Heart surgery upgrade: new device combo aims to stop AFib before it starts
NCT ID NCT06989775
First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times
Summary
This study tests whether using a special clamp (EnCompass) to create a scar line in the heart and a clip (AtriClip) to close off a small pouch can prevent new atrial fibrillation after heart surgery. The trial will enroll 960 people aged 65 or older who are having planned heart surgery but have never had AFib. Half will get the standard surgery alone, and half will get the standard surgery plus the clamp and clip procedure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Isolator Synergy EnCompass Ablation System and AtriClip LAA Exclusion System
What this could lead to
If it works, this could become a standard preventive step during heart surgery to stop atrial fibrillation from ever starting.
What could go wrong
This is a large trial, but the procedure adds time and risk to surgery. It may not reduce AF enough to justify the extra steps, and long-term benefits are still unknown.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Allegheny-Singer Research Institute
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Ascension Saint Thomas
RECRUITINGNashville, Tennessee, 37205, United States
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Aspirus Hospital
RECRUITINGWausau, Wisconsin, 54401, United States
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Baylor Research Institute - Baylor Scott and White Research Institute
RECRUITINGDallas, Texas, 75204, United States
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Bethesda North Hospital
RECRUITINGCincinnati, Ohio, 45242, United States
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Charleston Area Medical Center
RECRUITINGCharleston, West Virginia, 25304, United States
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
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Corewell Health
RECRUITINGGrand Rapids, Michigan, 49503, United States
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Emory University
RECRUITINGAtlanta, Georgia, 30308, United States
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Hamilton General Hospital
RECRUITINGHamilton, Ontario, L8L 2X2, Canada
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London Health Sciences Centre, University Hospital
RECRUITINGLondon, Ontario, N6A 5A5, Canada
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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MedStar Health Research Institute
RECRUITINGBaltimore, Maryland, 21218, United States
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Montreal Heart Institute
RECRUITINGMontreal, Quebec, H1T 1C8, Canada
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Morton Plant Hospital - BayCare Health System, Inc.
RECRUITINGClearwater, Florida, 33759, United States
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New York Presbyterian Hospital/Columbia University Irving Medical Center
NOT_YET_RECRUITINGNew York, New York, 10032, United States
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Northwell Health
RECRUITINGManhasset, New York, 11030, United States
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611, United States
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Norton Healthcare
RECRUITINGLouisville, Kentucky, 40205, United States
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Orlando Health, Inc.
RECRUITINGOrlando, Florida, 32806, United States
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Piedmont Hospital
RECRUITINGAtlanta, Georgia, 30309, United States
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Sarasota Memorial Hospital
RECRUITINGSarasota, Florida, 34239, United States
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Sharp Memorial Hospital
RECRUITINGSan Diego, California, 92123, United States
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St. Bernards Medical Center
RECRUITINGJonesboro, Arkansas, 72401, United States
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St. Joseph's Hospital - BayCare Health System, Inc.
RECRUITINGClearwater, Florida, 33759, United States
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Trinity Health
RECRUITINGYpsilanti, Michigan, 48197, United States
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Wellstar Health System
RECRUITINGMarietta, Georgia, 30062, United States
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