New heart procedure could improve treatment for persistent AF
NCT ID NCT07187115
First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 22 times
Summary
This study compares two heart procedures for people with persistent atrial fibrillation (AF), a condition where the heart beats irregularly. Both procedures use pulsed field ablation to destroy small areas of heart tissue causing the problem. One group gets standard treatment plus ablation of the back wall of the heart's left atrium, while the other gets standard treatment plus ablation of extra sources identified by a special mapping system. The goal is to see which approach is safer and more effective at restoring normal heart rhythm. About 699 adults with symptomatic AF that hasn't improved with medication will participate.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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AZORG
RECRUITINGAalst, 9300, Belgium
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Alta Bates Summit Medical Center-Hospital
RECRUITINGOakland, California, 94609, United States
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Arrhythmia Research Group
RECRUITINGJonesboro, Arkansas, 72401, United States
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Banner University Medical Center
NOT_YET_RECRUITINGPhoenix, Arizona, 85008, United States
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Baptist Health Lexington
NOT_YET_RECRUITINGLexington, Kentucky, 40503, United States
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Centre Hôpital Universitaire Rouen, Hôpital Charles Nicolle
NOT_YET_RECRUITINGRouen, 76000, France
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Christus Trinity Mother Frances Health System
RECRUITINGTyler, Texas, 75701, United States
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
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Clinica Universidad de Navarra
RECRUITINGPamplona, Navarre, 31008, Spain
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Emory University Hospital
NOT_YET_RECRUITINGAtlanta, Georgia, 30308, United States
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Endeavor Hospital
NOT_YET_RECRUITINGGlenview, Illinois, 60026, United States
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Erasmus MC - University Medical Center Rotterdam
NOT_YET_RECRUITINGRotterdam, 3015, Netherlands
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Good Samaritan - Suffern
NOT_YET_RECRUITINGSuffern, New York, 10901, United States
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Grandview Medical Center
NOT_YET_RECRUITINGBirmingham, Alabama, 35243, United States
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Hartcentrum Hasselt Jessa Ziekenhuis Campus Virga Jesse
RECRUITINGHasselt, 3500, Belgium
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Contact Email: •••••@•••••
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Hospital Clinic de Barcelona
NOT_YET_RECRUITINGBarcelona, Catalonia, 08036, Spain
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Hospital of the University of Pennsylvania
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Contact Email: •••••@•••••
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Inova Fairfax Hospital
WITHDRAWNFalls Church, Virginia, 22042, United States
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MVZ CCB Frankfurt und Main-Taunus GbR
NOT_YET_RECRUITINGFrankfurt, 60431, Germany
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact
Contact
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Mercy Gilbert Medical Center
NOT_YET_RECRUITINGGilbert, Arizona, 85297, United States
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Mercy Hospital Medical Center
NOT_YET_RECRUITINGWest Des Moines, Iowa, 50266, United States
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Mission Hospital
NOT_YET_RECRUITINGAsheville, North Carolina, 28801, United States
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Mount Sinai Medical Center
NOT_YET_RECRUITINGNew York, New York, 10029, United States
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Ohio State University Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
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OhioHealth Riverside Methodist Hospital
NOT_YET_RECRUITINGColumbus, Ohio, 43214, United States
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Pacific Heart Institute
RECRUITINGSanta Monica, California, 90404, United States
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Piedmont Athens Regional
NOT_YET_RECRUITINGAthens, Georgia, 30606, United States
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Presbyterian University of Pennsylvania Medical Center
WITHDRAWNPittsburgh, Pennsylvania, 15213, United States
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Sacred Heart Medical Center at Riverbend
WITHDRAWNSpringfield, Oregon, 97477, United States
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Sentara Norfolk General Hospital
NOT_YET_RECRUITINGNorfolk, Virginia, 23507, United States
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St. Antonius Ziekenhuis
NOT_YET_RECRUITINGNieuwegein, 3435, Netherlands
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St. Luke's Boise Medical Center
RECRUITINGBoise, Idaho, 83702, United States
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St. Mary's Duluth Clinic Regional Heart Center
NOT_YET_RECRUITINGDuluth, Minnesota, 55805, United States
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St. Vincent's Medical Center
NOT_YET_RECRUITINGJacksonville, Florida, 32204, United States
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Stanford University Medical Center
NOT_YET_RECRUITINGPalo Alto, California, 94304, United States
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Texas Cardiac Arrhythmia Research Foundation
RECRUITINGAustin, Texas, 78705, United States
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Contact Email: •••••@•••••
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University of Pittsburgh Medical Center
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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William Beaumont Hospital
NOT_YET_RECRUITINGRoyal Oak, Michigan, 48073, United States
Conditions
Explore the condition pages connected to this study.