HEART FAILURE

This study compared a device called Aquadex, which filters excess fluid from the blood, to standard IV diuretics in 167 hospitalized heart failure patients with fluid overload. The goal was to see which method better prevented heart failure events like rehospitalization. However,…

This early study tested a device that is surgically placed in the belly to continuously remove extra fluid from the body. It was designed for people with advanced heart failure whose bodies no longer respond to water pills. Only 2 patients were enrolled before the study was stopp…

This study tested whether pacing three spots in the heart instead of the usual two could improve cardiac resynchronization therapy (CRT) for people with heart failure. About 30% of patients don't respond well to standard CRT. The trial planned to enroll 36 adults with severe hear…

This study tested an investigational drug called LY3540378 in 332 adults with worsening chronic heart failure where the heart pumps normally but doesn't fill properly (HFpEF). The goal was to see if the drug could improve heart function and safety compared to a placebo. The trial…

This study tested an experimental drug called XXB750 in 136 people with heart failure. The goal was to see if it could improve heart function and symptoms. The trial was terminated early, so the full results are not available.

This study tested a single dose of an experimental antibody called REGN5381 in 89 people with chronic heart failure and reduced pumping ability. The goal was to check safety, how the drug moves in the body, and its effects on heart stress markers. The trial was terminated early, …

This early study tested a new drug called AZD5462 added to the standard medicine dapagliflozin in people with heart failure and moderate kidney disease. Only 8 participants were enrolled before the study was stopped. The goal was to see if the combination is safe and affects how …

This study tested a small, implantable heart pump called the HeartWare MVAD in 11 people with advanced heart failure. The goal was to see if the device could safely help the heart pump blood. However, the trial was stopped early, so we have limited information on how well it work…

This Phase 2 study tested ponsegromab, an experimental drug, against a placebo in 455 adults with heart failure. Participants received injections every four weeks for about nine months. The goal was to see if ponsegromab could improve symptoms and quality of life. The trial was t…

This study looked at whether letting patients manage their own recovery precautions after heart surgery leads to a better quality of life compared to following standard sternal precautions. Ten adults who had heart surgery were followed for up to a year. Researchers checked pain,…

This pilot study tested whether a small wearable sensor called the Spire Health Tag could reliably track heart rate, activity, sleep, and stress in heart failure patients after they leave the hospital. The goal was to see if the device could capture useful data for at least 80% o…

This study aimed to develop a wearable system that could predict heart failure hospitalizations by collecting data from sensors. It planned to enroll up to 500 people but was terminated early with only 13 participants. The goal was to create an algorithm to detect worsening heart…

This study looked at how different pacing modes affect blood pressure in people with heart failure who have a special pacemaker called a CRT device. Researchers measured the highest blood pressure achieved with each mode to see which one works best. The study included 50 adults w…

This study looked at whether a wearable defibrillator (WCD) can accurately record heart sounds in people with heart failure. About 60 adults with heart failure and weak heart pumping (ejection fraction 40% or less) took part. The goal was to compare the WCD's recordings to a stan…