New heart procedure could ease dual burden of heart failure and AF

NCT ID NCT05029570

Recruiting now Disease control Sponsor: Daniel Rodríguez Muñoz Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study is testing whether a combination of a special pacemaker (conduction system pacing) and a targeted heart ablation can help people with both heart failure and permanent atrial fibrillation. About 334 participants will be randomly assigned to either receive the procedure or continue with standard heart-rate control medications. The goal is to see if the procedure reduces deaths, hospitalizations, and worsening heart failure over three years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Conduction System Pacing (pacemaker) and Atrioventricular Node Ablation
What this could lead to: If successful, this could offer a more effective treatment strategy for people with heart failure and atrial fibrillation, potentially reducing hospitalizations and improving survival.
What could go wrong: This is a mid-stage trial, so results are not yet proven. The procedure carries risks like bleeding, infection, or heart damage, and may not work better than standard medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION HEART FAILURE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, 28041, Spain

Contact Phone: •••-•••-•••• Email: •••••@•••••

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