New heart mapping technique could improve ablation for persistent AF

NCT ID NCT07187115

Ongoing Disease control Sponsor: Boston Scientific Corporation Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 5 times

Summary

This global trial compares two ablation strategies for people with persistent atrial fibrillation (AF) that hasn't responded to medication. One group gets standard ablation of the pulmonary veins and back wall of the left atrium. The other group gets ablation guided by a special mapping system (electrographic flow mapping) to target additional problem areas. The study aims to see if the mapping-guided approach is as safe and effective as the standard method. About 699 participants will be followed for one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pulsed field ablation (a procedure using electrical pulses to destroy heart tissue causing abnormal rhythms)
What this could lead to: If successful, this could offer a more targeted and potentially safer ablation approach for people with persistent atrial fibrillation, reducing the need for repeat procedures.
What could go wrong: This is a large but early-stage comparison trial; the new mapping technique may not prove superior to the standard approach. As with any heart procedure, risks include bleeding, infection, or heart rhythm complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF) PERSISTANT ATRIAL FIBRILLATION

Contacts and locations

Locations

AZORG

Aalst, 9300, Belgium
Arrhythmia Research Group

Jonesboro, Arkansas, 72401, United States
Christus Trinity Mother Frances Health System

Tyler, Texas, 75701, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Emory University Hospital

Atlanta, Georgia, 30308, United States
Hartcentrum Hasselt Jessa Ziekenhuis Campus Virga Jesse

Hasselt, 3500, Belgium
Mount Sinai Medical Center

New York, New York, 10029, United States
Ohio State University Medical Center

Columbus, Ohio, 43210, United States
Pacific Heart Institute

Santa Monica, California, 90404, United States
Piedmont Athens Regional

Athens, Georgia, 30606, United States
Prince of Wales Hosptial

Shatin, Hong Kong, Hong Kong
St. Luke's Boise Medical Center

Boise, Idaho, 83702, United States
Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, 78705, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States

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