Personalized heart ablation may beat standard procedure for AFib
NCT ID NCT04702451
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether a tailored ablation approach, which targets specific abnormal areas in the heart, works better than the standard anatomical ablation for people with persistent atrial fibrillation (AFib). 377 adults with AFib that didn't respond to medication were included. The tailored method uses a special mapping system to find and burn problem spots, while the standard method only isolates the pulmonary veins. The main goal was to see who stayed free of AFib for 12 months after one procedure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
catheter ablation procedure
What this could lead to
If successful, this tailored approach could improve freedom from atrial fibrillation after a single procedure, reducing the need for repeat treatments.
What could go wrong
This is a completed study, but results may not apply to all patients. The tailored strategy is more complex and may carry higher risks like heart tissue damage or bleeding.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ascension St. Vincent's
Jacksonville, Florida, 32204, United States
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CHRU Nancy
Vandœuvre-lès-Nancy, 54511, France
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Centre Cardiologique du Nord
Saint-Denis, 93200, France
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Clinique Pasteur
Toulouse, 31076, France
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Clinique Rhéna
Strasbourg, 67000, France
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Clinique Saint George
Nice, 06105, France
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Deutsches Herzzentrum München
München, 80636, Germany
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Grandview Medical Center
Birmingham, Alabama, 35243, United States
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Hôpital Louis Pradel - Hospices Civils de Lyon
Lyon, 69677, France
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Hôpital Privé Jacques Cartier
Massy, 91300, France
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Hôpital Privé du Confluent
Nantes, 44200, France
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Hôpital Saint Philibert
Lomme, 59462, France
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Hôpital Saint-Joseph
Marseille, 13008, France
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Inova Fairfax
Falls Church, Virginia, 22042, United States
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Isala Hartcentrum Zwolle
Zwolle, 8025, Netherlands
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Klinikum Coburg
Coburg, 96450, Germany
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New York Presbyterian Queens Hospital
Queens, New York, 11355, United States
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Northwell Health
New York, New York, 10075, United States
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OLV Aalst
Aalst, 9300, Belgium
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OLVG Amsterdam
Amsterdam, 1091, Netherlands
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Ohio State University
Columbus, Ohio, 43210, United States
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Pôle Santé République
Clermont-Ferrand, 63000, France
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Rhode Island Hospital
Providence, Rhode Island, 02903, United States
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Städtisches Klinikum Karlsruhe
Karlsruhe, 76133, Germany
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UZ Leuven
Leuven, 3000, Belgium
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Washington University
St Louis, Missouri, 63130, United States