New blood thinner aims to cut bleeding risk in AF patients

NCT ID NCT04755283

Ongoing Disease control Sponsor: Anthos Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 study compares abelacimab, a new biologic blood thinner, to the standard drug rivaroxaban in 1,287 people with atrial fibrillation who are at moderate-to-high risk of stroke. The goal is to see if abelacimab causes fewer major or clinically relevant bleeding events while still preventing strokes. Participants receive either abelacimab or rivaroxaban, and researchers track bleeding rates over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: abelacimab (a biologic blood thinner)
What this could lead to: If successful, abelacimab could offer a safer blood-thinning option for people with atrial fibrillation, reducing bleeding risks while still preventing strokes.
What could go wrong: This is a mid-stage trial with 1,287 participants, so results are not final. The drug may still cause bleeding or fail to prevent strokes as well as rivaroxaban.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF) STROKE

Contacts and locations

Locations

Anthos Investigative Site

Huntsville, Alabama, 35801, United States
Anthos Investigative Site

Mobile, Alabama, 36608, United States
Anthos Investigative Site

Stamford, Connecticut, 06905, United States
Anthos Investigative Site

Clearwater, Florida, 33756, United States
Anthos Investigative Site

Daytona Beach, Florida, 32114-2321, United States
Anthos Investigative Site

Largo, Florida, 33777, United States
Anthos Investigative Site

Safety Harbor, Florida, 34695, United States
Anthos Investigative Site

Saint Augustine, Florida, 32086, United States
Anthos Investigative Site

Johns Creek, Georgia, 30024, United States
Anthos Investigative Site

Owensboro, Kentucky, 42303, United States
Anthos Investigative Site

Baltimore, Maryland, 21229-5222, United States
Anthos Investigative Site

Salisbury, Maryland, 21804, United States
Anthos Investigative Site

Framingham, Massachusetts, 01701, United States
Anthos Investigative Site

Haverhill, Massachusetts, 01830, United States
Anthos Investigative Site

Lansing, Michigan, 48912, United States
Anthos Investigative Site

Sewell, New Jersey, 08080, United States
Anthos Investigative Site

Poughkeepsie, New York, 12601, United States
Anthos Investigative Site

Southampton, New York, 11968, United States
Anthos Investigative Site

Lenoir, North Carolina, 28645, United States
Anthos Investigative Site

Fargo, North Dakota, 58104, United States
Anthos Investigative Site

Oklahoma City, Oklahoma, 73135, United States
Anthos Investigative Site

Camp Hill, Pennsylvania, 17011, United States
Anthos Investigative Site

Kingsport, Tennessee, 37660, United States
Anthos Investigative Site

Kingwood, Texas, 77339, United States
Anthos Investigative Site

Odessa, Texas, 79761-5133, United States
Anthos Investigative Site

Tomball, Texas, 77375, United States
Anthos Investigative Site

Falls Church, Virginia, 22042, United States
Anthos Investigative Site

Manassas, Virginia, 20109, United States
Anthos Investigative Site

Cambridge, Ontario, N1R 7R1, Canada
Anthos Investigative Site

Greater Sudbury, Ontario, P3B 4H5, Canada
Anthos Investigative Site

Oshawa, Ontario, L1J2K1, Canada
Anthos Investigative Site

Greenfield Park, Quebec, J4V 2G8, Canada
Anthos Investigative Site

Montreal, Quebec, H1T 3Y7, Canada
Anthos Investigative Site

Brandýs nad Labem, Central Bohemia, 250 01, Czechia
Anthos Investigative Site

Poděbrady, Central Bohemia, 29001, Czechia
Anthos Investigative Site

Příbram, Central Bohemia, 261 01, Czechia
Anthos Investigative Site

Slaný, Central Bohemia, 274 01, Czechia
Anthos Investigative Site

Mariánské Lázně, KA, 353 01, Czechia
Anthos Investigative Site

Trutnov, KR, 541 01, Czechia
Anthos Investigative Site

Liberec, LB, 460 01, Czechia
Anthos Investigative Site

Česká Lípa, LI, 470 01, Czechia
Anthos Investigative Site

Liberec, LI, 460 01, Czechia
Anthos Investigative Site

Pardubice, PA, 530 02, Czechia
Anthos Investigative Site

Prague, PR, 10100, Czechia
Anthos Investigative Site

Prague, PR, 110 00, Czechia
Anthos Investigative Site

Prague, PR, 158 00, Czechia
Anthos Investigative Site

Kroměříž, ZL, 767 01, Czechia
Anthos Investigative Site

Holešov, Zlín, 769 01, Czechia
Anthos Investigative Site

Orosháza, BE, 5900, Hungary
Anthos Investigative Site

Baja, BK, 6500, Hungary
Anthos Investigative Site

Budapest, BP, 1036, Hungary
Anthos Investigative Site

Budapest, BP, 1122, Hungary
Anthos Investigative Site

Budapest, BU, 1033, Hungary
Anthos Investigative Site

Budapest, BU, 1134, Hungary
Anthos Investigative Site

Székesfehérvár, FE, 8000, Hungary
Anthos Investigative Site

Debrecen, HB, 4025, Hungary
Anthos Investigative Site

Kaposvár, SO, 7400, Hungary
Anthos Investigative Site

Balatonfüred, VE, 8230, Hungary
Anthos Investigative Site

Balatonfüred, VM, 8230, Hungary
Anthos Investigative Site

Gdynia, GDY, 81-423, Poland
Anthos Investigative Site

Chrzanów, Lesser Poland Voivodeship, 32-500, Poland
Anthos Investigative Site

Krakow, Lesser Poland Voivodeship, 31-202, Poland
Anthos Investigative Site

Wroclaw, Lower Silesian Voivodeship, 51-162, Poland
Anthos Investigative Site

Żarów, Lower Silesian Voivodeship, 58-130, Poland
Anthos Investigative Site

Lublin, Lublin Voivodeship, 20-001, Poland
Anthos Investigative Site

Zamość, Lubusz Voivodeship, 22-400, Poland
Anthos Investigative Site

Płock, Masovian Voivodeship, 09-402, Poland
Anthos Investigative Site

Warsaw, Masovian Voivodeship, 02-097, Poland
Anthos Investigative Site

Warsaw, Masovian Voivodeship, 04-628, Poland
Anthos Investigative Site

Przemyśl, Podkarpackie Voivodeship, 37-700, Poland
Anthos Investigative Site

Gdynia, Pomeranian Voivodeship, 81-157, Poland
Anthos Investigative Site

Bielsko-Biala, Silesian Voivodeship, 43-316, Poland
Anthos Investigative Site

Dąbrowa Górnicza, Silesian Voivodeship, 41-300, Poland
Anthos Investigative Site

Ruda Śląska, Silesian Voivodeship, 41-710, Poland
Anthos Investigative Site

Tychy, Silesian Voivodeship, 43-100, Poland
Anthos Investigative Site

Elblag, Warmian-Masurian Voivodeship, 82-300, Poland
Anthos Investigative Site

Lodz, Łódź Voivodeship, 92-213, Poland
Anthos Investigative Site

Seogu, Busan, 49201, South Korea
Anthos Investigative Site

Seongnam-si, Gyeonggi-do, 13496, South Korea
Anthos Investigative Site

Seongnam-si, Gyeonggi-do, 13620, South Korea
Anthos Investigative Site

Seoul, Seoul, 158-710, South Korea
Anthos Investigative Site

Seoul, Seoul, 3080, South Korea
Anthos Investigative Site

Seoul, Seoul, 3722, South Korea
Anthos Investigative Site

Taipei, HSZ, 30071, Taiwan
Anthos Investigative Site

Hualien City, HUA, 970, Taiwan
Anthos Investigative Site

Yilan, ILA, 26058, Taiwan
Anthos Investigative Site

Kaohsiung City, KHH, 807, Taiwan
Anthos Investigative Site

Taipei, TPE, 11217, Taiwan
Anthos Investigative Site

Taipei, TPE, 116, Taiwan
Anthos Investigative Site

Tiachung, TXG, 404, Taiwan
Anthos Investigative Site (4002)

Nyíregyháza, SZ, 4400, Hungary
Anthos Investigative Site (4003)

Nyíregyháza, SZ, 4400, Hungary

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