self-Care plan tame atrial Fibrillation's return?