Heart burn: can zapping heart tissue stop deadly rhythms in brugada syndrome?
NCT ID NCT05685134
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a procedure called radiofrequency catheter ablation in 20 people with Brugada syndrome, a heart condition that can cause dangerous heart rhythms. Half received the real ablation, which uses heat to destroy small areas of heart tissue thought to cause the problem, while the other half received a sham procedure. The goal was to see if the ablation could normalize the heart's electrical pattern and prevent life-threatening arrhythmias over one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiofrequency catheter ablation
- What this could lead to
- If successful, this procedure could reduce the risk of dangerous heart rhythms and potentially decrease the need for an implantable defibrillator in Brugada syndrome patients.
- What could go wrong
- This is a very small, early-stage trial with only 20 participants. The procedure involves burning heart tissue and carries risks like bleeding, infection, or heart damage. Results may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Instituto do Coração - InCor - HC/FMUSP
São Paulo, São Paulo, 05403-000, Brazil
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