New heart device aims to cut stroke risk without Long-Term blood thinners

NCT ID NCT05147792

Recruiting now Disease control Sponsor: Conformal Medical, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 4 times

Summary

This study tests a new device called CLAAS that is placed in the heart to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 1600 participants will be randomly assigned to get either the new device or one of two already-approved devices. The goal is to see if the new device is as safe and effective at preventing strokes and blood clots, while reducing the need for long-term blood thinner medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atrial fibrillation stroke disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION STROKE

Contacts and locations

Show contact details

Locations

AKFA Medline
ACTIVE_NOT_RECRUITING

Olmazor, Tashkent, 100211, Uzbekistan
Abrazo Arizona Heart Hospital
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85016, United States
AdventHealth Orlando
RECRUITING

Orlando, Florida, 32803, United States
AdventHealth Tampa
RECRUITING

Tampa, Florida, 33613, United States
Albany Medical Center / Capital Cardiology Associates
RECRUITING

Albany, New York, 12208, United States
Arizona Heart Arrhythmia Associates
RECRUITING

Phoenix, Arizona, 85018, United States
Ascension St. Vincent - Carmel, IN
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46260, United States
Ascension St. Vincent's Jacksonville
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32204, United States
Asklepios Klinik-Altona
RECRUITING

Hamburg, 22763, Germany
Banner University Medical Center Phoenix
RECRUITING

Phoenix, Arizona, 85006, United States
Baptist Health Care - Pensacola
RECRUITING

Pensacola, Florida, 32503, United States
Baptist Hospital of Miami
RECRUITING

Miami, Florida, 33176, United States
Baylor Scott & White Research Institute
RECRUITING

Plano, Texas, 75093, United States
Baystate Medical Center
RECRUITING

Springfield, Massachusetts, 01199, United States
Bellin Health
RECRUITING

Green Bay, Wisconsin, 54301, United States
CHI Health / CommonSpirit Research Institute
ACTIVE_NOT_RECRUITING

Omaha, Nebraska, 68124, United States
CHRISTUS Health
RECRUITING

Tyler, Texas, 75701, United States
CHU La Timone, Marseille
RECRUITING

Marseille, 13005, France
CHU de Bordeaux
RECRUITING

Bordeaux, 33604, France
CHU de Toulouse
RECRUITING

Toulouse, 31059, France
Cardiovasculäres Centrum Frankfurt
RECRUITING

Frankfurt, 60389, Germany
Carilion Clinic
RECRUITING

Roanoke, Virginia, 24014, United States
Catholic Medical Center
ACTIVE_NOT_RECRUITING

Manchester, New Hampshire, 03102, United States
CentraCare Heart and Vascular Center
ACTIVE_NOT_RECRUITING

Saint Cloud, Minnesota, 56303, United States
Chapidze Heart Disease Center
ACTIVE_NOT_RECRUITING

Tbilisi, Georgia
Chippenham Hospital
RECRUITING

Richmond, Virginia, 23225, United States
Clinique Pasteur, Toulouse
RECRUITING

Toulouse, 31076, France
Community Memorial Hospital Ventura
RECRUITING

Ventura, California, 93003, United States
Cooper University - Heart House
RECRUITING

Haddon Heights, New Jersey, 08104, United States
Corewell Health
ACTIVE_NOT_RECRUITING

Grand Rapids, Michigan, 49503, United States
Deborah Heart and Lung
RECRUITING

Browns Mills, New Jersey, 08015, United States
Elisabeth Krankenhaus
RECRUITING

Essen, 45138, Germany
Emory University
RECRUITING

Atlanta, Georgia, 30342, United States
Erlanger Health System
ACTIVE_NOT_RECRUITING

Chattanooga, Tennessee, 37403, United States
Grandview Medical Center
RECRUITING

Birmingham, Alabama, 35243, United States
HCA Grand Strand
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Hackensack University Medical Center
ACTIVE_NOT_RECRUITING

Hackensack, New Jersey, 07601, United States
Hartford Health Care St. Vincent's Medical Center
RECRUITING

Bridgeport, Connecticut, 06606, United States
Henry Ford Providence Southfield Hospital
RECRUITING

Southfield, Michigan, 48075, United States
Henry Ford St. John Hospital
RECRUITING

Detroit, Michigan, 48236, United States
HonorHealth
RECRUITING

Scottsdale, Arizona, 85258, United States
Houston Methodist
RECRUITING

Houston, Texas, 77030, United States
Huntington Hospital
RECRUITING

Pasadena, California, 91105, United States
Institut Cardiovasculaire Paris Sud
RECRUITING

Massy, 91300, France
Israeli-Georgian Medical Research Clinic Helsicore
ACTIVE_NOT_RECRUITING

Tbilisi, Georgia
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Kansas City Cardiac Arrhythmia Research, LLC
RECRUITING

Overland, Missouri, 66211, United States
Lahey Hospital & Medical Centeer
RECRUITING

Burlington, Massachusetts, 01805, United States
Lankenau Heart Institute
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Largo Medical Center
RECRUITING

Largo, Florida, 33770, United States
Lexington Medical Center
RECRUITING

West Columbia, South Carolina, 29169, United States
Lifespan Health System
ACTIVE_NOT_RECRUITING

Providence, Rhode Island, 02903, United States
Loma Linda University Health
RECRUITING

Loma Linda, California, 92354, United States
M Health Fairview St. John's Hospital
RECRUITING

Maplewood, Minnesota, 55109, United States
MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medstar Union Memorial Hospital
RECRUITING

Baltimore, Maryland, 21218, United States
Memorial Hermann Memorial City Medical Center
RECRUITING

Houston, Texas, 77094, United States
Midwest Cardiovascular Institute
RECRUITING

Naperville, Illinois, 60540, United States
Mission Hospital
RECRUITING

Asheville, North Carolina, 28801, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Nemocnice Na Homolce
ACTIVE_NOT_RECRUITING

Prague, 150 00, Czechia
New Mexico Heart Institute
RECRUITING

Albuquerque, New Mexico, 87102, United States
North Mississippi Medical Center
RECRUITING

Tupelo, Mississippi, 38801, United States
Northside Hospital, Inc
RECRUITING

Atlanta, Georgia, 30342, United States
Ohio Health Research Institute
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43214, United States
Pacific Heart Institute
RECRUITING

Santa Monica, California, 90405, United States

Contact Email: •••••@•••••
Piedmont Health Institute
RECRUITING

Atlanta, Georgia, 30309, United States
Pima Heart & Vascular
RECRUITING

Tucson, Arizona, 85719, United States
Prisma Health
RECRUITING

Columbia, South Carolina, 29203, United States
ProMedica Toledo Hospital
RECRUITING

Toledo, Ohio, 43606, United States
Republican Specialized Center for Surgery named after V. Vakhidov
ACTIVE_NOT_RECRUITING

Chilanzar, Tashkent, 100115, Uzbekistan
Saint Luke's Hospital of Kansas City
RECRUITING

Kansas City, Missouri, 64111, United States
Sarasota Memorial Health Care System
RECRUITING

Sarasota, Florida, 34239, United States
Sentara Norfolk
ACTIVE_NOT_RECRUITING

Norfolk, Virginia, 23507, United States
South Denver Cardiology Associates
RECRUITING

Littleton, Colorado, 80120, United States
St. Bernard's Medical Center
RECRUITING

Jonesboro, Arkansas, 72401, United States
Tbilisi Heart Center
ACTIVE_NOT_RECRUITING

Tbilisi, Georgia
Tbilisi Heart and Vascular Clinic
ACTIVE_NOT_RECRUITING

Tbilisi, Georgia
Tennova Healthcare - Turkey Creek Medical Center
RECRUITING

Knoxville, Tennessee, 37934, United States
Terrebone - Cardiovascular Institute of the South
RECRUITING

Houma, Louisiana, 70360, United States
TriHealth
RECRUITING

Cincinnati, Ohio, 45242, United States
Trident Medical Center
RECRUITING

North Charleston, South Carolina, 29406, United States
UPMC Harrisburg
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
USF - Tampa General Hospital
RECRUITING

Tampa, Florida, 33620, United States
University of Buffalo / Kaleida Health
RECRUITING

Buffalo, New York, 14203, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23219, United States
Virginia Mason Medical Center
RECRUITING

Seattle, Washington, 98101, United States
WellStar Kennestone Hospital
RECRUITING

Marietta, Georgia, 30062, United States
West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.