Could a simple hormone boost improve IVF success?

NCT ID NCT04806919

Completed Disease control Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving a higher dose of vaginal progesterone (800 mg vs 1200 mg daily) can improve pregnancy rates in women with low progesterone levels on the day of embryo transfer. It involved 87 women undergoing a single frozen embryo transfer. The goal was to see if the higher dose leads to more ongoing pregnancies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: micronized progesterone (Amelgen)
What this could lead to: If successful, this could show that a higher progesterone dose helps more women achieve ongoing pregnancy after embryo transfer.
What could go wrong: This is a small, completed Phase 3 trial with only 87 participants, so results may not apply to all IVF patients. Increasing dose may not improve outcomes and could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Embryo Loss ventricular fibrillation, paroxysmal familial, type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMBRYO LOSS IVF LUTEAL PHASE DEFECT

Contacts and locations

Locations

AZ Delta

Roeselare, Belgium
UZ Ghent

Ghent, 9000, Belgium

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