Freezing heart tissue: new balloon trial for AFib patients

NCT ID NCT05905835

Ongoing Disease control Sponsor: Synaptic Medical Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This trial tests a new device called the Synaptic Cryoablation System, which uses a balloon to freeze small areas of the heart and correct irregular heartbeats in people with paroxysmal atrial fibrillation. 128 participants will receive the treatment and be followed for 12 months. The goal is to see if it safely stops abnormal heart rhythms and improves symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Synaptic Cryoablation System (a device that freezes heart tissue to correct irregular heartbeats)
What this could lead to: If successful, this could offer a new, effective option for controlling atrial fibrillation and reducing symptoms without long-term medication.
What could go wrong: This is an early-stage trial with only 128 participants, so results may not apply to everyone. Risks include procedure-related complications like heart damage or stroke.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation paroxysmal atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAROXYSMAL ATRIAL FIBRILLATION

Contacts and locations

Locations

Banner University Medical Center

Phoenix, Arizona, 85006, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Christus Health Frances Hospital

Tyler, Texas, 75701, United States
Dignity Health Arizona Research Enterprise

Phoenix, Arizona, 85006, United States
Mercy General Hospital

Sacramento, California, 95819, United States
Northwell Health - Lenox Hill Hospital

New York, New York, 10075, United States
St. Bernard's Heart & Vascular

Jonesboro, Arkansas, 72401, United States
St. Luke's Mid America

Kansas City, Missouri, 64111, United States
VCU Pauley Heart Center

Richmond, Virginia, 23298, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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