Atrial fibrillation

This study looks at whether pulsed-field ablation (PFA), a non-thermal technique that uses electric pulses to target faulty heart tissue, can reverse structural changes in the heart caused by persistent atrial fibrillation (AF). Researchers will enroll 30 people with persistent A…

This study aimed to see if a short course of the heart medication amiodarone could prevent atrial fibrillation (an irregular heartbeat) in adults after heart surgery. About 1 in 3 patients experience this complication. However, the study was withdrawn before enrolling any partici…

This study tests whether using a wearable device (like a smartwatch) to monitor patients remotely can help doctors adjust heart failure medications more effectively. It includes 400 adults with both heart failure and atrial fibrillation. The goal is to improve treatment and reduc…

This study tests a 'nudge' program—including text reminders, a medication calendar, and an action plan—to help 84 adults with atrial fibrillation take their blood thinners consistently. Participants will watch an educational video, create a daily pill-taking routine, and receive …

This study tests a new technique called PWI-Box, which uses a device named GeminiS to isolate the pulmonary veins and treat atrial fibrillation (AF) during open-heart surgery. About 200 adults with AF who are already scheduled for heart surgery via sternotomy will take part. The …

This study compares two approaches to blood thinning after a heart attack in patients with atrial fibrillation. One group gets two blood thinners (a DOAC plus clopidogrel), while the other gets only one (a DOAC alone). The goal is to see if using just one drug reduces bleeding ri…

This study tests whether adding a preventive procedure called pulmonary vein isolation (PVI) to the standard ablation for typical atrial flutter can reduce the risk of heart-related hospital visits, stroke, or death. The trial enrolls adults aged 55 and older with an enlarged lef…

This registry will follow 500 people with symptomatic atrial fibrillation who are scheduled for a heart ablation using the Globe Pulsed Field System. The goal is to see how well the device controls the heart rhythm over 12 months and to track any major side effects within the fir…

This study compares a heart procedure called catheter ablation to standard medical treatment for people with atrial fibrillation (an irregular heartbeat) and heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). The …

This trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce the return of atrial fibrillation (AFib) after a heart procedure called catheter ablation. Overweight or obese adults with persistent AFib will receive either tirzepatide injections plus st…

This study tests a new device called the VERAFEYE System, which creates a 3D model of the heart to guide doctors during catheter ablation for paroxysmal atrial fibrillation (a type of irregular heartbeat). About 100 adults who are already scheduled for ablation will have the proc…

This study tests whether pacing the heart from a specific spot (posterosuperior bundle) can lower the chance of atrial fibrillation (AF) in people with sinus node dysfunction (a slow or irregular heartbeat). About 300 adults who need a pacemaker will be randomly assigned to get p…

This trial tests whether adding extra ablation lines to the standard pulsed-field ablation procedure helps people with long-standing atrial fibrillation (AF) stay in normal heart rhythm. 430 participants with AF lasting 1-3 years will be randomly assigned to receive either standa…

This study tests whether a non-invasive ear stimulation, called low-level tragus stimulation, can reduce inflammation and early heart rhythm problems after pulsed field ablation for atrial fibrillation. Forty-six adults with atrial fibrillation will receive either active or sham …

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study tests a catheter-based procedure called Varipulse to treat paroxysmal atrial fibrillation (irregular heartbeat that comes and goes). Researchers want to see how well it works long-term when combined with different types of sedation. About 300 adults aged 18-80 with sym…

This study will enroll 30,000 adults in China with atrial fibrillation (a type of irregular heartbeat) that hasn't improved with medication. They will receive a new type of catheter treatment called pulse-field ablation. Researchers will track their health for up to 10 years to s…

This study tests a procedure called pulsed field ablation (PFA) for people with early-stage atrial fibrillation (AFib) diagnosed within the last 3 years. The procedure uses a balloon to deliver energy that isolates the pulmonary veins, aiming to stop abnormal heart rhythms. Resea…

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study compares a stepwise blood-thinning approach to the standard method in 424 patients with atrial fibrillation who are at high risk for stroke and need a heart device like a pacemaker. The stepwise plan involves stopping the blood thinner one day before surgery and restar…

This study tests whether a newer drug, Vernakalant, works better than the standard Amiodarone for treating atrial fibrillation (irregular heartbeat) that often occurs after heart surgery. About 50 adults who recently had heart surgery will receive one of the two drugs. The main g…

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study compares two types of pacemaker procedures in adults with heart failure and atrial fibrillation who are not candidates for rhythm control. All participants will receive a heart ablation, then be randomly assigned to either conduction system pacing or standard cardiac r…

This study tests whether a new catheter ablation system using pulsed field energy can better control persistent atrial fibrillation (AF) by targeting low-voltage areas in the heart and isolating the superior vena cava, in addition to standard pulmonary vein isolation. About 618 a…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests a new way to treat atrial fibrillation (AFib), a condition where the heart beats irregularly. Doctors will use pulsed field ablation (PFA) instead of heat or cold to create scars in the heart and block bad signals. They will also use a special 3D ultrasound syste…

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests a new way to treat atrial fibrillation (AFib) using short electrical pulses instead of heat. The goal is to block abnormal heart signals in a specific area called the mitral isthmus. Thirty adults with AFib will receive this treatment during a standard procedure …

This study tests whether adding extra ablation to standard treatment can help people with persistent atrial fibrillation (a type of irregular heartbeat). About 350 adults will be randomly assigned to receive either standard ablation or standard ablation plus isolation of the left…

This study compares two heart procedures for people with persistent atrial fibrillation (AFib) lasting 6 months to 3 years. One group gets standard pulmonary vein isolation (PVI) ablation, while the other gets PVI plus an extra ablation on the Bachmann bundle. The goal is to see …

This study tests a new device that uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. About 320 adults with AF will receive this procedure to see if it safely restores normal heart rhythm for at least a year. The goal is to reduce sympt…

This study follows 30 adults with paroxysmal atrial fibrillation (PAF) who have or will get a special pacemaker. The pacemaker can detect irregular heartbeats early and send a painless pacing pulse to stop them. It also sends data to doctors remotely. Researchers will check how w…

This clinical trial tests whether giving two electrical shocks at once (dual shock) is better than the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation. About 177 participants will be randomly assigned to receive either a stand…

This study tests whether taking a daily probiotic capsule for 12 weeks can reduce the chance of atrial fibrillation (AF) returning in people who have just had a cardioversion (a procedure to restore normal heart rhythm). Fifty-six adults aged 40 and older with persistent AF will …

This study compares a newer pacing method called Left Bundle Branch Area Pacing (LBBAP) with the standard coronary sinus pacing for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if LBBAP better imp…

This early study tests a special cap that shines near-infrared light on the heads of infants who have had a cardiac arrest in the hospital. The light is meant to reduce brain injury caused when blood flow returns. The trial will include 30 infants with heart disease and will chec…

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (a type of irregular heartbeat) in people with heart failure who already need a pacemaker or defibrillator. About 110 participants will be randomly assigned to recei…

This study looks at whether metabolic surgery (like gastric bypass) can reduce the severity of atrial fibrillation (AF), a common heart rhythm problem, in people with obesity. About 100 adults with AF and a BMI between 35 and 65 will be randomly assigned to either surgery or medi…

This study tests whether staying alcohol-free for six months after a heart ablation procedure can reduce the return of atrial fibrillation (AF), a common heart rhythm problem. Researchers will enroll 414 adults who drink at least three alcoholic beverages per week and are schedul…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This trial will enroll about 3,200 people with paroxysmal atrial fibrillation (AF) to see if using a smartwatch to continuously track AF burden can guide earlier and better treatment. Participants will be monitored with a wearable device, and if their AF burden is high, doctors w…

This study tests whether adding acupuncture to standard care can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who have already had a catheter ablation. About 120 adults aged 20 to 75 will be randomly assigned to receive either acupunctur…

This study looks at whether people with atrial fibrillation who have had a successful heart ablation and also have a heart stent can safely stop taking blood thinners. Participants who maintain a normal heart rhythm for at least a year after ablation will either continue blood th…

This study compares two common heart rate-lowering drugs, verapamil and metoprolol, in 436 adults with paroxysmal atrial fibrillation (AF). It also tests whether using a smartwatch for self-care can reduce hospital visits and improve symptoms. The goal is to find better ways to m…

This study will test whether adding fexuprazan, a stomach acid reducer, to standard blood thinners can prevent upper gastrointestinal bleeding in people with atrial fibrillation. About 1,000 high-risk participants will be randomly assigned to receive either the combination therap…

This study tests a telemedicine program for people aged 65-80 with both atrial fibrillation and heart failure living in rural China. Village clinics are randomly assigned to offer either standard care or a program that includes a digital health system, a smartwatch for monitoring…

This study tests a device called CLAAS that closes a small pouch in the heart (left atrial appendage) to prevent strokes in people with atrial fibrillation. About 300 adults at high risk of stroke will get the device under conscious sedation (awake but relaxed). The goal is to se…

This study tests a new, small pacemaker that doesn't need wires (leads) to help people with a slow heartbeat. About 15 adults with certain heart rhythm problems will get the device to see if it's safe and works well. The pacemaker is placed directly in the heart to keep the beat …

This study will test a combined procedure in 150 people with atrial fibrillation (AFib) who are at risk for stroke. Doctors will use pulse field ablation to correct the heart's rhythm and then close off a small pouch in the heart (the left atrial appendage) to prevent blood clots…

This early study tests a new, wire-free pacemaker (ALPS) in 10 people with bradycardia (slow heart rate). The goal is to see if it is safe and works well. Participants will be monitored for device-related problems and how well the pacemaker controls their heart rhythm.

This early study tests a new device (LAmbre II) that closes a small pouch in the heart called the left atrial appendage in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. Ten participants will be followed for abo…

This study will compare different pulse field ablation systems used to treat atrial fibrillation (AF), a common heart rhythm problem. Over 1,100 patients will receive one of the standard treatments depending on the time period they are treated. Researchers will track whether AF r…

This study compares two blood thinners, apixaban and warfarin, in 120 adults with atrial fibrillation who recently had heart valve repair or replacement. The goal is to see if apixaban causes fewer major bleeding events while still preventing blood clots. Participants will be fol…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study compares two ablation procedures for people with persistent atrial fibrillation (AF), a heart rhythm problem. Half of the 450 participants will get standard treatment (isolating the pulmonary veins), while the other half will get extra ablation lines in the heart. The …

This study looks at two ways to treat atrial fibrillation (a common heart rhythm problem) in people aged 78 and older. One approach uses a procedure called catheter ablation to fix the heart's electrical signals, while the other uses medications to control heart rate or rhythm. R…

This trial tests a procedure called TEER, which uses a clip to repair a leaky heart valve (mitral regurgitation) caused by an irregular heartbeat (atrial fibrillation). The study will include 400 people with moderate-to-severe or severe leakage who still have symptoms despite tak…

This early study tests a new device that uses pulsed electric fields to treat atrial fibrillation (an irregular heartbeat) during planned heart surgery. Sixteen adults will receive the treatment and be followed for 6 months to check safety and whether the heart rhythm stays norma…

This study compares two ablation methods for people with persistent atrial fibrillation (AFib), a heart rhythm problem. One group gets standard treatment (isolating the pulmonary veins), while the other gets that plus extra ablation on the back wall of the heart and a nearby vein…

This study compares the safety of the drug flecainide against standard treatments (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least a year to t…

This study tests whether taking semaglutide (a drug used for diabetes and weight loss) before a standard heart procedure called catheter ablation can help prevent atrial fibrillation from coming back. The trial will include 240 adults with obesity and symptomatic atrial fibrillat…

This study looks at a device called AnchorMan that is placed in the heart to seal a small pouch where clots can form. It is for people with a type of irregular heartbeat (atrial fibrillation) who are at high risk for stroke. The main goal is to see how well the device gets covere…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial tests two different heart pacing leads—one without a hollow core (lumenless) and one with a stylet—to see which works better for left bundle branch pacing. About 288 people with slow heart rhythms will take part. Doctors will use continuous monitoring to guide the lead…

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a successful mitral valve repair. It compares two approaches: catheter ablation (a procedure to fix the heart's electrical signals) versus standard medical care. The goal is to see i…

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This early-stage trial tests whether relaxin, a natural hormone given as a daily injection, can reduce the burden of atrial fibrillation (AF) in 208 veterans who have not responded to standard medications and are scheduled for catheter ablation. The study aims to see if relaxin c…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study tests a new approach for people with end-stage heart failure and permanent atrial fibrillation who are waiting for a heart transplant or heart pump. Participants will receive either a standard implantable defibrillator (ICD) alone or an ICD plus a special pacing lead a…

This trial tests whether dapagliflozin, a drug typically used for diabetes, can reduce the return of atrial fibrillation after a heart ablation procedure. The study focuses on patients with persistent AF and increased epicardial adipose tissue (heart fat), which is linked to high…

This study tests a new shape-adaptive catheter that uses pulsed field ablation to treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. 35 adults with persistent AFib will receive the procedure under general anesthesia. Researchers will check for serious sid…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study compares catheter ablation (a procedure to fix irregular heartbeats) with standard medical care in 646 adults who have both atrial fibrillation and a recent brain bleed. The goal is to see if ablation reduces the risk of death, stroke, or blood clots. Participants must…

This study tests a procedure called pulsed field ablation in 70 people with atrial fibrillation who have already had a left atrial appendage occlusion to prevent stroke. The procedure uses electric pulses to destroy small areas of heart tissue causing the irregular rhythm. Resear…

This study compares two types of medicine for atrial fibrillation (AF), a condition causing irregular heartbeat. About 1,900 adults diagnosed with AF in the past year will be randomly assigned to take either dronedarone or a standard Class Ic drug (like flecainide). Researchers w…

This study tests whether taking semaglutide (Wegovy) for at least three months before a first-time atrial fibrillation ablation can improve heart rhythm outcomes. 200 overweight or obese adults scheduled for ablation will be randomly assigned to either standard care or semaglutid…

This study compares two medical devices (Amplatzer Amulet and LAmbre) used to close a small pouch in the heart called the left atrial appendage. The goal is to reduce stroke risk in people with an irregular heartbeat (atrial fibrillation) who are at high risk for bleeding from bl…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

This study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…

This study tests a temporary pacing technique to slow dangerously fast heart rates in people with atrial fibrillation who cannot use standard medications. Researchers will pace specific nerve fibers near the heart to see if it safely controls heart rate without permanent procedur…

This study looks at two ways to treat atrial fibrillation (AF) that comes back after a first ablation. Patients who still have symptoms despite medication will be randomly assigned to either a repeat ablation or a pacemaker with AV node ablation. The goal is to see which approach…

This study tests if burning extra spots outside the main heart veins can better control persistent atrial fibrillation (a type of irregular heartbeat). About 406 adults having their first ablation will be split into two groups: one gets standard vein isolation, the other gets add…

This study compares two heart procedures for people with paroxysmal atrial fibrillation (AFib), a condition where the heart beats irregularly. One group gets standard ablation to isolate the pulmonary veins, while the other also gets ablation of the superior vena cava using pulse…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests a new procedure called pulsed field ablation (PFA) using the FARAPULSE system to treat people with paroxysmal atrial fibrillation, a type of irregular heartbeat. Researchers will enroll 200 Chinese patients to see if the procedure can safely isolate the veins tha…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests a small, handheld ECG device that records heart activity when held against the chest and sends the data via smartphone to a doctor. Researchers will enroll 594 adults with known or suspected heart conditions to see if the new device is as good as the standard 10-…

This study explores whether an additional CT scan of the heart, taken right after a standard scan for lung clots, can effectively detect blood clots in the left atrial appendage (LAA) in people with atrial fibrillation. Currently, detecting these clots requires a more involved pr…

This study will test whether a small, wearable patch that records heart activity for 7 days can find undiagnosed atrial fibrillation (a common heart rhythm problem) in 30,000 Chinese adults aged 60 and older. Participants will wear the patch and then be followed for up to 10 year…

This study tests a new cardiac MRI method called Free-Running Framework (FRF) that lets patients breathe normally and skips the sticky ECG electrodes. It captures a 3D image of the whole heart in one go, potentially making scans faster and more comfortable. Researchers will compa…

This study will see if community pharmacies can effectively screen people aged 65 and older for atrial fibrillation, a heart condition that raises stroke risk. Trained pharmacists will use a small, portable ECG device to record a 30-second heart reading. If the result is abnormal…

This study tests a new way to find a hidden heart condition called cardiac amyloidosis in people with atrial fibrillation (AF). Researchers will use AI to analyze EKGs and CT scans to spot early signs of the disease. About 500 adults with AF and certain warning signs will be spli…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study tests if a smartphone app and a special bed mat can detect a type of fast heartbeat (supraventricular tachycardia) in children aged 0-10. Researchers will compare these methods to the standard hospital heart monitor. If successful, it could make diagnosis easier and le…

This study will check if a fast, bedside heart ultrasound performed by emergency doctors or interpreted by artificial intelligence can accurately detect heart problems in children who already have heart disease. About 200 children aged 0-21 will be included. The results will be c…

This study will test new ultrasound techniques, combined with artificial intelligence, to more accurately measure heart filling pressure in patients who have both heart failure and atrial fibrillation. Current methods are unreliable for these patients, making diagnosis and treatm…

This study at Mayo Clinic will enroll 100 adults with atrial fibrillation who are taking the drug dofetilide. Researchers will compare a non-invasive magnetic heart scan (magnetocardiography, or MCG) with the standard ECG to see which better predicts safe drug dosing and heart co…

This study will test whether an artificial intelligence (AI) program can accurately detect atrial fibrillation (AF) using data from consumer smartwatches. Researchers will enroll 40 adults with AF who will wear a smartwatch while their heart rhythm is also monitored with standard…

This study tests a new technology that listens to your voice during short phone calls to detect atrial fibrillation, a common heart rhythm problem. Researchers will enroll 40 adults scheduled for a heart reset procedure (cardioversion) and compare voice recordings with standard h…

This study tests whether an artificial intelligence-enhanced ECG (SmartECG-AFrisk) can detect atrial fibrillation (AF) earlier than usual care in 1,230 adults with symptoms like palpitations or dizziness but no prior AF diagnosis. Participants are randomly assigned to either stan…

This study investigates whether screening older veterans (age 65 and older) who have a higher risk of atrial fibrillation—a condition where the heart beats irregularly—can reduce their chances of stroke, heart failure, or death. Participants selected for screening wear a small, w…

This study tests whether colchicine, a drug usually used for gout, can prevent atrial fibrillation (a type of irregular heartbeat) after coronary artery bypass surgery. About 400 adults scheduled for elective bypass will receive either colchicine or a placebo starting 3 days befo…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This trial tests whether two heart medications, metoprolol and amiodarone, can prevent new-onset atrial fibrillation (AFib) in people who develop minor rhythm issues after transcatheter aortic valve replacement (TAVR). About 198 participants will be randomly assigned to one of th…

This study tests whether a telemedicine program, led by village doctors and supported by wearable devices and remote specialists, can prevent heart failure in older adults (65-80) with atrial fibrillation living in rural China. About 1,268 participants will be assigned to either …

This study tests whether the sedative drug dexmedetomidine can prevent new-onset atrial fibrillation (a fast, irregular heartbeat) in the days after mitral valve surgery. Researchers will randomly give 140 adults either the drug or a placebo during and after surgery. The goal is …

This study tests whether an electronic alert in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goa…

This study compares apixaban alone versus apixaban plus clopidogrel for 30 days in people who have had a stroke and have both atrial fibrillation and atherosclerosis. About 586 participants will be randomly assigned to one of the two treatments. The goal is to see if the combinat…

This study will test two different surgical techniques used during heart bypass surgery to see which one better prevents a common complication called atrial fibrillation (irregular heartbeat). The trial will involve 122 adults having their first planned bypass surgery. Researcher…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests whether giving magnesium along with the standard drug metoprolol can quickly lower a dangerously fast heart rate in people with atrial fibrillation or atrial flutter. About 196 adults in the emergency room will receive either magnesium or a placebo, plus metoprol…

This study tests an experimental medicine called BAY 3670549 in 360 adults with atrial fibrillation (an irregular heartbeat). Participants receive a single IV dose of the drug or a placebo to see if it can restore normal heart rhythm without needing an electrical shock procedure.…

This study compares deep sedation using a combination of three drugs (dexmedetomidine, remimazolam, and remifentanil) to standard general anaesthesia for patients undergoing a procedure to treat atrial fibrillation (an irregular heartbeat). The goal is to see if deep sedation can…

This study tests whether starting with a higher shock energy (360 J) is better than a standard 200 J for restoring normal heart rhythm in people with atrial fibrillation. About 400 adults will be randomly assigned to one of three groups, including a personalized approach based on…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study compares two ways to sedate patients during a heart scan and electric shock treatment for atrial fibrillation. Currently, a cardiologist gives mild sedation for the scan, but an anaesthesiologist must give stronger sedation for the shock, causing delays. Researchers wa…

This study looks at 224 adults with a type of irregular heartbeat called paroxysmal atrial fibrillation who are getting a first-time heart procedure called pulsed-field ablation. Researchers want to see if using conscious sedation (being awake but relaxed) is safer than general a…

This study tests whether giving lidocaine through an IV can reduce diaphragm twitching and coughing during a procedure called pulse field ablation for atrial fibrillation. Sixty adults with AFib will be randomly assigned to receive lidocaine or a placebo (saline). The goal is to …

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. Instead of starting with aerobic exercise like walking, participants will first do 2 months of progressive re…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests an investigational nasal spray called etripamil for people with atrial fibrillation (AFib) who experience episodes of dangerously fast heart rate. About 750 adults will be randomly assigned to use either the real spray or a placebo at home when symptoms start. Th…

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study tests a simple mental exercise called episodic future thinking to help people with atrial fibrillation stick to their blood thinner medication. 68 participants will be split into two groups: one gets the future-thinking prompts plus usual care, the other gets usual car…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study will enroll 100 people who have already had a heart procedure (pulsed field ablation) for atrial fibrillation. Participants will wear a BodyGuardian monitor for a period after the procedure to see if it catches any return of irregular heartbeats. The study also asks pa…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study will look at data from 918 adults who had planned heart surgery to find out why some develop atrial fibrillation, a common and serious irregular heartbeat. The researchers will also examine whether newer anesthesia methods, like a nerve block, might help protect agains…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will test a new imaging system called CHORUS IDx in 200 people scheduled for a heart ablation procedure. The system takes pictures inside the heart to help doctors see better during the procedure. The main goal is to check if the device is safe and to collect images th…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study looks at 150 people with persistent atrial fibrillation (a type of irregular heartbeat) who are scheduled for a heart procedure called ablation. Researchers want to see if levels of a protein called BDNF in the blood are linked to signs of heart muscle damage (atrial c…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study will collect real-world information on the VERAFEYE system, a device that creates 3D images of the heart during procedures to treat atrial fibrillation (an irregular heartbeat) and to close the left atrial appendage (a small pouch in the heart). About 50 adults will ta…

This study compares two types of heart ablation for people with persistent atrial fibrillation: pulsed field ablation and radiofrequency ablation. The goal is to see which one causes fewer stomach problems after the procedure. Twenty participants will be matched by age and health…

This study will compare five different pulsed field ablation systems used to treat atrial fibrillation (an irregular heartbeat). The goal is to see which system causes the fewest tiny clots (microemboli) that travel to the brain during the procedure. One hundred adults with atria…

This study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study will look at 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) to understand why AF is more common and harder to treat in HCM. Researchers will measure electrical signals in the heart and use advanced imaging. The goal is to find clues …

This study looks at how a new type of heart ablation (pulsed-field ablation) changes the heart's structure in people with atrial fibrillation. Researchers will use MRI scans before and 4 months after the procedure to measure scarring and function. About 39 adults with persistent …

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This study will check how well heart failure and atrial fibrillation patients take their medicines after being admitted to the coronary care unit. Researchers will interview 250 adults to understand their medication beliefs and whether their prescriptions are appropriate. The goa…

This observational study will follow 10,000 people with atrial fibrillation for 24 months. Researchers will use smartwatch data to measure how much time the heart is in AF (AF burden) and see if that predicts strokes or blood clots. The goal is to find a clear threshold where blo…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study tests whether an artificial intelligence (AI) analysis of a simple electrocardiogram (ECG) can safely replace routine heart ultrasound (echocardiography) in managing atrial fibrillation (AF). About 1,724 adults with AF will be randomly assigned to either AI-ECG guided …

This pilot study tests a web-based decision aid for Black and White patients with atrial fibrillation who need to choose whether to take blood thinners to prevent strokes. The tool explains risks and benefits and asks about personal preferences. The study will check if the tool i…

This study will test a new software system that measures tiny electrical signals in the heart after a procedure called pulsed field ablation, used to treat atrial fibrillation (an irregular heartbeat). Researchers will enroll 30 adults with AF who are already scheduled for ablati…

This study will follow 300 people having planned coronary bypass surgery to see if the amount of belly fat they carry affects their risk of developing atrial fibrillation (a type of irregular heartbeat) after the operation. Before surgery, doctors will use ultrasound to measure t…

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This study looks at whether a special MRI scan can predict if patients will develop an irregular heartbeat (atrial fibrillation) after heart bypass surgery. About 100 adults scheduled for bypass will get an MRI before surgery and wear a heart monitor for a year. The goal is to fi…

This study will test whether an artificial intelligence (AI) tool can better predict stroke risk in 1,000 people aged 65-95 with atrial fibrillation, compared to current methods. The AI analyzes health records and heart data to identify high-risk individuals early. The goal is to…

This registry will follow 3,500 adults with atrial fibrillation who have a low risk of stroke. Researchers will track complications like stroke and hospitalizations over time to see how patients are managed in everyday medical practice. The goal is to better understand outcomes a…

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers caused by atrial fibrillation. Researchers will compare CT scans taken before and 3 months after the procedure in 200 adults. T…

This study aims to see if artificial intelligence can predict serious heart rhythm problems, like atrial fibrillation, after high-risk surgeries. Researchers will record ECGs from 300 adults before surgery and analyze over 200 heart cycle parameters to find the best prediction me…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study follows 700 cancer patients who take blood thinners and are scheduled for surgery or medical procedures. Researchers will track how often major bleeding or clotting events occur within 30 days after the procedure. The goal is to see if current blood thinner management …

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study will implant a small heart monitor under the skin of 100 people with moderate-to-severe mitral valve regurgitation who have few or no symptoms. The device will track heart rhythms for up to three years to find hidden atrial fibrillation that standard tests might miss. …

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults having planned heart surgery. Researchers will analyze this information to find markers that could predict complications like delirium, bleeding, kidney injury, and irregular heartbeat.…

This study uses CT scans to compare heart fat and chamber size in people with and without atrial fibrillation (AF). Researchers will enroll 600 adults to see if fat distribution differs between those with normal rhythm, occasional AF, and persistent AF. No drugs or treatments are…

This study will follow about 3,500 adults in China who have atrial fibrillation (an irregular heartbeat) along with metabolic disorders like obesity, diabetes, or high cholesterol. Researchers want to learn how these combined conditions affect risks for stroke, heart failure, and…

This study looks at 460 adults who need a pacemaker but have never had atrial fibrillation. Researchers will compare three pacing approaches to see which one best reduces brief, device-detected atrial high-rate episodes over two years. The goal is to find out if pacing the heart'…

This study tests a new software module that analyzes heart signals during a procedure called pulsed field ablation, used to treat atrial fibrillation. The goal is to see if the software can accurately tell doctors when the targeted heart veins are fully isolated. One hundred adul…

This study will follow 500 people with dual-chamber pacemakers to see how the pacemaker's programming affects the development of permanent atrial fibrillation (AF), a common heart rhythm problem. Researchers will track AF episodes, quality of life, hospitalizations, and deaths ov…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study tests a small, sticky patch that records heart rhythms in hospitalized patients who need continuous monitoring. The patch sends data to a central system for real-time alerts and later review. Researchers want to see if it helps doctors make faster decisions about treat…

This study looks at whether people with certain heart rhythm disorders also carry genetic variants linked to a rare muscle condition called non-dystrophic myotonia. Researchers will review medical records of 570 participants and invite some for a neurological exam and electromyog…

This study tests whether a WhatsApp-based chatbot can help people recovering from atrial fibrillation ablation. About 76 adults will either use the chatbot to report symptoms and well-being for 3 months or receive standard hospital follow-up. The goal is to see if the chatbot is …

This study looks at 40 adults with atrial fibrillation and heart failure to see if lowering their resting heart rate from 100-110 bpm to a more normal level improves exercise ability and quality of life. Participants will do treadmill tests before and after either a cardioversion…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…

This study will follow 1,100 people with atrial fibrillation who have a pulsed field ablation procedure. The goal is to find out which patient traits and procedure details make a repeat ablation more likely. Researchers will track heart rhythm problems and side effects for one ye…

This study looks at 700 people having their first heart ablation for atrial fibrillation to see if men and women have different heart structures and outcomes. Researchers will compare anatomy, procedure details, and how well the treatment works after 12 months. The goal is to und…