HEART FAILURE

This large study is a flexible testing platform designed to find better ways to manage heart failure. It will enroll 1,000 adults who are either hospitalized for worsening heart failure or are stable outpatients. The platform will test multiple treatments at once, aiming to reduc…

This study is testing a new national program in China designed to improve the quality of care for people hospitalized with heart failure. It will compare hospitals using the new accreditation system against those giving usual care. The goal is to see if the program leads to bette…

This study is testing a new technology system to help people with heart failure be more physically active. It uses a smart wristband and a phone app to create personalized daily activity goals based on the user's own heart rate. The system gives real-time feedback and rewards to …

This study is testing whether adding the drug finerenone to standard heart failure care can improve the heart's structure and function in people at risk for heart and kidney problems. About 156 participants with a thickened heart muscle will take either finerenone or a placebo pi…

This study tests whether using a wireless heart monitor (CardioMEMS) helps reduce hospital visits for people with advanced heart failure who use an LVAD pump. Researchers will compare 40 patients using the monitor against those receiving standard care to see if it leads to fewer …

This study is testing if it's safe and effective to send patients hospitalized for worsening heart failure home early. Instead of staying in the hospital for several days to receive standard IV diuretics, participants would go home and self-administer a similar medication as a si…

This study aims to see how well the medication Jardiance works and how safe it is for people in China with a common type of heart failure (HFpEF) in real-world hospital settings. It will follow 3,000 adult patients who are newly starting Jardiance to track their health outcomes. …

This study is testing whether a smartwatch that uses artificial intelligence (AI) can help people recover better after a heart attack. 200 patients will wear a smartwatch for 3 months after leaving the hospital. The goal is to see if the AI's analysis of the watch's data can help…

This study tests whether a telemedicine support program helps village doctors better manage older adults with both atrial fibrillation and heart failure in rural China. About 1,200 participants will receive either the digital program with medication guidance, remote expert suppor…

This small pilot study is testing whether adding a short course of steroid medication to standard hospital care can help patients with severe heart failure shock. The condition causes poor blood flow and triggers harmful inflammation, even when using heart pumps. Researchers will…

This study is testing whether providing home-delivered meals and extra dietary counseling to older veterans after a heart failure hospitalization helps them recover better. It will compare this support to standard dietary advice alone. The main goal is to see if the meals help pe…

This study is testing whether injecting lab-grown heart muscle cells directly into the heart during bypass surgery can help people with severe heart failure. About 80 participants will be randomly assigned to receive either standard surgery alone or surgery plus the stem cell inj…

This is a small pilot study to test a new smartphone app designed to help people with heart failure take better care of themselves after they leave the hospital. The app provides education, tracks symptoms, and connects patients with their care team. Researchers will see if the a…

This large study is testing whether adding a small implanted device called Barostim helps people with moderate heart failure live longer and stay out of the hospital. It will compare the device plus usual medications against medications alone in 2500 participants over two years. …

This study is testing whether using a continuous glucose monitor (a small sensor that tracks blood sugar levels every few minutes) can help people who have both type 2 diabetes and heart failure. Researchers want to see if better, real-time sugar monitoring during and after a hos…

This study will test if the medication finerenone can slow the worsening of kidney function and lower the risk of heart failure in adults with diabetic kidney disease. It will involve 120 participants who have type 2 diabetes and early to moderate kidney problems. The goal is to …

This study aims to see if sending doctors guideline reminders about iron deficiency treatment changes how often they give IV iron to hospitalized heart failure patients. It will compare outcomes between hospitals where doctors receive these reminders and hospitals where they don'…

This study is testing if a drug called dapagliflozin can help people who have had a Fontan heart surgery. It aims to see if the drug improves their ability to exercise and their heart function over three months. The trial will involve about 30 adolescents and adults in Hong Kong …

This study is testing if a mouthpiece worn during sleep can help people who have both heart failure and a common sleep disorder called obstructive sleep apnea. The mouthpiece is designed to keep the airway open, which may reduce stress on the heart and improve symptoms. Over 300 …

This study aims to see if doctors can safely check kidney function less often while increasing heart failure medications to their best doses. It will involve 344 adults with a specific type of heart failure who are not yet on the full recommended doses of their key medicines. The…

This study aims to see if taking selenium and coenzyme Q10 (CoQ10) supplements can help people with chronic heart failure. It will compare these supplements against a placebo (inactive pill) in 1,100 adults to see if they reduce hospital visits and deaths related to heart problem…

This study aims to see if starting women on full-strength heart failure medications quickly after a hospital stay, and monitoring them closely, works better than the usual slower approach. It will follow about 360 women in Italy for a year to see if the faster plan leads to fewer…

This study is testing a new digital alert system for people with heart failure who have a special implanted heart device. The system analyzes data from the device and sends alerts to the healthcare team, aiming to spot problems early and adjust treatment. Researchers want to see …

This study will compare two different ways to pace the heart in people with heart failure and abnormal electrical signals. About 1,100 patients will be randomly assigned to receive either the standard biventricular pacing or a newer method that tries to pace the heart's natural w…

This study is testing if using a temporary heart pump (Impella 5.5) can help stabilize patients in severe heart failure shock so doctors can safely start and adjust the best recommended medications. The goal is to see if this combination helps the heart recover strength. About 60…

This study tests whether personalized medicine trials can help older adults with heart failure find their highest tolerated beta-blocker dose. Fifty participants will either try a personalized approach where they test different doses while tracking how they feel, or receive stand…

This study is testing a medical device designed to lower dangerously high blood pressure in the lungs of people with heart failure. Researchers will compare the device procedure to a placebo procedure in 750 participants who are already on the best available heart medications. Th…

This study is testing if checking the salt level in a patient's urine can help doctors better adjust their 'water pill' (diuretic) dose. Researchers want to see if aiming for a higher urine salt target helps patients get rid of more fluid, recover faster, and avoid being readmitt…

This study compares two common heart procedures—bypass surgery (CABG) and stent placement (PCI)—for people with weakened heart pumps and multiple clogged arteries. Researchers will follow 358 patients for 4 years to see which approach leads to better survival, fewer heart problem…

This is an early safety study testing a new experimental drug called SHR-4658 for heart failure. Researchers will give single injections to 48 healthy volunteers and people with elevated blood pressure to check for side effects and see how the drug moves through the body. The mai…

This study is testing whether adding a special pacing technique and a minor ablation procedure to a standard heart defibrillator implant can improve outcomes for people with very severe heart failure and a permanent irregular heartbeat (atrial fibrillation). The participants are …

This study is testing whether adding the amino acid L-Arginine to standard heart failure treatment can improve heart function and reduce symptoms. It will involve 200 adults with weakened heart pumping ability. Researchers will measure changes in heart strain, exercise ability, b…

This study aims to see if adding a medication called finerenone to standard heart failure treatment provides extra benefits. Researchers will compare outcomes in 60 heart failure patients who receive the standard treatment alone versus those who receive the standard treatment plu…

This study aims to confirm the safety and performance of a new generation of implantable heart devices. It will enroll 151 adults who need a defibrillator or a special pacemaker to control dangerous heart rhythms or manage heart failure. The main goal is to see how well the new d…

This study is testing whether remote care using home blood pressure monitors and video consultations can help people with heart failure who live in rural areas manage their condition better. Researchers will work with 32 participants to see if this approach is practical and accep…

This study is testing whether a personalized heart rehabilitation program can help seniors with heart failure feel better and become more active. The program starts with gentle exercises in the hospital and continues with twice-weekly sessions for three months after going home. R…

This study aims to compare how two different drugs, vicadrostat and spironolactone, affect kidney function and proteins in the blood and urine of people who have both chronic kidney disease and heart disease or heart failure. About 100 participants will take one of the drugs alon…

This study is testing whether messages generated by an artificial intelligence (AI) tool can help heart doctors better follow established treatment guidelines for their patients. The AI will review a patient's medical records and send a brief, private message to their cardiologis…

This study is testing a new computer-based decision tool designed to help doctors better protect cancer survivors from heart problems. The tool will be tested with 60 cancer survivors who are at risk for heart disease. Researchers want to see if the tool is easy for doctors and p…

This study looks back at medical records to see if a drug called roxadustat, used to treat anemia in kidney disease, might also help people who have heart failure. Researchers will check if patients who took the drug for over a year had fewer major heart problems or improvements …

This study is testing a new type of clinic that treats heart failure and methamphetamine addiction together. It will enroll 50 people with both conditions to see if combining heart care with addiction counseling and incentives can help them stop using meth and better manage their…

This study is testing whether adding a digital support package to usual care helps people maintain their heart health after completing a cardiac rehabilitation program. It will involve about 306 adults who have had a heart attack or heart failure. Participants will be randomly as…

This study is testing whether adding a natural hormone called Relaxin to standard treatment helps control atrial fibrillation, a common irregular heartbeat condition. Researchers will give Relaxin to 208 veterans who haven't responded to medications and are scheduled for a heart …

This early-stage study is testing whether transplanting tiny spheres of lab-grown heart muscle cells can help people with severe heart failure. Fourteen patients will receive the cells via a catheter to their heart and be monitored for safety and potential improvements in heart f…

This study is testing a new, non-invasive way to check how well the kidneys are working in people with heart failure. Researchers want to see if a special sensor patch placed on the chest can measure kidney function as accurately as the standard blood test. Fifteen participants w…

This study is testing whether artificial intelligence (AI) can help doctors find a rare heart condition called ATTR amyloidosis earlier. It will check if AI can spot signs of the disease in standard heart tests (ECGs and echocardiograms) from 150 adults with heart failure. The go…

This study aims to develop a new screening tool for heart and related diseases. Researchers will use a smartphone-compatible device to record a simple, 1-minute heart rhythm reading from 5,000 participants. They will then use artificial intelligence to see if patterns in this rea…

This study is testing a new AI tool designed to spot people at high risk of having undiagnosed heart failure. About 475 participants, identified from their medical records as being at risk, will have a simple blood test and a heart scan. Researchers want to see if the AI tool cor…

This study is testing whether a quick, non-invasive liver scan can accurately detect high pressure in the heart. It aims to provide a safer alternative to the current invasive catheter procedure, which carries risks like bleeding and infection. The study will enroll 149 adults wi…

This study is testing a new non-invasive device that uses sensors and computer learning to estimate pressure inside the heart. It aims to help doctors monitor heart failure without needing invasive catheter procedures. The study will collect data from 392 patients who are already…

This study aims to prevent heart failure in older adults (65-80 years) in rural China who have atrial fibrillation but do not yet have heart failure. It will test whether a telemedicine program led by local village doctors—using wearable devices, lifestyle coaching, and remote sp…

This study is testing if performing a preventive heart procedure (called VT ablation) soon after implanting a defibrillator can reduce dangerous, fast heartbeats in high-risk patients with heart failure. About 62 participants will be randomly assigned to either get the preventive…

This study is testing if a special nurse-led education and support program can help high-risk patients avoid being readmitted to the hospital after hip or knee replacement surgery. It will involve 300 patients who have conditions like heart failure, COPD, or are on dialysis. The …

This study tests a virtual coaching program called ViCCY designed to help caregivers of adults with heart failure and memory problems. Caregivers will receive 10 coaching sessions over 6 months to learn self-care strategies and reduce stress. The research aims to see if supportin…

This study is testing a 6-week online support program called HELP for family members who care for people with heart failure. The program provides educational sessions and resources to help carers manage their own wellbeing while supporting their loved one. Researchers will measur…

This study is testing if adding regular sauna sessions to standard cardiac rehabilitation helps reduce dangerous fluid buildup in people with heart failure. Researchers will compare two groups of about 46 patients: one gets standard rehab, and the other gets rehab plus sauna ther…

This study is testing a new computer tool for doctors. The tool is designed to help identify hospitalized heart failure patients who might benefit from palliative care—a type of medical care focused on relieving symptoms and stress. The goal is to see if this tool makes it easier…

This early-stage study is testing whether taking an oral L-Carnitine supplement can help people with heart failure feel better. Researchers want to see if this naturally occurring substance, which helps the body turn fat into energy, can improve symptoms, heart function, and qual…

This study aims to understand if having low iron levels, with or without anemia, increases the risk of irregular heartbeats (arrhythmias) in people hospitalized for heart failure. Researchers will enroll 300 adult patients and compare their iron status with their heart rhythm dat…

This study aims to find blood markers that can predict which older adults with heart failure might develop delirium (sudden confusion) during hospital stays. Researchers will test 100 participants to see if certain inflammation and metabolism markers in the blood can identify hig…

This study aims to learn if certain markers of inflammation in the blood, along with genetic information, can help doctors predict which heart failure patients are at higher risk for future health problems. Researchers will collect blood samples from 112 hospitalized patients wit…

This study aims to understand why some patients with heart rhythm problems respond well to treatments like pacemakers or ablation, while others do not. Researchers will observe 253 adults with various heart conditions who are scheduled for these procedures. By using advanced hear…

This study aims to understand how seasonal changes affect physical activity levels in people with heart failure who have implanted heart devices. Researchers will observe 24 patients over a year, tracking their movement with wrist-worn activity monitors and questionnaires. The go…

This study aims to group people with a common type of heart failure (HFpEF) based on their symptoms and test results to see if different groups exist. Researchers will analyze medical records of 200 patients and have a smaller group perform an exercise test. The goal is to learn …

This study is testing whether a remote monitoring system can help identify when heart failure patients might benefit from comfort-focused (palliative) care. About 90 adults with worsening symptoms will answer a digital questionnaire about their needs over 4 weeks. The goal is to …

This study aims to understand how often heart failure occurs alongside other conditions like kidney disease, diabetes, and fatty liver disease, and how these combinations affect patient health over time. It will follow 3,000 adults in Russia with or at risk for heart failure for …

This study looks back at patients who were in a remote heart failure monitoring program but were later taken off it because they no longer met the official criteria. Researchers want to see if these patients truly have a low risk of their heart condition getting worse after stopp…

This study aims to see if a new 'hybrid' care model is practical for patients during major health emergencies like pandemics. It will involve 180 people with type 2 diabetes or heart failure who also have other chronic conditions. The model combines digital tools like remote moni…

This study is testing a new imaging agent called 18F-mFBG to see if it can create better pictures of nerve activity in the heart. It will involve 20 stable patients who have heart failure and an implanted defibrillator. The goal is to learn if this new scan can help identify pati…

This study aims to test and validate new, faster heart MRI scanning techniques that can detect very early tissue damage. Researchers will compare these detailed heart images with standard blood tests in 1,000 participants, including both people with various heart conditions and h…

This study aims to deeply understand heart failure by analyzing the molecular details of 500 patients. Researchers will combine detailed health information with advanced lab tests on blood and tissue samples to find patterns linked to the disease. The goal is to discover clues th…

This study aims to understand how a common diabetes medication (SGLT2 inhibitors) affects the body's automatic nervous system, which controls the heart. Researchers will monitor the heart rate patterns of 150 adults with type 2 diabetes, some of whom also have heart failure or ch…

This study aims to define the normal, healthy range for a new measurement of how the heart's right chambers work together, using AI-powered 3D ultrasound scans. It will enroll 2,640 healthy adults and people with specific heart and lung conditions to see how this measurement chan…

This study is a registry that will follow 1,000 patients who have received specific BIOTRONIK heart pacing devices. The goal is to collect long-term, real-world information on how well the devices work and their safety. It does not test a new treatment but observes patients alrea…

This study aims to find out if data from an Apple Watch, combined with basic health information, can predict when a person's heart failure is getting worse. Researchers will follow 360 adults with heart failure to see if the watch data can provide early warnings about declining f…

This study aims to understand how common and how serious a specific type of heart problem is in people with end-stage kidney disease who receive regular dialysis. It will involve 100 adult patients and will use heart ultrasound scans to look for issues with how the heart relaxes …

This study aims to check if three existing heart failure risk calculators, developed mainly in Western countries, work accurately for patients in Egypt. Researchers will follow 140 Egyptian heart failure patients for one year to see how well these calculators predict death and ho…