Heart surgery upgrade: new device combo aims to stop AFib before it starts

NCT ID NCT06989775

Recruiting now Prevention Sponsor: AtriCure, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study tests whether using a special clamp (EnCompass) to create a scar line in the heart and a clip (AtriClip) to close off a small pouch can prevent new atrial fibrillation after heart surgery. The trial will enroll 960 people aged 65 or older who are having planned heart surgery but have never had AFib. Half will get the standard surgery alone, and half will get the standard surgery plus the clamp and clip procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Isolator Synergy EnCompass Ablation System and AtriClip LAA Exclusion System
What this could lead to: If it works, this could become a standard preventive step during heart surgery to stop atrial fibrillation from ever starting.
What could go wrong: This is a large trial, but the procedure adds time and risk to surgery. It may not reduce AF enough to justify the extra steps, and long-term benefits are still unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION, POSTOPERATIVE POST OPERATIVE ATRIAL FIBRILLATION

Contacts and locations

Locations

Allegheny-Singer Research Institute
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Ascension Saint Thomas
RECRUITING

Nashville, Tennessee, 37205, United States
Aspirus Hospital
RECRUITING

Wausau, Wisconsin, 54401, United States
Baylor Research Institute - Baylor Scott and White Research Institute
RECRUITING

Dallas, Texas, 75204, United States
Bethesda North Hospital
RECRUITING

Cincinnati, Ohio, 45242, United States
Charleston Area Medical Center
RECRUITING

Charleston, West Virginia, 25304, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Emory University
RECRUITING

Atlanta, Georgia, 30308, United States
Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
London Health Sciences Centre, University Hospital
RECRUITING

London, Ontario, N6A 5A5, Canada
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
MedStar Health Research Institute
RECRUITING

Baltimore, Maryland, 21218, United States
Montreal Heart Institute
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
Morton Plant Hospital - BayCare Health System, Inc.
RECRUITING

Clearwater, Florida, 33759, United States
New York Presbyterian Hospital/Columbia University Irving Medical Center
NOT_YET_RECRUITING

New York, New York, 10032, United States
Northwell Health
RECRUITING

Manhasset, New York, 11030, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Norton Healthcare
RECRUITING

Louisville, Kentucky, 40205, United States
Orlando Health, Inc.
RECRUITING

Orlando, Florida, 32806, United States
Piedmont Hospital
RECRUITING

Atlanta, Georgia, 30309, United States
Sarasota Memorial Hospital
RECRUITING

Sarasota, Florida, 34239, United States
Sharp Memorial Hospital
RECRUITING

San Diego, California, 92123, United States
St. Bernards Medical Center
RECRUITING

Jonesboro, Arkansas, 72401, United States
St. Joseph's Hospital - BayCare Health System, Inc.
RECRUITING

Clearwater, Florida, 33759, United States
Trinity Health
RECRUITING

Ypsilanti, Michigan, 48197, United States
Wellstar Health System
RECRUITING

Marietta, Georgia, 30062, United States

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