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Personalized heart ablation may beat standard procedure for AFib

NCT ID NCT04702451

Completed Disease control Sponsor: Volta Medical Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether a tailored ablation approach, which targets specific abnormal areas in the heart, works better than the standard anatomical ablation for people with persistent atrial fibrillation (AFib). 377 adults with AFib that didn't respond to medication were included. The tailored method uses a special mapping system to find and burn problem spots, while the standard method only isolates the pulmonary veins. The main goal was to see who stayed free of AFib for 12 months after one procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
catheter ablation procedure
What this could lead to
If successful, this tailored approach could improve freedom from atrial fibrillation after a single procedure, reducing the need for repeat treatments.
What could go wrong
This is a completed study, but results may not apply to all patients. The tailored strategy is more complex and may carry higher risks like heart tissue damage or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION

Contacts and locations

Locations

  • Ascension St. Vincent's

    Jacksonville, Florida, 32204, United States

  • CHRU Nancy

    Vandœuvre-lès-Nancy, 54511, France

  • Centre Cardiologique du Nord

    Saint-Denis, 93200, France

  • Clinique Pasteur

    Toulouse, 31076, France

  • Clinique Rhéna

    Strasbourg, 67000, France

  • Clinique Saint George

    Nice, 06105, France

  • Deutsches Herzzentrum München

    München, 80636, Germany

  • Grandview Medical Center

    Birmingham, Alabama, 35243, United States

  • Hôpital Louis Pradel - Hospices Civils de Lyon

    Lyon, 69677, France

  • Hôpital Privé Jacques Cartier

    Massy, 91300, France

  • Hôpital Privé du Confluent

    Nantes, 44200, France

  • Hôpital Saint Philibert

    Lomme, 59462, France

  • Hôpital Saint-Joseph

    Marseille, 13008, France

  • Inova Fairfax

    Falls Church, Virginia, 22042, United States

  • Isala Hartcentrum Zwolle

    Zwolle, 8025, Netherlands

  • Klinikum Coburg

    Coburg, 96450, Germany

  • New York Presbyterian Queens Hospital

    Queens, New York, 11355, United States

  • Northwell Health

    New York, New York, 10075, United States

  • OLV Aalst

    Aalst, 9300, Belgium

  • OLVG Amsterdam

    Amsterdam, 1091, Netherlands

  • Ohio State University

    Columbus, Ohio, 43210, United States

  • Pôle Santé République

    Clermont-Ferrand, 63000, France

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Städtisches Klinikum Karlsruhe

    Karlsruhe, 76133, Germany

  • UZ Leuven

    Leuven, 3000, Belgium

  • Washington University

    St Louis, Missouri, 63130, United States

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