HEART FAILURE

This study tests whether adding extra pacing from a heart device can improve heart function in people with heart failure and a specific electrical problem (left bundle branch block). Eighty adults who already qualify for a special pacemaker-defibrillator will try two pacing metho…

This study looks at whether reducing the number of kidney function tests during heart failure treatment helps patients reach higher, more effective medication doses without safety risks. It involves 344 adults with heart failure and reduced pumping ability. Researchers will compa…

This study tests a new approach for people with end-stage heart failure and a fast, irregular heartbeat (atrial fibrillation). Participants will get a special pacemaker and a small procedure to control the heart's rhythm, plus an implantable defibrillator (ICD). The goal is to se…

This study tests if dapagliflozin, a drug used for diabetes, can improve exercise ability and heart function in people who had the Fontan procedure (a surgery for a single-ventricle heart defect). About 30 adolescents and adults will take the drug daily for 3 months. The main goa…

This study tests whether a mouthpiece worn during sleep can improve heart health and quality of life in people with both heart failure and obstructive sleep apnea. The device, called a mandibular advancement device (MAD), keeps the airway open. 328 adults in Singapore will use ei…

This study tests whether a small, wireless heart monitor called CardioMEMS can help people with a mechanical heart pump (LVAD) avoid hospital stays for heart failure. About 40 adults who already have an LVAD will be randomly assigned to either get the monitor or receive standard …

This study tests whether providing home-delivered meals and extra dietary advice helps older veterans with heart failure stay out of the hospital and feel better. About 1,400 veterans aged 60 and older will be randomly assigned to receive either the meal support plus standard car…

This study compares a newer pacing method (directly pacing the heart's natural electrical system) to the standard pacing method in 1100 people with heart failure and a specific heart block. The goal is to see if the new method reduces the chance of death or unplanned hospital vis…

This study tests whether the drug finerenone can improve heart structure and function in 156 adults with an enlarged left side of the heart and risk factors for heart and kidney disease. Participants will take either finerenone or a placebo daily for 12 months and undergo heart s…

This study tests a procedure called renal denervation (RDN) that uses radiofrequency energy to calm certain nerves in the kidneys. The goal is to see if it can lower a key heart failure marker (NT-proBNP) and improve exercise ability in 20 adults with heart failure. Participants …

This study tests whether quickly starting and increasing heart failure medications in women after a hospital stay can lower the risk of death or another hospital visit within a year. About 360 women from 13 hospitals in Italy will be randomly assigned to either an intensive medic…

This early-stage study tests whether a second infusion of a patient's own modified immune cells (CAR-DC) can safely improve heart function in people with end-stage dilated cardiomyopathy, a condition where the heart is enlarged and weak. The cells target a protein called FAP to c…

This study tests whether a heart pump (Impella 5.5) combined with optimized heart failure medications can help people with severe heart failure and shock recover without needing a transplant or permanent heart assist device. About 250 adults aged 18-79 with a weak heart pump (LVE…

This study compares two blood thinners—apixaban and warfarin—in people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents serious problems like stroke, blood clots, and major bleeding. About 460 adults who have had the pum…

This study tests whether using remote blood pressure monitors and video doctor visits can help people with heart failure who live in rural areas better manage their condition. Researchers will enroll 32 participants to see if this approach is practical and acceptable. The goal is…

This study tests whether a newer drug, finerenone, is safer than an older drug, spironolactone, for people with heart failure and diabetic kidney disease who are at high risk for high potassium levels. About 60 participants will receive either finerenone daily or spironolactone e…

This study looks at whether switching heart failure patients in rural Tanzania from their current medication to a newer drug called sacubitril-valsartan can improve their daily health and ability to walk. About 298 adults with reduced heart function will be followed for 10 months…

This study tests whether a nurse-led education program can reduce hospital readmissions for patients undergoing hip or knee replacement who also have conditions like heart failure, COPD, or kidney problems. About 300 participants will either receive the extra nurse support or sta…

This study tests whether taking selenium and coenzyme Q10 (CoQ10) supplements can reduce heart failure-related hospital visits and deaths. About 1,100 adults with chronic heart failure will receive either the supplements or a placebo, alongside their usual care. The goal is to se…

This study compares a newer pacing method (left bundle branch area pacing) with the standard approach for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if the newer method improves the heart's pump…

This study will test the safety and performance of a new generation of implantable cardioverter-defibrillators (ICDs) called CorSky. These devices are for people with dangerous heart rhythms or heart failure. About 151 participants will get the device and be followed for 6 months…

This study tests a new medicine, NNC0487-0111, given as a weekly injection, in about 5,600 people who have both heart failure and obesity. The goal is to see if it can reduce the risk of death or hospitalization compared to a placebo. Participants will be randomly assigned to rec…

This study tests if a drug called sodium zirconium cyclosilicate can help people with heart failure stay on higher, more effective doses of a standard medication (MRA). The trial involves 110 participants in Sweden and lasts about 6 months. The goal is to see if this approach imp…

This study tests whether a national accreditation program for hospitals can improve care for people with heart failure in China. About 6,240 patients will be followed for 12 months after discharge. The goal is to see if accredited hospitals reduce hospital readmissions and deaths…

This study tests a device that uses focused ultrasound pulses from outside the body to soften hardened heart valves in people with severe aortic stenosis. About 200 participants who cannot or choose not to have standard valve replacement will be followed for 12 months to see if t…

This early-stage study tests a single injection of SHR-4658 in 48 healthy people and those with high blood pressure to see if it is safe and how the body handles it. The goal is to gather initial safety data for a potential heart failure treatment. Participants must be 18-55 and …

This study tests whether a digital support package (DEEPER) helps heart patients maintain health after completing cardiac rehab. About 306 adults with heart disease or heart failure will either get standard care or standard care plus the digital program. The main goal is to see i…

This study tests whether adding finerenone to standard heart failure treatment (an SGLT2 inhibitor) can reduce deaths and hospital stays. About 60 adults with newly diagnosed heart failure will receive either the combination or the standard drug alone. The goal is to see if the c…

This pilot study will test a new clinic that treats both heart failure and methamphetamine use disorder at the same time. About 50 adults with heart failure who use methamphetamine will receive heart medications, counseling, and rewards for staying drug-free over 6 months. The go…

This study tests whether AI-generated reminders can help doctors prescribe the right heart failure medications. About 500 adults with heart failure will have their doctors receive brief, computer-written suggestions before appointments. The goal is to see if this leads to better …

This study tests a telemedicine program for older adults (ages 65-80) with both atrial fibrillation and heart failure in rural China. Village doctors use a digital platform with remote expert support to guide medication and lifestyle changes, including group exercise and wearable…

This study looks at whether using lower doses of two blood thinners (argatroban and enoxaparin) can reduce bleeding and clotting problems in adults on ECMO, a machine that helps the heart and lungs. About 200 participants with pneumonia or heart failure will be enrolled. The goal…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs of people with heart failure. The treatment aims to reduce serious heart events like hospitalizations or death. About 750 adults with stable heart failure will be randomly assigned…

This early-phase study tests a new treatment for people with severe heart failure. Doctors will inject lab-grown heart muscle cells (made from iPS cells) directly into the heart to try to repair damaged tissue. The study involves 14 participants and will check safety and whether …

This study tests whether people with acute heart failure can be sent home early and receive a diuretic injection under the skin instead of staying in the hospital for IV treatment. About 250 adults will be randomly assigned to either early discharge with the injection or standard…

This study tests a new sensor system (FIRE1 NORM) that is implanted in the body to monitor fluid levels in people with heart failure. The goal is to see if using this sensor to guide treatment can reduce the number of hospital visits and deaths compared to standard care. The stud…

This study tests whether adding Relaxin, a natural hormone, to standard care can lower the amount of atrial fibrillation (AF) in 208 Veterans who still have symptoms despite medication and are scheduled for a heart ablation procedure. The goal is to see if Relaxin reduces oxidati…

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (an irregular heartbeat) in people with heart failure who need a pacemaker or defibrillator. About 110 participants will be randomly assigned to receive either the n…

This study compares remote monitoring using the HeartLogic algorithm against standard in-person checkups for 578 adults with heart failure who have a special defibrillator. The goal is to see if remote alerts can reduce deaths, unplanned hospital stays, and declines in quality of…

This study tests whether adding L-arginine, a natural amino acid, to standard heart failure treatment can improve heart function and symptoms. About 200 adults with a weak heart pump (ejection fraction below 40%) will take L-arginine or a placebo for a period. The goal is to see …

This study tests whether the drug finerenone can slow kidney function decline and lower the risk of heart failure in 120 adults with diabetic kidney disease. Participants must have type 2 diabetes and chronic kidney disease, and be on stable blood pressure medication. The study w…

This study will test several different treatments for heart failure at the same time to see which ones work best. About 1000 adults with heart failure will take part. The main goal is to reduce deaths and hospital stays due to heart problems.

This study will test whether using a real-time continuous glucose monitor (CGM) helps manage blood sugar better than standard finger-stick testing in people with type 2 diabetes who are hospitalized for heart failure. Researchers will follow 140 adults for 3 months after discharg…

This study tests a new imaging agent called 18F-mFBG to see how well it can show nerve damage in the hearts of people with heart failure and an implantable defibrillator (ICD). About 20 adults with stable heart failure will get a PET scan after receiving the agent. Researchers wi…

This study will test a quick finger-prick blood test that gives results in 12 minutes to screen for hidden heart failure in people with leg swelling (lymphedema). About 618 adults attending lymphedema clinics will be offered the test. If the test is positive, they will be referre…

This study tests if a non-invasive liver scan (FibroScan) can accurately detect elevated central venous pressure in people with heart failure. Currently, doctors use a catheter inserted into the heart, which carries risks. The study will enroll 149 adults with suspected or confir…

This study tests whether a tool called FIND HF can spot people at high risk for undiagnosed heart failure. About 475 adults aged 40 and older will have a blood test and an ultrasound of their heart. Researchers will compare how often heart problems are found in high-risk versus l…

This study tests a new way to measure kidney function in 15 adults with heart failure using a skin sensor and a fluorescent dye injection. The goal is to see if the sensor can accurately track kidney function compared to standard blood tests. Participants wear a sensor on their c…

This study aims to see if a single-lead electrocardiogram (ECG) analyzed by machine learning can accurately screen for heart conditions and related diseases like high blood pressure, diabetes, and kidney disease. Researchers will enroll at least 5,000 adults who have already had …

This study tests if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in adults with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echos) from 150 participants. The AI's findings will be checked against …

This study tests whether a telemedicine program led by village doctors can prevent heart failure in older adults (ages 65-80) in rural China who have atrial fibrillation but not yet heart failure. Participants use wearable devices, get lifestyle coaching, and receive remote speci…

This study tests whether a mobile app can help people with heart failure take better care of themselves after leaving the hospital. Thirty participants will use the app alongside their usual care to learn about their condition, track symptoms, and communicate with their healthcar…

This study tests a personalized system that uses smart wristbands and a mobile app to help heart failure patients increase physical activity and sit less. The system sets custom activity goals based on each person's heart data and provides real-time feedback and motivation. About…

This early-stage study tests a single dose of the experimental drug LY3971297 in 90 people with heart failure (either with preserved or reduced pumping ability). The main goal is to check for side effects and how the body handles the drug. Participants will be monitored for about…

This study tests a 10-session program called ViCCY for informal caregivers (spouses or children) of older adults with heart failure and mild to moderate memory problems who are receiving home health care. The goal is to reduce caregiver stress and improve their mental health. Abo…

This study tests whether adding sauna therapy to standard cardiac rehabilitation can reduce fluid buildup (congestion) in people with heart failure. About 46 adults with reduced heart function will be randomly assigned to either a standard rehab program or one that includes sauna…

This study will compare two types of exercise training—neuromuscular and resistance training—in 40 adults with chronic heart failure. Participants will do supervised exercises for 10 weeks. The goal is to see which approach better improves walking ability, heart fitness, and leg …

This study tests whether combining breathing exercises with a simple mental task can improve memory, attention, and thinking in adults with heart failure. Fifty-four participants will be split into three groups: dual-task breathing training, standard breathing training, or usual …

This study tests a new support program for family carers of people with heart failure in the UK. Around 180 carers will receive six weekly online sessions, a booklet, and a website to help them care for themselves and their loved one. The goal is to see if this program reduces ca…

This study tests whether a 7-day course of intravenous steroids can reduce harmful inflammation and help 30 adults recover from heart failure-related cardiogenic shock. Participants must have high inflammation levels and be in the ICU. The goal is to see if the treatment is safe …

This study tests a custom exercise program for people over 65 with heart failure. The program starts in the hospital and continues at home. Researchers want to see if it helps patients walk better, feel stronger, and improve their quality of life. About 114 participants will take…

This study tests a new way to place a pacing lead in the heart to help people with heart failure. The method uses a special catheter to map the heart's electrical signals and guide the lead to a specific area called the Bachmann bundle. The goal is to see if this approach is safe…

This study will follow 110 patients aged 80 and older who are hospitalized for acute heart failure. Researchers will use muscle ultrasound, strength tests, and blood markers to understand how muscle loss (sarcopenia) affects their recovery. The goal is to find better ways to pred…

This study tests a new computer tool that helps doctors decide when to refer heart failure patients to palliative care. The tool uses a risk score to predict who might benefit from extra support. Researchers will see if doctors find the tool easy to use and if it leads to more ti…

This study will monitor 150 adults with type 2 diabetes, some with heart failure or kidney disease, to see how a class of drugs called SGLT2 inhibitors affects the balance between the 'fight or flight' and 'rest and digest' nervous systems. Participants will wear a heart monitor …

This study observes 30 adults in Mexico who are already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans, heart CT scans, and body composition tests to see how the drug affects knee cartilage, heart fat, and overall body health over one y…

This study looks at 200 adults with a type of heart failure called HFpEF to see if they can be grouped into different categories based on their medical information. Researchers want to know if these groups have different health profiles and respond differently during an exercise …

This study looks at whether making a small opening between the upper heart chambers during mitral valve surgery can prevent heart failure symptoms after the operation. It will enroll 50 adults with severe mitral regurgitation who are already scheduled for surgery. Half will get t…

This study aims to find out how common diastolic dysfunction (a type of heart failure) is in people with end-stage kidney disease who are on regular hemodialysis. Researchers will use echocardiograms to check heart function and look for links with dialysis-related factors. The st…

This early-stage study tests whether showing heart failure patients easy-to-understand graphics about how their medications improve survival can help them stick to their treatment plan. About 100 adults with reduced ejection fraction will receive these visual aids and have their …

This study looks at whether reminding doctors about iron deficiency in hospitalized heart failure patients leads to more use of IV iron. About 3,000 adults with heart failure and low iron will be included. Doctors in one group get a notification with test results and treatment gu…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and remote monitoring to understand why some patients respond well to treatment while others do not. The goal is to id…

This study looks at whether a remote monitoring system (called RAPHAEL) can work for adults with heart failure who may need palliative care. About 90 patients will answer digital questionnaires about their symptoms and needs over 4 weeks. Doctors will review the responses and fol…

This early-stage study tests the safety and tolerability of a new drug called HRS-5765 in 74 healthy adults aged 18-65. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and how the drug moves through the body. This study does n…

This study will follow about 1,000 people who receive a BIOTRONIK pacemaker or defibrillator for conditions like slow heartbeat, fast heartbeat, or heart failure. The goal is to see how well the devices work and how safe they are during normal, everyday use. Researchers will chec…

This study will test a new type of heart MRI that can see tiny details in heart muscle, like early damage or healing. Researchers will compare these images with standard tests in 1000 adults with and without heart disease. The goal is to learn which markers are best for spotting …

This study looks at 130 adults with heart failure who were part of a telemonitoring program but later left it because they no longer met eligibility rules. Researchers will track them for one year to see if they have serious heart events or need emergency care. The goal is to und…

This study looks at how well doctors follow recommended treatments for advanced heart failure. Researchers will track 300 patients to see if they receive the four key medications. The goal is to understand current care and measure patients' quality of life.

This study will review the medical records of 200 adults with heart failure, moderate-to-severe chronic kidney disease, and anemia who took roxadustat for at least a year. Researchers want to see if the drug improved heart function and reduced serious heart events. This is an obs…

This study looks at whether low iron levels (with or without anemia) raise the risk of heart rhythm problems in people hospitalized for heart failure. Researchers will check 300 adults for iron deficiency and monitor their heart activity using ECGs. The goal is to find simple way…

This study aims to better understand heart failure by looking at patients' genes, proteins, and other molecules. Researchers will enroll 500 adults with heart failure and collect detailed health data and blood samples. The goal is to find patterns that predict disease progression…

This study aims to see if a personalized approach, called N-of-1 trials, can help older adults with heart failure find the highest beta-blocker dose they can tolerate without side effects. Fifty participants aged 60 and older will be split into two groups: one using the personali…

This study will track 3,000 adults in China with a type of heart failure called HFpEF who are starting the drug Jardiance. Researchers want to see how well the drug works and if it causes any side effects in everyday use, not in a controlled lab setting. The goal is to learn more…

This study aims to understand how inflammation and genetic factors influence the health of people hospitalized with heart failure. Researchers will analyze blood samples from 112 participants to find markers that may predict future heart problems. The study is observational, mean…

This study looks at whether certain blood markers can predict delirium (sudden confusion) in older adults with heart failure. Researchers will measure inflammation and metabolism-related markers in 100 participants and track who develops delirium. The goal is to find a simple way…

This study will check how well heart failure and atrial fibrillation patients take their prescribed medications after being admitted to the coronary care unit. Researchers will use questionnaires to understand patients' beliefs about their medicines and whether their prescription…

This study is for people with heart failure who need a right heart catheterization. Researchers are collecting data to train a machine learning model for a non-invasive device that estimates heart pressure. The goal is to help doctors better manage heart failure without invasive …

This study will use artificial intelligence and 3D ultrasound to measure how well the heart's right chambers work together in healthy adults and people with heart conditions. Researchers aim to set a normal range for this measurement and see if it can help diagnose or predict pro…

This study tests whether a smartwatch with artificial intelligence can help doctors monitor heart attack patients after they leave the hospital. About 200 adults who had a heart attack and a stent placed will wear a smartwatch for 3 months. The goal is to see if the AI can predic…

This study looks at whether a hybrid care model—using tools like telemonitoring, video visits, and online prescriptions—can help keep regular care going for people with type 2 diabetes and heart failure during health emergencies. About 180 participants will be observed and interv…

This study will test three heart failure risk models (MAGGIC, GWTG-HF, and SHFM) in 140 Egyptian patients to see how well they predict death and hospital readmission. These models were created using mostly Western patients, so they may not be accurate for Egyptians, who tend to b…

This study looks at whether an Apple Watch can help predict when heart failure might get worse. Researchers will collect fitness and health data from the watch and combine it with medical tests. The goal is to see if this approach works as well as the standard exercise test. Abou…

This study will follow 3,000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or other metabolic problems. Researchers will track health outcomes over two years to better understand these connections. The goal is to improve …

This study will follow 2000 adults hospitalized with heart failure in Brazil to understand how they are treated and what happens to them over a year. Researchers want to see if doctors are using the latest recommended medicines and find any barriers to giving the best care. The g…

This study is testing a new computer-based decision aid designed to help cancer survivors and their heart doctors. The tool, accessed through electronic health records, aims to improve decisions about heart-protective medications and monitoring tests. Researchers want to see if b…