HEART FAILURE

This study tested whether adding a new drug called AZD5462 to standard treatment (dapagliflozin) could help people with both heart failure and moderate kidney disease. The goal was to see how the combination affected sodium excretion and other health markers. Only 8 participants …

This study tested a single dose of an experimental drug called REGN5381 in 89 people with chronic heart failure whose hearts pump less blood than normal. The goal was to check safety, side effects, and how the drug affects heart stress markers. The study was terminated early, so …

This study tested a new medicine called XXB750 in 136 people with heart failure and reduced heart pumping ability. The goal was to see if the drug could lower a key stress marker in the blood and improve symptoms. The trial was stopped early, but the results help researchers unde…

This study tested a small heart pump called the HeartWare MVAD in 11 people with severe heart failure. The goal was to see if the device is safe and helps patients live longer. The trial was stopped early, but it measured how many patients survived for 6 months and 2 years.

This study tested an experimental drug called LY3540378 in adults with worsening chronic heart failure where the heart pumps normally but doesn't fill properly (HFpEF). The goal was to see if the drug could improve heart function and safety. About 332 people were planned to join,…

This study tested whether a medicine called Ponsegromab could improve symptoms and quality of life in adults with heart failure. Participants received either the drug or a placebo as a shot every four weeks for about 9 months. The trial was stopped early, so results are limited. …

This study tested whether letting heart surgery patients manage their own recovery (self-managed sternal precautions) leads to better quality of life than following standard strict precautions. Researchers enrolled 10 adults who had chest-opening heart surgery and tracked pain, r…

This study looked at how well a wearable defibrillator (WCD) records heart sounds compared to a standard device. It involved 60 adults with heart failure and weak heart pumping. The goal was to see if the WCD's recordings are accurate enough for monitoring.

This study tested a special wearable patch that tracks health signals in people with heart failure. The goal was to see if the patch could warn doctors before a patient needs to go to the hospital. About 13 adults who had recently been hospitalized for heart failure took part. Th…

This study looked at people with heart failure who had a special pacemaker (CRT) implanted. The goal was to see which of three pacing modes gave the best immediate boost in blood pressure. The study was stopped early, but it aimed to help doctors choose the best settings for each…