HEART FAILURE

This study tested an experimental drug called REGN5381 in people with chronic heart failure where the heart pumps less effectively. The goal was to check the drug's safety, how it behaves in the body, and its effects on a key heart stress marker. Participants received a single do…

This study tested a small mechanical pump called the MVAD system, which helps the heart pump blood in people with very severe, advanced heart failure. The main goal was to see if the device was safe and helped patients survive for at least six months. Researchers also tracked com…

This early-stage study aimed to test the safety and effects of an experimental drug called AZD5462 when added to a standard heart failure medication (dapagliflozin). It involved a small group of people who had both heart failure and moderate kidney impairment. The study was termi…

This study tested whether an experimental drug called LY3540378 could help adults with a specific type of worsening heart failure where the heart pumps normally but doesn't relax properly. The trial enrolled 332 participants who had recently been hospitalized or needed urgent tre…

This study aimed to test if a new injectable drug called XXB750 could help control heart failure. It was compared against a placebo (dummy treatment) and an existing pill. The trial was stopped early because more patients getting the new drug experienced worsening heart failure, …

This study compared two approaches to recovery after open-heart surgery. One group followed strict movement restrictions (like not lifting over 5-8 pounds). The other group was told to let their pain and discomfort guide their activity. Researchers wanted to see if the more flexi…

This study tested whether a new injectable medicine called Ponsegromab could improve symptoms, physical function, and quality of life for adults with heart failure. About 455 participants received either the study medicine or a placebo injection every four weeks for about nine mo…

This study tested how accurately a wearable defibrillator vest could measure heart sounds compared to a standard medical device. It involved 60 adults with heart failure and weakened heart function. The goal was to see if the wearable device could reliably capture these sound mea…