New risk score tool aims to cut strokes in heart condition patients
NCT ID NCT03753490
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether using a personalized risk score (ABC-score) to guide treatment can lower the chance of stroke or death in people with atrial fibrillation, a common heart rhythm problem. About 3,900 participants are randomly assigned to either standard care or treatment based on their ABC-risk scores. The goal is to see if tailored recommendations for blood thinners and other therapies improve survival without major bleeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ABC score-guided therapy (personalized treatment recommendations based on biomarker-based risk scores)
What this could lead to
If successful, this could provide a more effective way to prevent strokes and deaths in people with atrial fibrillation by tailoring treatments to individual risk.
What could go wrong
This is a large trial but still early in testing a decision-support tool, not a drug. The approach may not significantly improve outcomes over standard care, and results may not apply to all patient groups.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Uppsala University Hospital
Uppsala, Sweden