New heart device aims to cut stroke risk in AFib patients

NCT ID NCT06168942

Terminated Disease control Sponsor: Biosense Webster, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Participants must have a high stroke risk score and be recommended for the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atrial fibrillation stroke disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-VALVULAR ATRIAL FIBRILLATION STROKE SYSTEMIC EMBOLISM

Contacts and locations

Locations

ASST Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
AZ Sint Jan Brugge Oostende AV

Bruges, 8000, Belgium
AZORG campus Aalst Moorselbaan

Aalst, 9300, Belgium
Arizona Arrhythmia Research Group Phoenix Cardio Research Group PCRG

Phoenix, Arizona, 85018, United States
Arrhythmia Research Group

Jonesboro, Arkansas, 72401, United States
Ascension via Christi Hospitals Wichita Inc

Wichita, Kansas, 67214, United States
Asklepios Klinik Altona

Hamburg, 22763, Germany
Asklepios Klinik St. Georg

Hamburg, 22587, Germany
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Baylor Scott & White Research Institute at The Heart Hospital Baylor Plano

Plano, Texas, 75093, United States
Bethesda North Hospital Trihealth

Cincinnati, Ohio, 45202, United States
C.H.U. Brugmann

Brussels, 1020, Belgium
CHU Charleroi Chimay

Charleroi, 6042, Belgium
CVC CardioVascular Center Frankfurt

Frankfurt am Main, 60389, Germany
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Centennial Medical Center

Nashville, Tennessee, 37203, United States
Centro Cardiologico Monzino

Milan, 20138, Italy
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Clinica Univ. de Navarra

Pamplona, 31008, Spain
Clinique Pasteur

Toulouse, 31300, France
Columbia University in the City of New York and The New York and Presbyterian Hospital

New York, New York, 10032, United States
East Carolina University

Greenville, North Carolina, 27834, United States
Emory University

Atlanta, Georgia, 30322, United States
Englewood Health

Englewood, New Jersey, 07631, United States
Erasmus MC

Rotterdam, 3015 GD, Netherlands
Fondazione Toscana Gabriele Monasterio CNR

Massa, 54100, Italy
Grandview Medical Center

Birmingham, Alabama, 35243, United States
Heart Rhythm Associates

Shenandoah, Texas, 77380, United States
Hopital Prive Jacques Cartier

Massy, 91300, France
Hosp Clinic de Barcelona

Barcelona, 08036, Spain
Hosp. Alvaro Cunqueiro

Vigo, 36213, Spain
Hosp. Clinico San Carlos

Madrid, 28040, Spain
Hosp. de La Santa Creu I Sant Pau

Barcelona, 08025, Spain
Hospital Universitario de Salamanca

Salamanca, 37007, Spain
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Lindner Clinical Trial Center/Christ Hospital

Cincinnati, Ohio, 45219, United States
Los Robles Regional Medical Center

Thousand Oaks, California, 91360, United States
MVZ CCB Frankfurt und Main Taunus GbR

Frankfurt a.M., 60431, Germany
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Memorial Health University Medical Center

Savannah, Georgia, 31404, United States
Mercy Hospital

Janesville, Wisconsin, 53548, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
NCH Healthcare

North Naples, Florida, 34102, United States
NYU Langone Health

New York, New York, 10016, United States
Nemocnice na Homolce

Prague, 150 30 District 5, Czechia
Northwell Health

Bay Shore, New York, 11706, United States
OC Medical Center

Fountain Valley, California, 92708, United States
Ohio Health

Columbus, Ohio, 43214, United States
Ohio State University

Columbus, Ohio, 43210, United States
Piedmont Healthcare

Atlanta, Georgia, 30309, United States
Policlinico Tor Vergata

Roma, 00133, Italy
Providence Saint John's Health Center and the Pacific Heart Institute

Santa Monica, California, 90404, United States
Rigshospitalet Copenhagen University Hospital

Copenhagen, 2100, Denmark
Sarasota Memorial Hospital

Sarasota, Florida, 34239, United States
Scripps Health

San Diego, California, 92121, United States
St Joseph Hospital and Medical Center

Tacoma, Washington, 98405, United States
St Vincents Medical Center 1

Jacksonville, Florida, 32204, United States
St. Antonius Ziekenhuis Nieuwegein

Nieuwegein, 3435 CM, Netherlands
Stanford Health Care

Palo Alto, California, 94303, United States
Swedish Medical Center

Seattle, Washington, 98122, United States
Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, 78705, United States
Texas Heart Institute

Houston, Texas, 77030, United States
The Kansas City Heart Rhythm Institute

Overland Park, Kansas, 66211, United States
Trident Medical Center

North Charleston, South Carolina, 29406, United States
Tucson Medical Center

Tucson, Arizona, 85712, United States
Univeristy of California Davis Health

Rancho Cordova, California, 95670, United States
Uniwersytecki Szpital Kliniczny w Poznaniu

Poznan, 61 848, Poland
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Vilnius University Hospital Santaros Clinics

Vilnius, 08661, Lithuania
Wake Forest University Health Sciences

Charlotte, North Carolina, 28203, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.