HEART FAILURE

This study tested whether a blood pressure/heart rate medication called nebivolol could prevent heart muscle weakness in boys with Duchenne muscular dystrophy. Fifty-one boys aged 10-15 with Duchenne but normal heart function at the start took either nebivolol or a placebo pill d…

This study tested whether a digital health program helps people with heart failure recover better after leaving the hospital. The program used smartphone apps for education, self-monitoring, and remote check-ins with a special vest sensor. Researchers wanted to see if this approa…

This study aimed to find the best way to protect the right side of the heart after patients with heart failure get a mechanical pump (LVAD) implanted on the left side. It compared two different post-surgery care plans in 20 patients to see which one better prevented weakness in t…

This study tested a new feature for heart failure pacemakers called AutoAdapt. It automatically and continuously adjusts the device's timing to try to improve heart function. Researchers compared this automatic adjustment to the standard method where doctors manually optimize the…

This study tested whether using a remote monitoring system could help manage heart failure and reduce hospital visits. 330 adults with chronic heart failure used a home monitoring device that tracked heart pressure and other measurements, with doctors adjusting medications based …

This study tested a web application designed to help people with a specific type of heart failure (HFrEF) get the best possible medications. 225 participants were randomly assigned to either use the 'SmartHF' app or receive usual care for 12 weeks. The app analyzed patients' heal…

This study tested whether a more comprehensive remote monitoring system could help heart failure patients with special pacemakers stay healthier and avoid hospital visits. Researchers compared two different remote monitoring approaches over 27 months to see which was better at pr…

This study tested a new support program for people with heart failure after they leave the hospital. A nurse-led team used a smartphone app to help 104 patients track their weight, symptoms, and medications at home. The goal was to see if this extra digital support, compared to s…

This study tested whether the heart failure drug vericiguat improves the health of patients' blood vessels and reduces body-wide inflammation. It involved 26 adults with chronic heart failure who were already on standard treatments. Researchers measured blood vessel function, wal…

This trial tested whether a small implanted device called Barostim could help people with moderate-to-severe heart failure. The device sends gentle electrical pulses to a neck artery to calm an overactive nervous system, which can worsen heart failure. About 1,090 participants we…

This study tested a special heart pacing method called His Bundle pacing in heart failure patients with left bundle branch block. Researchers mapped the heart's electrical system during device implantation to find the best pacing locations that improve the heart's coordination. T…

This small pilot study tested whether trained community health workers could help heart failure patients in rural Haiti stick to their care plans after leaving the hospital. The workers visited patients at home and called them to provide education, remind them of appointments, an…

This study tested whether doing cardiac rehabilitation at home using a mobile app works as well as traditional clinic visits. Researchers compared three approaches: clinic-only rehab, clinic plus app support, and app-only remote rehab. They measured heart health, fitness, and hos…

This study tested a coordinated care program for older adults with heart failure after a hospital stay. It combined home monitoring of weight and symptoms with nurse education and clinic check-ups. The goal was to catch problems early and reduce the need for patients to return to…

This study tested if sending patients with heart failure and an implanted defibrillator to a specialized clinic run by a nurse practitioner leads to better health than standard care. The goal was to see if this extra support helps patients take their heart medications more consis…

This study tested two different exercise programs for people with heart failure to see which is better at improving fitness, reducing muscle loss, and easing symptoms like shortness of breath. Twenty-two participants completed either a steady-paced or an interval-based workout pl…

This study compared two heart failure medicines in people whose heart damage was caused by Chagas disease. It tested if a newer drug (sacubitril/valsartan) was better than a standard one (enalapril) at preventing hospital stays and death from heart problems. The goal was to find …

This study tested if giving a heart medication called carvedilol to breast cancer patients at higher risk of heart damage could protect their hearts during chemotherapy. It involved 68 women receiving specific cancer drugs (doxorubicin and/or trastuzumab). The goal was to see if …

This study tested two ways to help heart failure patients recover at home after a hospital stay. One group got a follow-up phone call from a care coordinator. The other group had access to a community paramedic who could visit their home and connect them to a doctor by video. Res…

This completed Phase 2 trial tested whether the experimental drug tovinontrine could help control heart failure in patients whose hearts pump normally but still struggle. The study involved 303 adults with chronic heart failure symptoms who received either the drug or a placebo f…

This study tested if a drug called Henagliflozin could help people who just had a major heart attack. About 240 patients who had emergency heart surgery (PCI) took the drug or a placebo for 6 months. Researchers checked if the drug reduced the amount of permanent heart damage and…

This study aimed to see if a heart failure medication called sacubitril/valsartan works as well for African American patients as it does for others. Researchers followed over 6,500 African American patients with weakened heart pumping to compare outcomes between this drug and sta…

This hospital quality improvement project aimed to provide better, more equitable care for heart failure patients admitted to the general medicine service. It tested a structured support plan to ensure patients received proper medications, follow-up appointments with heart specia…

This study tested whether adding a once-daily diabetes medication (dapagliflozin or empagliflozin) to standard treatment could help non-diabetic patients who recently had a serious heart attack. The goal was to see if these drugs could reduce future hospitalizations for heart fai…

This study tested whether providing 12 weeks of healthy, pre-made meals designed for heart health could improve the diets and health of people with heart failure. Researchers enrolled 60 adults from California and gave them different weekly meal plans. They measured changes in di…

This study tested whether empagliflozin, a medication, could improve the structure and function of the heart in non-diabetic patients with a specific type of heart failure. Fifty patients were randomly assigned to receive either empagliflozin or a placebo pill daily for three mon…

This study tested whether a specialized clinic could help heart failure patients get the right medications at the right doses. Researchers compared 300 patients who received care through this clinic to similar patients getting usual care. The goal was to see if the clinic approac…

This study tested whether using a simple, daily bedside ultrasound scan to check a patient's fluid status could help doctors adjust heart failure medication more precisely. Researchers enrolled 250 adults hospitalized for acute heart failure to see if this approach led to fewer p…

This study tested if a diabetes medication called Empagliflozin could help improve the structure and pumping ability of the heart in people with diabetes who had a serious heart attack. It involved 200 participants who received one of two doses of the drug and were monitored for …

This study tested a new way to decide which older adults should get extra help from a care coordinator. Researchers wanted to see if asking people about their own difficulties managing care was better at preventing emergency room visits and hospital stays than the usual method, w…

This study tested whether a personalized, year-long exercise program could improve heart health and fitness in people with dilated cardiomyopathy, a condition where the heart muscle is weak. 300 participants were given an Apple Watch to track their activity and symptoms, with two…

This study tested a procedure called cryoballoon ablation, which uses extreme cold to treat an irregular heartbeat (atrial fibrillation) in people who also have severe heart failure. It aimed to see if this freezing technique is safe and effective at controlling the irregular rhy…

This study tested whether providing home-delivered, heart-healthy meals that include traditional Navajo foods could help people with heart failure stay healthier and avoid hospital visits. For 60 days, 206 participants either received these specially prepared meals or continued w…

This large, completed study tested two different drug combinations to see if they could help people with chronic heart failure live longer and stay out of the hospital. It involved about 1,100 participants with weakened hearts. One part tested a blood pressure drug combo (Hydrala…

This study tested whether providing full hospital-level medical care in patients' own homes is a safe and effective alternative to traditional hospital stays for rural adults. It involved 160 adults with serious but manageable conditions like severe infections, heart failure, COP…

This study tested if using a specific, step-by-step plan for adjusting water pills (diuretics) is better than doctors' usual judgment for adults hospitalized with worsening chronic heart failure. Researchers compared the two approaches in 299 patients to see which one was more ef…

This study tested whether a new injectable drug, AZD3427, could reduce high blood pressure in the lungs of people who also have heart failure. About 260 participants received either the drug or a placebo injection every two weeks for 24 weeks. The main goal was to see if the drug…

This study tested whether probenecid, a long-used gout medication, could help veterans with a common type of heart failure. Researchers gave 99 veterans either the drug or a placebo pill twice daily for six months to see if it improved their heart's pumping ability, exercise capa…

This study looked back at medical records of 1,249 patients with a weakened heart to compare two types of medications. Researchers wanted to see if a newer drug combination (sacubitril/valsartan) worked better than older standard drugs at preventing heart-related deaths and hospi…

This small, completed pilot study tested a procedure called pulmonary artery denervation (PADN) for people with chronic heart failure who also had high blood pressure in their lungs. The goal was to see if using a catheter to disrupt certain nerves in the lung artery was safe and…

This study tested whether providing 90 days of healthy food to heart failure patients after a hospital stay could improve their health and prevent return trips to the hospital. Researchers compared giving medically tailored meals, fresh produce boxes, or no food support to 150 pa…

This study observed how doctors use a special alert system called HeartInsight during routine care for heart failure patients. The system monitors data from implanted heart devices and warns doctors about potential worsening of heart failure. Researchers tracked about 150 alerts …

This small, completed pilot study tested whether a brief psychological exercise could help older adults with heart failure stick to their medication schedule. 43 participants in a cardiac rehab program were randomly assigned to either try a 'values affirmation' activity alongside…

This was a small, early-stage study to check if a new drug called CDR132L is safe for people with stable heart failure caused by heart disease. It involved 28 patients and compared the drug to a placebo. The main goal was to see how the body processes the drug and to identify any…

This study tested different support systems to help doctors better prescribe proven heart failure medications. Over 4,300 patients with weakened heart function participated across multiple clinics. Researchers compared usual care against computer alerts and pharmacist support to …

This study looked back at whether a specialized clinic for heart failure medication worked better than standard care. Researchers compared 342 patients who went to a clinic focused on giving the right heart medicines to similar patients who got usual care. They checked if patient…

This study tested whether a new drug called tovinontrine could help control chronic heart failure. It involved 557 adults with a weakened heart pump who were already on standard treatments. Researchers compared the drug to a placebo over 12 weeks, looking at changes in key blood …

This study compared two remote care approaches to help heart failure patients get the best possible medications. Researchers tested whether a structured virtual clinic or an education-first approach worked better at getting patients on recommended treatments. The trial involved 5…

This study monitored the safety of sacubitril/valsartan, a heart failure medication, in 8 Japanese children who had completed a previous trial. It allowed these children to continue receiving the medication while researchers tracked any side effects. The goal was to provide conti…

This small study tested whether taking a ketone salt supplement could improve heart function in people with heart failure. Twenty participants had two heart MRI scans: one after taking the ketone supplement and one after taking a carbohydrate placebo. The goal was to see if the s…

This study tested if placing a pacemaker lead in a new area of the heart (left bundle branch area) is better than the traditional placement (right ventricle) for people with a specific heart rhythm problem (AV block). Researchers wanted to see if the new method could better preve…

This study tested a French national support program (PRADO) for patients after a heart failure hospitalization. It aimed to see if better coordination between doctors and nurses for 2-6 months could reduce costly hospital readmissions and deaths. The research involved 404 patient…

This study aimed to find out if the order of doing aerobic exercise (like walking) and resistance training (like weights) in a single session affects heart function in men with chronic heart failure. It involved 60 men aged 55-65 who were divided into groups to test different exe…

This large study compared two commonly prescribed water pills (diuretics)—torsemide and furosemide—for people hospitalized with heart failure. Nearly 3,000 patients were randomly assigned to take one of these pills after leaving the hospital to see which one worked better. Resear…

This study tested whether giving heart patients an augmented reality app at discharge could help them better understand their care. Over 300 patients who had a heart attack, heart failure, or other heart conditions were given either standard paperwork or the paperwork plus an app…

This study tested whether a single daily pill containing three proven heart failure medications works better than giving the medications separately. It focused on low-income and racially diverse patients who often face barriers to getting optimal care. Researchers wanted to see i…

This small pilot study tested whether a support program could help older adults with heart failure manage their health at home. The program combined education before leaving the hospital, regular phone check-ins with a nurse, and sending daily health readings from home. Researche…

This study tested whether a newer pacing method (HIS/LBB pacing) works as well as standard biventricular pacing for people with heart failure and a specific electrical pattern in their heart. Researchers compared the two approaches in 150 patients over 6 months to see which bette…

This study tested whether a new extended-release version of the water pill torsemide helps remove more salt and fluid from the body after lunch compared to the standard immediate-release version. Twenty people with stable heart failure who were already taking water pills particip…

This study tested a new support program to help people in India better manage existing heart disease or stroke. The program combined non-doctor health workers, healthy lifestyle text messages, and a computer tool to guide treatment. Researchers wanted to see if this approach impr…

This pilot study tested whether a special exercise and lifestyle program is practical and safe for young cancer survivors who are at risk for heart problems. It involved 30 survivors aged 18-45 who had finished cancer treatment but had early signs of mild heart dysfunction. The m…

This study tested whether a portable ultrasound machine could accurately measure muscle loss in people with heart failure. Researchers compared the ultrasound results to standard X-ray scans in 48 participants, including healthy volunteers and heart failure patients. The goal was…

This study tested how accurately a new blood test (called BNP) can detect heart failure. Researchers compared the test results from a new lab machine to results from an older, established machine using blood samples from over 1,300 people. The goal was to make sure the new test g…

This study tested if sending a reminder to a patient's doctor could improve the diagnosis of heart failure. It focused on patients who had a high level of a certain blood marker (BNP) but had not recently had a heart scan. The goal was to see if the reminder prompted more scans, …

This study aimed to find better ways to diagnose a tricky form of heart failure that is common in older adults. Researchers tested a combination of five different markers in the blood of 91 participants to see if they could more accurately identify this specific condition. The go…

This study tested a new screening method to find heart failure earlier in older adults during regular doctor visits. Researchers used a simple questionnaire, a blood test, and a heart scan to check patients 65 and older who did not already have a heart failure diagnosis. The goal…

This study tested a special ultrasound machine that measures liver stiffness without surgery. Researchers wanted to see if this painless scan could replace invasive liver biopsies for diagnosing liver disease and monitoring heart failure patients. The study involved over 1,200 ad…

This study aimed to see if wearable motion sensors and 3D cameras could be used to measure movement problems in older adults with heart failure. Researchers tested these tools on 34 participants, including both healthy individuals and those with heart failure, to see if they coul…

This study tested whether giving doctors the results of a specific blood test (ST2) could help them better manage patients hospitalized for heart failure. The goal was to see if using this information could reduce the number of patients who need to be readmitted to the hospital w…

This study aimed to see if a special smartwatch could find patterns in a person's body signals and voice that might indicate heart failure. Researchers had 56 people, some with and some without heart failure, wear the device during clinic visits and record their voices at home. T…

This study tested a new, non-invasive device called Seerlinq HeartCore. It uses a simple finger sensor and a smartphone app to monitor a key pressure inside the heart for people with heart failure. The goal is to provide a safer, easier alternative to current invasive monitoring …

This study tested whether a specific low-sodium diet could prevent heart failure in Veterans at high risk. Researchers enrolled 71 Veterans with high blood pressure and metabolic syndrome to see if following the DASH diet (Dietary Approaches to Stop Hypertension) with reduced sal…

This study tested whether a special web-based program could help patients with heart failure, their family caregivers, and their nurses communicate better. The goal was to see if better communication could improve patients' quality of life and make care more focused on the patien…

This study tested whether a special website could help people caring for a family member with heart failure. Over 200 caregivers were randomly assigned to either use the website or receive standard support. Researchers measured if the website made caregivers feel more prepared, l…

This study tested if adding a fun, game-like activity called orienteering to standard heart rehabilitation is as good as regular walking. It involved 40 adults with various heart conditions who were already in a rehab program. Researchers measured heart rate, physical effort, and…

This study tested whether a home-based program combining heart failure management and palliative care could improve care for seriously ill heart failure patients. Researchers compared two approaches: doctors either had to actively choose to refer patients to the program (usual ca…

This study tested if a better way of teaching patients at hospital discharge could help them manage their heart failure. Researchers used a 'teach-back' method, where patients repeated their care instructions in their own words to ensure they understood. The goal was to improve p…

This study tested a 12-week support program designed for heart failure patients and the family members who care for them. The program focused on improving their relationship, building resilience, and reducing anxiety and depression. Researchers compared the program's effects to s…

This study tested whether a simple mobile device could help older hospital patients be more active. About 130 patients with conditions like COPD, heart failure, or frailty were randomly assigned to either use the device or not. The device gave visual feedback on their movement, a…

This study looked at whether using a standard questionnaire could help identify the spiritual needs of seriously ill patients in palliative care. Researchers wanted to see if this method made it easier for hospital chaplains to provide timely and appropriate spiritual support. Th…

This study tested whether a WhatsApp-based program could help people with heart failure sleep better and improve their quality of life. Researchers enrolled 28 patients with heart failure and poor sleep. Participants received personalized sleep tips and reminders through WhatsApp…

This study tested if a new, longer-acting version of a common water pill (torsemide) could better control overactive bladder symptoms like frequent and urgent urination in people with chronic heart failure. It compared this extended-release version against the standard, immediate…

This study tested a 6-month coaching program designed to help heart failure patients and their family caregivers better manage the challenges of the illness. The program provided education and support to improve quality of life and coping skills. Researchers wanted to see if this…

This study tested a program designed to support the family and friends who care for people with advanced heart failure. The program, delivered by a nurse in the caregiver's home, helped participants set personal health goals, manage stress, and reduce feelings of burden. Research…

This study tested whether teaching heart failure patients about healthy eating through animated videos could help them eat better, feel better, and improve their quality of life. Researchers worked with 70 patients, giving half of them the video lessons while the other half recei…

This study tested new MRI scanning methods to get clearer pictures of bleeding inside the heart muscle after a heart attack. Researchers enrolled 14 patients who had recently had a heart attack to see if these new scans could better identify damage and predict who might develop f…

This study aimed to see if a special ultrasound scan of the liver could help doctors spot heart problems after major heart surgery. Researchers followed 32 patients who had heart surgery to see if changes in blood flow to the liver were linked to poor heart function. The goal was…

This study aimed to understand how health knowledge, stress levels, and quality of life are connected in people living with heart failure. Researchers surveyed 158 heart failure patients in Taiwan, asking them questions about their health understanding, stress, and daily life cha…

This study observed 254 Mexican adults with a specific type of heart failure to understand their real-world treatment and progress. Researchers collected data on the medications and devices patients received, tracked survival rates, and identified any barriers to getting recommen…

This study aimed to understand how children with heart failure breathe and sleep, and to see if using a CPAP machine (a device that provides gentle air pressure) while awake could make breathing easier and potentially help their heart function. It involved 30 children, from infan…

This international registry collected information from 383 patients who received specialized pacemakers for slow heart rhythms or heart failure. Researchers tracked how doctors used new pacing techniques in real-world practice to understand their benefits and limitations. The goa…

This study looked at how well German heart failure clinics followed established treatment guidelines for patients with weakened heart muscles after a serious health episode. Researchers collected data from 899 patients across different types of clinics to compare care quality. Th…

This study aimed to understand why some patients with heart failure end up back in the emergency room or hospital within 30 days of being discharged. Researchers looked at the medical records of 58 patients to find the main reasons for these quick returns. The goal was to use thi…

This study looked back at the medical records of over 13,600 heart failure patients in France from 2021 to 2024. It tracked how often doctors prescribed a specific type of medication called SGLT2 inhibitors. The goal was to understand prescription trends and what factors influenc…

This study tested whether a computer algorithm could predict when patients receiving hospital-level care at home might get sicker. Researchers used past patient data to train the algorithm and then checked how well it worked on a new group of over 500 patients. The goal was to se…

This study observed 257 patients in Greece who were newly prescribed dapagliflozin for heart failure. The goal was to understand how patients use the medication in real life and how it affects their quality of life. Researchers tracked whether patients continued taking the drug a…

This study aimed to understand if raising ketone levels in the blood could improve how the heart pumps in people with both type 2 diabetes and heart failure. Researchers gave 41 participants infusions of ketones at different levels and used heart scans (MRI and PET) to measure ch…

This study aimed to confirm the safety of specific heart devices (SureScan pacemakers and defibrillators) when patients undergo a 3.0T MRI scan. It involved 64 adults who already had one of these devices implanted. Researchers monitored the participants to see if the powerful MRI…

This was a very early safety study for a new drug called THRV-1268, which is being developed for heart failure. Researchers gave single doses to 16 healthy but obese adults to see if it was safe and to measure how the body processes it. The main goal was to check for side effects…

This study was a survey of 608 heart and kidney specialists. Its purpose was to understand how these doctors think about and use a specific blood test (hsCRP) to detect hidden inflammation in patients with combined heart and kidney diseases. The goal was to gather real-world info…

This study aimed to find out whether animated videos or written text are better for teaching heart failure patients about their condition. Researchers at Stanford University enrolled 130 people with heart failure and randomly assigned them to learn using videos, text, or a mix of…

This study explored whether signs of heart failure can be detected in fluid collected just under the skin, rather than through blood tests. Researchers tested a new device on 20 heart failure patients to see if it could measure these signs during exercise. The goal was to underst…

This study tested a new way to give a common fluid-reducing drug (furosemide) as a shot under the skin, comparing it to the standard method of giving it into a vein. The goal was to see how the body processes the drug and how well it works when given differently. It involved 21 h…

This study looked back at past patient records to see if a computer program could learn to predict which patients are most likely to be readmitted to the hospital within 30 days after being sent home. Researchers used data from 372 patients who had been treated at home through a …

This study aimed to understand exactly how beta-blocker medications help improve heart function in people with severe heart failure. Researchers studied 55 adults with weakened heart muscles to see if the drugs make the heart muscle itself contract more strongly. They also tested…

This study aimed to understand why people with chronic kidney disease often develop serious heart problems. Researchers used special heart scans (MRI) on 276 patients with kidney disease to look for patterns of heart damage, scarring, and swelling. The goal was to identify the sp…

This study looked at data from a global safety database to see if certain heart failure medications are linked to a higher risk of falls in people aged 65 and older. Researchers analyzed over 100,000 reports to check if some drug classes, or specific drugs within them, were assoc…

This study aimed to understand why a common heart failure medication (Entresto/LCZ696) can sometimes cause a significant drop in blood pressure. Researchers tested 46 stable heart failure patients to see if a natural body chemical called substance P is responsible for this effect…

This study looked at how COVID-19 lockdowns in France impacted people with long-term health conditions like heart disease, multiple sclerosis, and cancer. Researchers followed over 1,300 patients to see if lockdowns changed their medication use, lifestyle habits, and access to me…

This study translated and tested a standard heart failure quality-of-life questionnaire into Urdu, the national language of Pakistan. Researchers gave the survey to 210 heart failure patients to check if it was reliable and valid for use in their culture. The goal is to provide d…

This study collected detailed health information from over 2,400 patients with heart failure, both during hospital stays and outpatient visits. The goal was to analyze this data to understand patient risks better and create a more personalized care model. Researchers aimed to use…

This study tested whether using a heart ultrasound machine during pacemaker implantation helps doctors place the wires more accurately. Researchers wanted to see if this method reduces surgery time and lowers the amount of X-ray radiation needed during the procedure. They compare…

This study looked back at the medical records of 4,000 heart failure patients to see if combining information from common blood tests and heart scans could better predict a patient's risk of dying within one year. The goal is to help doctors make more accurate, personalized risk …