New heart zapping device shows promise for stubborn AFib
NCT ID NCT05443594
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested the FARAPULSE system, a device that uses short electrical pulses to destroy small areas of heart tissue causing abnormal rhythms in people with persistent atrial fibrillation (AFib). The trial enrolled 669 adults with drug-resistant, symptomatic persistent AFib. Researchers measured safety and effectiveness over one year, tracking complications like stroke, heart damage, and blood clots.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
FARAPULSE Pulsed Field Ablation System (a device that uses electrical pulses to destroy heart tissue causing abnormal rhythms)
What this could lead to
If successful, this could offer a new, safer way to treat persistent atrial fibrillation without long-term medication.
What could go wrong
This is a single-arm study without a comparison group, so results may be less reliable. Risks include serious complications like stroke, heart damage, or blood clots.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Arrhythmia Research Group-Research Facility
Jonesboro, Arkansas, 72401, United States
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Banner University Medical Center Phoenix-Hospital
Phoenix, Arizona, 85006, United States
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Baptist Health Lexington
Lexington, Kentucky, 40503, United States
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Bethesda North Hospital-Hospital
Cincinnati, Ohio, 45242, United States
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Brigham and Women's Hospital-Hospital
Boston, Massachusetts, 02115, United States
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Catholic Medical Center-Hospital
Manchester, New Hampshire, 03102, United States
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Cedars - Sinai Medical Center-Hospital
Los Angeles, California, 90048, United States
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Christus Trinity Mother Frances Health System-Hospital
Tyler, Texas, 75701, United States
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Cleveland Clinic Foundation-Hospital
Cleveland, Ohio, 44195, United States
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Clinica Universidad de Navarra-Hospital
Pamplona, 31008, Spain
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Doylestown Hospital-Hospital
Doylestown, Pennsylvania, 18901, United States
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Emory University Hospital-Hospital
Atlanta, Georgia, 30322, United States
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Grandview Medical Center-Hospital
Birmingham, Alabama, 35243, United States
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Hospital of the University of Pennsylvania-Hospital
Philadelphia, Pennsylvania, 19104, United States
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Institut universitaire de Cardiologie et de Pneumologie de Quebec-Hospital
Ste-Foy, Quebec, G1V 4G5, Canada
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Johns Hopkins Hospital - East Baltimore Campus
Baltimore, Maryland, 21287, United States
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Lahey Clinic Hospital-Hospital
Burlington, Massachusetts, 01805, United States
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Lenox Hill Hospital
New York, New York, 10075, United States
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Massachusetts General Hospital-Hospital
Boston, Massachusetts, 02114, United States
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McGill University Health Centre-Hospital
Montreal, Quebec, H3G 1A4, Canada
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Mercy Hospital Medical Center-Hospital
West Des Moines, Iowa, 50266, United States
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Mount Sinai Medical Center-Hospital
New York, New York, 10029, United States
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NYU Langone Health Heart Rhythm Center
New York, New York, 10016, United States
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Northwestern University-Hospital
Evanston, Illinois, 60208, United States
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OhioHealth Research and Innovation Institute - Riverside Methodist Hospital-Hospital
Columbus, Ohio, 43214, United States
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Orion Medical - Gulf Commerce Drive
Houston, Texas, 77034, United States
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Scripps Memorial Hospital-Hospital
La Jolla, California, 92037, United States
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Sentara Norfolk General Hospital-Hospital
Norfolk, Virginia, 23507, United States
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St. Francis Hospital-Hospital
Roslyn, New York, 11576, United States
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St. John's Hospital-Hospital
Springfield, Illinois, 62769, United States
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St. Luke's Hospital of Kansas City-Hospital
Kansas City, Missouri, 64111, United States
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St. Lukes Idaho Cardiology Associates-Hospital
Boise, Idaho, 83712, United States
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St. Thomas Research Institute, LLC-Hospital
Nashville, Tennessee, 37205, United States
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St. Vincent's Hospital-Hospital
Indianapolis, Indiana, 46260, United States
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Texas Cardiac Arrhythmia Research-Hospital
Austin, Texas, 78705, United States
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Trident Medical Center-Hospital
Charleston, South Carolina, 29406, United States
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UPMC Heart and Vascular Institute Harrisburg
Harrisburg, Pennsylvania, 17101, United States
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UZ Brussel (AZ VUB)-Hospital
Brussels, 1090, Belgium
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University of California, San Francisco-Hospital
San Francisco, California, 94143-0112, United States
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University of Kansas Hospital-Hospital
Kansas City, Kansas, 66160, United States
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Valley Hospital-Hospital
Ridgewood, New Jersey, 07450, United States
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Vanderbilt University Medical Center-Hospital
Nashville, Tennessee, 37232, United States
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Virginia Commonwealth University Health System-Hospital
Richmond, Virginia, 23219, United States
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Weill Cornell Medical University-Hospital
New York, New York, 10021, United States