New heart mapping technique could improve ablation for persistent AF
NCT ID NCT07187115
First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This global trial compares two ablation strategies for people with persistent atrial fibrillation (AF) that hasn't responded to medication. One group gets standard ablation of the pulmonary veins and back wall of the left atrium. The other group gets ablation guided by a special mapping system (electrographic flow mapping) to target additional problem areas. The study aims to see if the mapping-guided approach is as safe and effective as the standard method. About 699 participants will be followed for one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pulsed field ablation (a procedure using electrical pulses to destroy heart tissue causing abnormal rhythms)
What this could lead to
If successful, this could offer a more targeted and potentially safer ablation approach for people with persistent atrial fibrillation, reducing the need for repeat procedures.
What could go wrong
This is a large but early-stage comparison trial; the new mapping technique may not prove superior to the standard approach. As with any heart procedure, risks include bleeding, infection, or heart rhythm complications.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AZORG
ACTIVE_NOT_RECRUITINGAalst, 9300, Belgium
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Alta Bates Summit Medical Center-Hospital
NOT_YET_RECRUITINGOakland, California, 94609, United States
Contact Email: •••••@•••••
Contact
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Arrhythmia Research Group
ACTIVE_NOT_RECRUITINGJonesboro, Arkansas, 72401, United States
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Banner University Medical Center
NOT_YET_RECRUITINGPhoenix, Arizona, 85008, United States
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Baptist Health Lexington
NOT_YET_RECRUITINGLexington, Kentucky, 40503, United States
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Beth Israel Deaconess Medical Center-Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
Contact
Contact
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Centre Hôpital Universitaire Rouen, Hôpital Charles Nicolle
NOT_YET_RECRUITINGRouen, 76000, France
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Christus Trinity Mother Frances Health System
ACTIVE_NOT_RECRUITINGTyler, Texas, 75701, United States
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Cleveland Clinic Foundation
ACTIVE_NOT_RECRUITINGCleveland, Ohio, 44195, United States
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Clinica Universidad de Navarra
ACTIVE_NOT_RECRUITINGPamplona, Navarre, 31008, Spain
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Emory University Hospital
ACTIVE_NOT_RECRUITINGAtlanta, Georgia, 30308, United States
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Endeavor Hospital
NOT_YET_RECRUITINGGlenview, Illinois, 60026, United States
Contact Email: •••••@•••••
Contact
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Erasmus MC - University Medical Center Rotterdam
RECRUITINGRotterdam, 3015, Netherlands
Contact Email: •••••@•••••
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Good Samaritan - Suffern
NOT_YET_RECRUITINGSuffern, New York, 10901, United States
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Grandview Medical Center
NOT_YET_RECRUITINGBirmingham, Alabama, 35243, United States
Contact
Contact Email: •••••@•••••
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Hartcentrum Hasselt Jessa Ziekenhuis Campus Virga Jesse
ACTIVE_NOT_RECRUITINGHasselt, 3500, Belgium
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Hospital Clinic de Barcelona
NOT_YET_RECRUITINGBarcelona, Catalonia, 08036, Spain
Contact
Contact Email: •••••@•••••
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Hospital of the University of Pennsylvania
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Email: •••••@•••••
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Inova Fairfax Hospital
WITHDRAWNFalls Church, Virginia, 22042, United States
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MVZ CCB Frankfurt und Main-Taunus GbR
RECRUITINGFrankfurt, 60431, Germany
Contact
Contact Email: •••••@•••••
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Massachusetts General Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
Contact
Contact
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Mercy Gilbert Medical Center
NOT_YET_RECRUITINGGilbert, Arizona, 85297, United States
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Mercy Hospital Medical Center
NOT_YET_RECRUITINGWest Des Moines, Iowa, 50266, United States
Contact
Contact Email: •••••@•••••
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Mission Hospital
NOT_YET_RECRUITINGAsheville, North Carolina, 28801, United States
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Mount Sinai Medical Center
ACTIVE_NOT_RECRUITINGNew York, New York, 10029, United States
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Ohio State University Medical Center
ACTIVE_NOT_RECRUITINGColumbus, Ohio, 43210, United States
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OhioHealth Research and Innovation Institute - Riverside Methodist Hospital
NOT_YET_RECRUITINGColumbus, Ohio, 43214, United States
Contact
Contact Email: •••••@•••••
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Pacific Heart Institute
ACTIVE_NOT_RECRUITINGSanta Monica, California, 90404, United States
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Piedmont Athens Regional
RECRUITINGAthens, Georgia, 30606, United States
Contact Email: •••••@•••••
Contact
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Presbyterian University of Pennsylvania Medical Center
WITHDRAWNPittsburgh, Pennsylvania, 15213, United States
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Prince of Wales Hosptial
ACTIVE_NOT_RECRUITINGShatin, Hong Kong, Hong Kong
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Sacred Heart Medical Center at Riverbend
WITHDRAWNSpringfield, Oregon, 97477, United States
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Sentara Norfolk General Hospital
NOT_YET_RECRUITINGNorfolk, Virginia, 23507, United States
Contact
Contact Email: •••••@•••••
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St. Antonius Ziekenhuis
NOT_YET_RECRUITINGNieuwegein, 3435, Netherlands
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St. John's Hospital
NOT_YET_RECRUITINGSpringfield, Illinois, 62769, United States
Contact Email: •••••@•••••
Contact
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St. Luke's Boise Medical Center
ACTIVE_NOT_RECRUITINGBoise, Idaho, 83702, United States
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St. Mary's Duluth Clinic Regional Heart Center
NOT_YET_RECRUITINGDuluth, Minnesota, 55805, United States
Contact
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St. Vincent's Medical Center
NOT_YET_RECRUITINGJacksonville, Florida, 32204, United States
Contact
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Stanford University Medical Center
NOT_YET_RECRUITINGPalo Alto, California, 94304, United States
Contact Email: •••••@•••••
Contact
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Texas Cardiac Arrhythmia Research Foundation
ACTIVE_NOT_RECRUITINGAustin, Texas, 78705, United States
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Email: •••••@•••••
Contact
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William Beaumont Hospital
ACTIVE_NOT_RECRUITINGRoyal Oak, Michigan, 48073, United States