Could a common blood thinner replace warfarin for tricky heart valve patients?
NCT ID NCT04045093
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares dabigatran (Pradaxa) to warfarin for preventing strokes in 370 people with both atrial fibrillation and moderate-to-severe mitral stenosis. Participants are randomly assigned to one of the two blood thinners. The goal is to see if dabigatran is as good as or better than warfarin at preventing strokes, blood clots, heart attacks, and death, while possibly having fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dabigatran etexilate (Pradaxa)
- What this could lead to
- If successful, this could provide a safer, more convenient alternative to warfarin for stroke prevention in atrial fibrillation patients with mitral stenosis.
- What could go wrong
- This is a relatively small, open-label trial, and results may not apply to all patients. Dabigatran may not be as effective or safe as warfarin in this specific population.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ATRIAL FIBRILLATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The University of Hong Kong / Queen Mary Hospital
Hong Kong, Hong Kong
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A tiny neck implant could catch Stroke-Causing clots before they reach the brain
- Could a new injection tame atrial fibrillation?
- Which blood thinner is safer for heart patients? a Head-to-Head test
- Can a cholesterol drug keep atrial fibrillation at bay after ablation?
- Can a One-Two punch fix a leaky heart valve and restore normal rhythm?
- Could a guided Self-Care plan tame atrial Fibrillation's return?