Atrial fibrillation

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study tests whether combining two procedures—closing the left atrial appendage and using pulsed field ablation to correct heart rhythm—works better than closing the appendage alone in people with persistent atrial fibrillation and high stroke risk. Fifty participants will be…

This study tests whether a procedure called pulsed field ablation (PFA) is safer and more effective than anti-arrhythmic drugs as a first treatment for people with persistent atrial fibrillation, a type of irregular heartbeat. About 484 participants will be randomly assigned to r…

This study looks at how safe and effective a new treatment called FARAPULSE pulsed field ablation is for people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 228 participants will be followed for up to 12 months to see if the procedure stops the …

This study tests a wrist-worn device called CardiaCare RR2 that stimulates the median nerve to calm irregular heart rhythms after catheter ablation for atrial fibrillation (AF). About 34 adults who have had AF ablation will use the device daily for six months. Half will receive a…

This study is tracking over 1,100 people with atrial fibrillation who are treated with the FARAPULSE system, a device that uses electrical pulses to destroy tiny areas of heart tissue causing the irregular rhythm. The goal is to see how well it works and how safe it is in everyda…

This registry tracks 550 people with atrial fibrillation who are treated with the FARAPULSE pulsed field ablation system, using a special catheter and mapping technology. The goal is to see how safe and effective the procedure is in real-world settings over one year. Researchers …

This study follows 200 adults with persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year) who are treated with the Sphere-9 catheter and Affera ablation system. The goal is to see how safe the procedure is and how well it prev…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study tests whether a personalized catheter ablation approach, guided by mapping low-voltage areas in the heart, works better than standard ablation for people with persistent atrial fibrillation (AFib). About 510 adults with persistent AFib will be randomly assigned to rece…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study looks at how well a special catheter (THERMOCOOL SMARTTOUCH SF) and software (Ablation Index) work to treat paroxysmal atrial fibrillation, a type of irregular heartbeat. Researchers will track 150 adults who get this procedure to see if they stay free of heart rhythm …

This study compares a new oral blood thinner, milvexian, to the standard apixaban in about 20,000 adults with atrial fibrillation (an irregular heartbeat). The goal is to see if milvexian is at least as good at preventing strokes and blood clots, while also checking for major ble…

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Par…

This early study tests a device that closes a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation who cannot take blood thinners. The goal is to lower the risk of stroke without needing lifelong medication. About 58 participants will be followe…

This study tests a device called Amulet 2 that is implanted in the heart to seal off a small pouch (the left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. About 4…

This study tests whether adding a nerve-calming kidney procedure (renal denervation) to standard heart ablation (pulsed-field ablation) can better prevent atrial fibrillation from coming back. About 86 adults with persistent AFib will be randomly assigned to get either the combin…

This study is tracking 100 adults who receive an EluPro antibiotic-eluting envelope during implantation of a heart device (like a pacemaker). The envelope slowly releases antibiotics to prevent infection. Researchers are monitoring complication rates in real-world use to see how …

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study looks at a procedure called cryoablation that uses a freezing balloon to destroy tiny areas of heart tissue causing an irregular heartbeat (persistent atrial fibrillation). About 400 adults with this condition will be followed for up to 3 years to see how well the trea…

This study looks at whether doing a heart procedure called cryoablation right away in the emergency room can help people with recent atrial fibrillation (AFib). About 350 adults with AFib that started within the past year will be randomly assigned to get either immediate ablation…

This registry is following 10,000 people with atrial fibrillation who are getting a procedure called pulsed field ablation using the Farapulse system. The goal is to see how well it stops irregular heart rhythms and how safe it is in everyday medical practice. Researchers will tr…

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This study looks at whether measuring blood pressure inside the heart's left upper chamber during a procedure for atrial fibrillation (an irregular heartbeat) can spot patients with hidden heart failure. If the pressure is high, patients get a heart failure checkup and medication…

This study tests a new device that uses special electrical pulses to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. About 150 adults aged 18-75 who have not responded well to medication will receive the treatment. The goal is to see if the de…

This early study tests a new device called the FieldForce Ablation System in 35 people with atrial fibrillation (AFib). The device uses short electrical pulses to destroy tiny areas of heart tissue causing the irregular rhythm. The main goals are to see if it is safe and if it ca…

This study tests a technique called acute normovolemic hemodilution (ANH) in 2000 high-risk heart surgery patients. Before the heart-lung machine is used, doctors remove some blood and replace it with fluids. The goal is to see if this reduces the number of patients who need a bl…

This study compares three catheter ablation techniques for people with persistent atrial fibrillation (AF), a heart rhythm disorder. About 617 adults having their first ablation will be randomly assigned to one of three groups: isolating the pulmonary veins alone, adding ablation…

This pilot study tests whether using advanced imaging (ECGI, MRI, and PET scans) to identify abnormal heart tissue and electrical circuits can improve catheter ablation for persistent atrial fibrillation. Fifty-two adults with persistent AF who have not had prior ablation will re…

This study tests a new device system that uses pulsed electric fields to treat atrial fibrillation, a common heart rhythm problem. About 300 people with symptomatic, recurrent atrial fibrillation will receive the procedure. The goal is to see if it safely and effectively restores…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study compares two catheter ablation techniques for atrial fibrillation (AF), a condition where the heart beats irregularly. One method uses a standard approach with a drug called adenosine to find missed spots, while the other adds an extra ring of ablation without the drug…

This study tests whether adding the weight-loss drug liraglutide and a lifestyle program to standard catheter ablation can reduce fat around the heart and improve outcomes for people with atrial fibrillation (AF). About 60 adults with AF and a BMI of 27 or higher will take liragl…

This study follows 2000 people who have or will get the OmniaSecure defibrillation lead, a wire that helps control dangerous heart rhythms. Researchers will track how often the lead causes problems over 5 years. The goal is to make sure the lead is safe and works as expected in e…

This study tests whether a newer pacing method (conduction system pacing) is as good as or better than standard biventricular pacing in heart failure patients with atrial fibrillation who need a heart ablation. About 82 participants will be randomly assigned to one of the two pac…

This study looks at two ways to treat a type of irregular heartbeat called non-paroxysmal atrial fibrillation (AFib) that doesn't go away on its own. Both methods use a new technique called pulsed-field ablation to destroy tiny areas of heart tissue causing the problem. One group…

This study looks at a procedure called hybrid convergent ablation for people with a long-lasting type of irregular heartbeat (atrial fibrillation) that hasn't improved with medication. The procedure uses heat energy to destroy heart tissue causing the problem, combining a small c…

This study tests a device called the Farapulse system, which uses electrical pulses to treat atrial fibrillation (AFib), a common heart rhythm problem. Researchers will enroll 275 adults with AFib who are already scheduled for a catheter ablation procedure. The goal is to see if …

This study compares three different surgical ablation techniques (Cox-Maze IV, Tampa 2, and EnCompass alone) to treat atrial fibrillation, a common heart rhythm problem. About 220 adults with AFib who are already having heart surgery will be randomly assigned to one of the three …

This study tests whether a tailored exercise and education program, given before and after a first-time atrial fibrillation ablation, can improve heart fitness and quality of life compared to standard care. About 107 adults scheduled for ablation will be randomly assigned to eith…

This study tests a new, less invasive surgical approach for people with persistent atrial fibrillation (AFib), a heart rhythm problem that can be hard to treat. The procedure combines two techniques: ablation (creating tiny scars to block faulty signals) and closing off the left …

This study tests whether a new drug called Refralon, taken as a tablet once or twice daily, can prevent atrial fibrillation or flutter from returning after normal heart rhythm has been restored. About 175 adults with persistent AFib will receive either Refralon or a placebo for 6…

This study tests a catheter ablation procedure for people with persistent or long-standing persistent atrial fibrillation, a type of irregular heartbeat that is hard to treat. The procedure uses electroporation and radiofrequency energy to create scars in the heart that block abn…

This study tests whether a computer alert in doctors' charts can help more atrial fibrillation patients get blood thinners to prevent strokes. About 5,094 patients and their doctors are involved. The alert fires during visits if a patient has high stroke risk but isn't on blood t…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study compares two approaches—short-term anticoagulation (stronger blood thinners) versus antiplatelet therapy (milder blood thinners)—to prevent clots on a device placed in the heart's left atrial appendage. The trial involves 510 adults who have had this procedure. The goa…

This study tests whether adding extra ablation to the back wall of the heart's left atrium improves outcomes for people with persistent atrial fibrillation (a type of irregular heartbeat). About 206 participants will receive either standard vein isolation or vein isolation plus b…

This study compares two ways to treat a heart condition called atrial fibrillation (AFib) that causes an irregular heartbeat. The standard method uses freezing (cryoballoon), while the newer method uses electrical pulses (pulsed field ablation). The goal is to see if the new meth…

This study tests whether measuring amiodarone levels in the blood helps doctors choose the right dose for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). About 80 adults will receive different daily doses (100, 200, or 400 mg) and be monitored for thre…

This study compares two ways to repeat a heart ablation for people with persistent atrial fibrillation (AF) whose first ablation didn't work. The standard repeat method isolates the pulmonary veins; the experimental method also treats the left atrial posterior wall. Researchers w…

This study tests whether an implantable heart monitor with remote follow-up can help doctors decide when to prescribe blood thinners to patients who have had a heart attack and developed new atrial fibrillation. The goal is to reduce bleeding complications compared to the standar…

This study tests two different ablation techniques using a new, safer method called pulsed-field ablation (PFA) in 300 adults with persistent atrial fibrillation (a type of irregular heartbeat). One group gets standard vein isolation, while the other gets additional targeted burn…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This study is testing a new device called CLAAS that is implanted in the heart to close off a small pouch (the left atrial appendage) where blood clots often form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners…

This study tests whether intensive lifestyle changes—like treating sleep apnea, cutting alcohol, exercising, losing weight, and managing blood pressure—can stop atrial fibrillation (AF) from coming back after a heart procedure called catheter ablation. About 509 people with AF wh…

This study compares two types of ablation—pulse field and radiofrequency—for treating persistent atrial fibrillation, a common heart rhythm problem. Fifty participants will receive one of the two procedures to isolate faulty electrical areas in the heart. The goal is to see which…

This study tests a new device called the Conformal Left Atrial Appendage Seal in 64 adults with non-valvular atrial fibrillation who are at high risk for stroke. The device is placed to close off a small pouch in the heart where blood clots can form, offering an alternative to lo…

This study tests if a device that closes a small pouch in the heart (left atrial appendage) is safer and more effective than long-term blood thinners for preventing strokes in people with atrial fibrillation. About 2,650 participants with AFib and high stroke risk are randomly as…

This pilot study tests whether drinking tart cherry concentrate for three days before heart valve surgery can reduce the risk of post-operative atrial fibrillation (an irregular heartbeat). The study involves 50 adults aged 50-79 who are in normal heart rhythm before surgery. Res…

This study compares two ways of doing a heart procedure called catheter ablation for people with atrial fibrillation (an irregular heartbeat). One method uses X-rays to guide the doctor, and the other does not. The goal is to see if the no-X-ray method works just as well and is a…

This study tests a new device called the Globe Pulsed Field System to treat people with atrial fibrillation (AF), a common heart rhythm problem. The device uses electrical pulses to destroy small areas of heart tissue causing the irregular rhythm. About 549 participants will be f…

This pilot study was designed to test a new, more targeted way to perform ablation for atrial fibrillation (AFib). Instead of burning a wide area around the pulmonary veins, doctors would use special mapping technology to precisely target the heart muscle sleeves causing the abno…

This study looks at whether using a CPAP machine at night can reduce the chance of atrial fibrillation (an irregular heartbeat) returning in people who have both sleep apnea and a history of AF. Researchers will follow 91 adults for 12 months, tracking how often they use CPAP and…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study tests a new balloon catheter that uses pulsed electric fields instead of heat to treat atrial fibrillation (AFib), a common heart rhythm problem. About 35 adults with short-lasting AFib will receive the procedure. The goal is to see if the balloon safely and effectivel…

This early study tests a new balloon-shaped catheter that uses pulsed electric fields to treat persistent atrial fibrillation, a type of irregular heartbeat. Thirty-four adults aged 18 to 75 with the condition will receive the procedure. Researchers will check safety within 7 day…

This study compares dabigatran (Pradaxa) to warfarin for preventing strokes in 370 people with both atrial fibrillation and moderate-to-severe mitral stenosis. Participants are randomly assigned to one of the two blood thinners. The goal is to see if dabigatran is as good as or b…

This study tests whether adding ablation of scarred heart tissue to standard pulmonary vein isolation helps people with persistent atrial fibrillation stay free of irregular heartbeats. Two hundred participants will be randomly assigned to one of two ablation procedures. The main…

This pilot study tests a new device that uses special electrical pulses (coherent sine-burst electroporation) to treat atrial fibrillation, a common heart rhythm problem. The device aims to isolate the pulmonary veins, which are often the source of the abnormal signals. The study…

This study tests a modified Maze procedure done during heart surgery to treat atrial fibrillation, a common heart rhythm problem. About 151 adults with AFib scheduled for heart surgery will receive the procedure, which uses heat or cold to create scar lines in the heart and close…

This study is testing a device called the Omega™ LAA Occluder in 200 people with non-valvular atrial fibrillation who are at high risk for bleeding. The device is implanted to seal off the left atrial appendage, a small pouch in the heart where clots often form. The goal is to re…

This study tests a single 30-minute IV infusion of HBI 3000 in 150 adults with atrial fibrillation that started within the last 3 days. The goal is to safely convert the heart back to normal rhythm. The trial first finds the best dose, then compares it to a placebo in a blinded f…

This study tests whether using a patient's gender, weight, and kidney function to calculate the starting dose of the blood thinner heparin gets patients to the right level faster than the standard flat rate. About 145 adults with blood clots, atrial fibrillation, or mechanical he…

This study follows 200 people with persistent atrial fibrillation (AF) who undergo a heart procedure using Abbott's ablation catheter. The catheter uses heat to scar tiny areas in the heart and block faulty electrical signals. Researchers track how many patients stay free of AF f…

This phase 2 study compares abelacimab, a new biologic blood thinner, to the standard drug rivaroxaban in 1,287 people with atrial fibrillation who are at moderate-to-high risk of stroke. The goal is to see if abelacimab causes fewer major or clinically relevant bleeding events w…

This study was designed to test a device called LAmbre Plus, which is implanted to seal off a small pouch in the heart where clots can form in people with atrial fibrillation. The goal was to see if it could safely prevent strokes in patients with large or irregularly shaped hear…

This study tracks 344 adults with paroxysmal atrial fibrillation (a type of irregular heartbeat) who are having their first catheter ablation procedure using a specific device. The goal is to see how well the procedure works and how safe it is in everyday medical practice. Resear…

This study tests whether using an implantable heart monitor (or a wearable patch) to detect atrial fibrillation early after catheter ablation can reduce the total time spent in AF. About 120 people with paroxysmal or persistent AF will be monitored for 15 months. The goal is to s…

This study observes over 600 people with atrial fibrillation who received the Amulet device to close a part of the heart called the left atrial appendage. The goal is to see how well the device prevents strokes and bleeding in everyday medical practice. Participants are followed …

This study tests two ways to do a catheter ablation for a type of fast heartbeat called atrial tachycardia that comes from heart scar tissue. One method uses a new mapping system (Ripple Mapping) to guide the ablation, while the other uses the standard approach. The goal is to se…

This study compares two procedures for people aged 75 and older with persistent atrial fibrillation (an irregular heartbeat). One group gets a pacemaker plus ablation of the heart's electrical node, while the other gets pulmonary vein isolation using cryoenergy. The goal is to se…

This study tests whether having extra appointments with a heart specialist at a local GP practice helps people get better treatment for heart, kidney, metabolic, and lung conditions. 138 high-risk adults will either receive standard GP care or additional specialist reviews to opt…

This trial tests a new device called the Synaptic Cryoablation System, which uses a balloon to freeze small areas of the heart and correct irregular heartbeats in people with paroxysmal atrial fibrillation. 128 participants will receive the treatment and be followed for 12 months…

This study tests whether one-on-one education from a trained pharmacist can help people with atrial fibrillation take their blood thinners (DOACs) as prescribed. About 400 patients will either receive this extra support or usual care. The goal is to see if the education improves …

This study compares three catheter ablation strategies in 300 adults with persistent atrial fibrillation and heart failure. The goal is to see which approach best reduces the risk of death, hospitalization, or urgent visits due to worsening heart failure. Participants are randoml…

This study tests whether using a personalized risk score (ABC-score) to guide treatment can lower the chance of stroke or death in people with atrial fibrillation, a common heart rhythm problem. About 3,900 participants are randomly assigned to either standard care or treatment b…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study is testing whether a special home blood pressure monitor that can detect atrial fibrillation (AFib) helps diagnose the condition faster in older adults with high blood pressure. About 1,900 participants aged 60 and older will take daily blood pressure readings and answ…

This study tests whether smartwatches can detect atrial fibrillation (AF) in people who recently had a stroke. Participants already have an implanted heart monitor (the gold standard) and will also wear a smartwatch for 12 weeks. The goal is to see how well the smartwatch catches…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study tests a new MRI contrast agent called Gadopiclenol to see if it provides clearer images of heart damage in people with atrial fibrillation (AF). Researchers will compare it to standard contrast agents in 50 AF patients. The goal is to improve diagnosis and guide treatm…

This study tests whether an artificial intelligence program can use a simple, single-lead handheld ECG device to find people with undiagnosed atrial fibrillation (AF), a common heart rhythm problem. About 200 adults aged 50-90 will use a device at home and complete surveys. The g…

This study is testing whether monthly 12-lead ECG screenings at family health centers can detect undiagnosed atrial fibrillation (AF) in adults aged 65 and older. Participants will have 12 monthly visits over a year, and if AF is found, they will be started on blood thinners to r…

This study was designed to test a new portable ECG recorder called Hativ P30, which uses artificial intelligence to analyze heart rhythms. Researchers planned to compare its readings to a standard 12-lead ECG in adults, including those with and without arrhythmias. However, the s…

This study is testing whether a smart blood pressure cuff called the Withings BPM Core can accurately detect atrial fibrillation, a common heart rhythm problem. Researchers will compare the device's single-lead ECG readings to a standard 12-lead ECG in 160 adults. If it works wel…

This study checks how well the Withings Move ECG watch can detect atrial fibrillation (an irregular heartbeat) compared to a standard 12-lead ECG. About 234 adults will wear the watch and get a standard ECG to see if the watch's automatic reading is accurate. The goal is to see i…

This study is testing whether a wearable heart monitor (Zio patch) worn for two weeks can detect undiagnosed atrial fibrillation in women aged 70 and older. Atrial fibrillation is a common heart rhythm problem that raises stroke risk, especially in older women. The goal is to see…

This study tests whether an Apple Watch, worn over a long period, can catch early signs of atrial fibrillation (a type of irregular heartbeat) in people who are at high risk but haven't been diagnosed yet. About 2,000 participants who had a previous ECG and a high AI risk score w…

This study tests whether smartphone sensors and AI can accurately detect atrial fibrillation (AF), a common heart rhythm disorder. Researchers will collect heart sounds, one-lead ECGs, and facial blood flow data from 209 adults with and without AF. The goal is to see if these sma…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This study is testing whether a new risk score can help find people who have atrial fibrillation (an irregular heartbeat) but don't know it yet. About 1,955 adults at higher risk will use a remote ECG monitor at home. The goal is to see if the risk score correctly identifies who …

This study tests whether adding N-Acetylcysteine (NAC) to the standard drug amiodarone can better prevent atrial fibrillation (a type of irregular heartbeat) in people at high risk after major chest surgery. About 184 adults having lung or esophagus surgery will be randomly assig…

This study tests whether closing the left atrial appendage—a small sac in the heart where blood clots often form—during planned heart surgery can prevent strokes in people with atrial fibrillation. About 1500 patients having coronary bypass or valve surgery are included. The goal…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the risk of developing atrial fibrillation (an irregular heartbeat) in healthy adults. Over 25,000 men and women without prior heart disease or stroke took part. Researchers are tracking who deve…

This study tests whether the diabetes drug metformin, combined with lifestyle changes like diet and exercise, can reduce episodes of atrial fibrillation (an irregular heartbeat) in people with pacemakers or defibrillators. About 175 participants will take metformin or a placebo a…

This study tests a simpler deep-sedation method for people having a heart procedure called pulsed-field ablation to treat atrial fibrillation (an irregular heartbeat). The goal is to see if the new sedation approach is safe and makes patients more comfortable. About 40 adults wil…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study tests a simple, non-invasive device that gently stimulates a nerve in the ear (tVNS) to see if it can improve cognitive function in people over 60 with atrial fibrillation. For 6 months, 60 participants will use the device daily after exercise. Researchers will measure…

This study tests whether adding blood flow restriction (BFR) to standard resistance training helps heart rehab patients get stronger and healthier. Twenty adults with stable heart disease will do exercises with and without a special cuff that limits blood flow to the arms and leg…

This study tests whether adding group weight-loss classes to standard cardiac rehabilitation helps people with atrial fibrillation and obesity lose at least 10% of their body weight. About 120 adults will take part, with half getting the extra classes. The goal is to see if this …

This study tests whether a nerve block given before heart surgery can reduce pain and the need for opioid painkillers afterward. About 150 adults having heart surgery will receive either a long-acting or standard form of the numbing drug bupivacaine via ultrasound-guided injectio…

This study tests a short program that helps heart patients and their families explore what gives life meaning during cardiac rehab. About 80 people in Denmark will try one of three formats: one-on-one, with a relative, or in a group. The goal is to see if this approach can reduce…

This study tests whether a sticky disc called StatSeal helps people recover faster after a common heart procedure for atrial fibrillation. After the procedure, doctors must close the blood vessel in the leg to stop bleeding. Currently, they often use a stitch (figure-of-eight). T…

This study compares a common heart procedure called pulmonary vein isolation (PVI) to a fake (sham) version to see if it truly reduces symptoms of atrial fibrillation. About 262 people with symptomatic AF will be randomly assigned to receive either the real procedure or a sham pr…

This study looks at a new way to analyze electrical signals in the heart to help doctors find exactly where to burn during atrial fibrillation treatment. Researchers will review data from 336 patients who had the procedure, comparing those who stayed free of AFib for a year with …

This study compares six different ECG patches that people wear for a week to monitor heart rhythms. Researchers want to see which patches give the clearest and most useful recordings. The study involves 150 adults aged 65 and older who already need heart monitoring as part of the…

This registry is collecting data from over 500 patients with atrial fibrillation who are treated with the FARAPULSE ablation system in routine care. The goal is to identify which pre-procedure, procedure, and follow-up steps work best for different types of patients. Researchers …

This study tests whether a special CT scan (CCTA) of the heart can predict if atrial fibrillation will come back after a standard ablation procedure. Researchers will scan patients before their first ablation and then follow them for a year. The goal is to see if heart structure …

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study looks at people with persistent atrial fibrillation (an irregular heartbeat) and moderate-to-severe functional mitral regurgitation (a leaky heart valve). Researchers want to see if a procedure called catheter ablation—which zaps abnormal heart tissue to restore normal…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This registry follows 545 people with arrhythmia who received a heart ablation using the DiamondTemp system. Researchers will track how many stay free of their heart rhythm problem and how many have serious side effects over 12 months. The goal is to see how well the device works…

This pilot study looks at whether a simple, non-invasive eye scan (OCT-A) can detect early signs of memory decline in people with atrial fibrillation, a common heart rhythm disorder. Researchers will compare retinal blood vessel patterns in 40 patients with and without mild cogni…

Over two million people in the UK have a chronic condition like diabetes or heart disease without knowing it. This study will use information from 4.5 million hospital patients to build a digital platform that spots those at risk. The goal is to help doctors diagnose these condit…

This study follows 100 ICU patients who developed new atrial fibrillation (AF) during their stay. Using a chest-worn heart monitor, researchers track whether AF returns after leaving the ICU and up to 3 months after hospital discharge. The goal is to understand who might need lon…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study looks at whether a new computer algorithm can predict if atrial fibrillation (an irregular heartbeat) will come back after a common treatment called pulmonary vein isolation. Researchers will review medical records from 300 patients who had this procedure. The goal is …

This study looks at two methods for treating atrial fibrillation (an irregular heartbeat) using a special balloon catheter. The goal is to see if using a 3D mapping system (CARTO) makes the procedure faster and safer than using X-ray guidance alone. About 60 adults with paroxysma…

This study aimed to validate several blood biomarkers (like NT-proBNP and IL-6) to help doctors assess atrial fibrillation burden and track treatment effectiveness. Researchers planned to analyze samples from 266 patients before and after treatment. However, the study was withdra…

This study watches 40 adults who need a leadless pacemaker to see if where the device sits inside the heart changes heart rhythm or pumping strength. Researchers will use CT scans and ECGs to check heart function and valve leakage. The goal is to find the best spot for the pacema…

This study is a registry that collects information and blood samples from over 2,400 people with atrial fibrillation who are scheduled for a heart procedure called ablation. The goal is to learn which patients benefit most from the procedure and to better understand what causes a…

This study checks if insulin resistance (when your body doesn't use insulin well) can predict whether a heart procedure called pulsed field ablation will work for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their first ablation…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study is a large registry that collects medical data and tissue samples from 30,000 people with heart disease and healthy volunteers. Researchers will analyze this information to better understand risk factors, treatments, and outcomes for various heart conditions. The goal …

This study tests whether watching storytelling videos can help African American and Black patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners to prevent strokes. About 80 adults who are not currently on blood thinners but have a hig…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study tests whether a small device placed under the skin can detect hidden atrial fibrillation (an irregular heartbeat) in people with heart failure who are at high risk for stroke. About 477 participants either received the implant or standard care. The goal is to see if th…

This study watches 50 people with chronic lymphocytic leukemia (CLL) who are starting a type of drug called a BTK inhibitor. These drugs can cause high blood pressure and irregular heartbeats. Participants will use a wearable device at home to track their heart rhythm and blood p…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study observes 1,000 adults aged 65 and older with atrial fibrillation who take blood thinners. Researchers will check if the doses match official guidelines and how consistently patients take their medication. The goal is to identify unsafe practices and refer patients to h…

This study looks at heart rhythm problems in people with hypertrophic cardiomyopathy, a condition where the heart muscle is thicker than normal. Researchers want to see how often new rhythm issues like atrial fibrillation happen, and whether sleep apnea plays a role. About 260 ad…

This study follows 5,000 adults in Southwest China with persistent atrial fibrillation (a type of irregular heartbeat) for up to 5 years. Researchers will collect information on patients' health, treatments, and outcomes to learn which approaches work best and why. The goal is to…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study looks at two methods of giving the blood thinner heparin during a procedure called atrial fibrillation ablation. The goal is to see which method keeps the blood's clotting time in a safe range more often. Researchers reviewed records of 300 patients who had the procedu…

This study follows 186 adults with atrial fibrillation who are having a heart ablation procedure. Doctors use an AI software to guide the treatment, and researchers track how well it works and any side effects over two years. The goal is to see if the AI helps improve outcomes an…

This study looks at whether a special training program can help family doctors use focused heart ultrasound (FoCUS) to accurately detect common heart conditions like heart failure and valve disease. About 500 patients will get both a family doctor's FoCUS and a cardiologist's ful…

This study looks at whether a special type of ECG (called wavECG) can predict atrial fibrillation, a common irregular heartbeat after open-heart surgery. Researchers will follow 100 patients having their first heart surgery, using wavECG and echocardiograms to see who develops at…

This study looks at how safe and effective newer blood thinners (NOACs) are for Korean adults with atrial fibrillation, a heart rhythm problem that raises stroke risk. Researchers will track about 1,000 patients for strokes, bleeding, and heart events. The goal is to better under…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study tests whether sending cardiologists regular emails about quality goals helps them prescribe recommended medications for heart failure and atrial fibrillation. Researchers will track prescribing rates for 7,000 patients. The goal is to see if simple feedback can improve…

This study looks at whether actively cooling the esophagus during a common heart procedure (ablation for atrial fibrillation) helps improve outcomes and reduce side effects. Researchers will follow 312 adults with symptomatic atrial fibrillation who are already scheduled for abla…

This registry follows 75 pregnant women with heart disease to better understand the risks and outcomes for both mother and baby. Researchers will track health data for one year and check vital status at five years. The goal is to fill knowledge gaps and improve future care for th…

This study looks at whether people with atrial fibrillation (AF) have temporary drops in thinking skills during an AF episode. Researchers will test 600 patients using tablet-based games that measure memory, attention, and decision-making while in AF and again after their heart r…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study was designed to see if a new, ultra-sensitive mapping technique could better confirm that cryoballoon ablation successfully isolated the pulmonary veins in patients with paroxysmal atrial fibrillation. The trial was withdrawn before enrolling any participants, so no re…

This study looks at a possible side effect of a heart treatment called PFA for atrial fibrillation: injury to the phrenic nerve, which can paralyze part of the diaphragm and affect breathing. Patients get a special X-ray before and after the procedure to check diaphragm movement.…

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study follows 1,400 women who had a stroke with no known cause. Researchers use a small implantable heart monitor to check for hidden atrial fibrillation, an irregular heartbeat that can cause strokes. The goal is to see if detecting this condition and using blood thinners c…

This study uses a noninvasive 3D mapping system to look at the heart's electrical activity in 50 people with persistent atrial fibrillation (AF) lasting over 6 months. Researchers want to see how the heart changes after a standard ablation procedure and what factors might predict…

This study uses a wireless patch to monitor the heart rhythms of 1,200 patients at high risk for atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. Participants are adults over 50 with certain acute conditions like heart failure or sepsis, but no kno…

This study aims to uncover the genetic roots of atrial fibrillation, a common heart rhythm disorder. Researchers are collecting blood samples and health data from 1,300 adults—some with the condition and some without—to compare their DNA. The goal is to identify genetic variants …