HEART FAILURE

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study investigates whether a home-based cardiac rehabilitation program, tailored to each patient's readiness to change, can improve self-care, quality of life, and confidence in people with heart failure. The program involves home visits and phone counseling over 12 weeks. R…

This study tested a new drug called R2R01 in 33 people with worsening heart failure. Participants received either R2R01 or a placebo alongside their usual treatments. The goal was to see if the drug is safe and helps reduce fluid buildup in the heart.

This study tests a new medicine called NNC0537-1482, designed to potentially treat heart failure. It is the first time this drug is given to humans, so healthy volunteers receive a single injection under the skin to check for safety and how the body processes it. Participants are…

This study tested whether starting the drug dapagliflozin during a hospital stay for acute heart failure can reduce the risk of death or worsening heart failure. Over 2,400 adults who were stable after initial treatment were randomly given either dapagliflozin or a placebo. The g…

This study tested a new way to give the heart failure drug furosemide: as a shot under the skin instead of through an IV. Twenty adults with chronic heart failure received both versions to compare how much drug gets into the body. The goal is to see if the shot works well enough …

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This completed study in 180 heart failure patients compared the effects of taking Entresto alone versus Entresto plus a second drug (empagliflozin) on mitral valve function and heart pumping ability. Participants had heart failure with reduced ejection fraction and some degree of…

This study looked at whether adding semaglutide (a drug used for diabetes and weight loss) to the standard heart failure medication dapagliflozin helps people with heart failure who have had a surgical heart valve replacement. 160 participants were split into two groups: one got …

This study tested whether placing the left ventricle lead of a cardiac resynchronization therapy (CRT) device at the heart's latest electrical activation spot improves outcomes. It included 1,000 heart failure patients with bundle branch block. The goal was to see if this targete…

This study tested a mobile app designed to help people with heart failure monitor their blood pressure, weight, and heart rate daily. The app also tracks symptoms and medications, sharing the data with doctors to guide treatment. Researchers wanted to see if using the app leads t…

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the main …

This study tested a new way to help heart failure patients with weak hearts get the right medications. Over 2,400 people with a heart device took part. A nurse used a simple checklist to guide doctors in prescribing better treatments, aiming to reduce hospital visits and improve …

This study tested whether catheter ablation (a procedure to fix irregular heart rhythm) is better than standard rate-control medication for people with both atrial fibrillation and heart failure. Over 400 participants were randomly assigned to either ablation or medication. The m…

This study tested whether sacubitril/valsartan (Entresto) works better than enalapril for people with heart failure caused by chronic Chagas disease. Over 900 adults with reduced heart function took part. The goal was to see if the drug could reduce heart-related deaths, hospital…

This early study tested a single injection of HM2002, a circular RNA, given directly into the heart muscle during bypass surgery. Only 3 people with heart failure took part. The main goal was to check safety, not to prove it works. The study is complete, but results are not yet a…

This study tested whether a new way of processing tissue for Edwards heart valves is safe and works well. 777 adults who needed a new aortic or mitral valve took part. Researchers checked for valve problems like wear or calcification over about a year, and will follow patients fo…

This study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise ability and blood vessel function in people with heart failure. Ten participants took either the probiotic or a placebo. The goal was to see if the probiotic could…

This study tested whether a small wearable sensor, combined with a smart computer program, could detect early signs of worsening heart failure and alert doctors to adjust treatment before a hospital stay is needed. Researchers enrolled 176 veterans with heart failure and randomly…

This study looked at whether a diabetes drug called empagliflozin, combined with a breathing machine (CPAP), can improve sleep and heart function in 70 adults with both heart failure and obstructive sleep apnea. Participants were randomly assigned to take empagliflozin or not, an…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study tested whether low doses of digoxin, an old and cheap heart drug, can reduce hospitalizations and death in 982 heart failure patients. Participants received either digoxin or a placebo pill. The goal is to see if keeping digoxin levels low in the blood improves outcome…

This study tested a device called the DuoCor Ventricular Assist System, an implantable heart pump for people with advanced heart failure. Eight adult patients who needed support for both sides of the heart received the pump. The main goal was to see if patients survived for 3 mon…

This study tested a drug called sacubitril-valsartan in 60 adults with heart failure and a weak heart pump. The goal was to see if the drug could lower the chance of major heart problems like heart attack, stroke, or death, and improve how well the heart pumps blood. Participants…

This pilot study tested a new, very small lead (under 2 French) designed to improve cardiac resynchronization therapy (CRT) for heart failure. In 20 patients getting a standard CRT device, doctors temporarily placed the new lead to see if it could pace the heart's left ventricle …

This study tested whether a short course of doxycycline, a common antibiotic, can prevent heart damage after a heart attack. 174 adults who had a severe heart attack received either doxycycline or a placebo twice daily for one week. Researchers then used MRI scans to check heart …

This early-stage trial tested a new cell therapy called CAR-DC in 8 people with end-stage dilated cardiomyopathy, a condition that weakens the heart. The therapy targets a protein called FAP to calm the immune system and improve heart function. The main goal was to check safety, …

This study looked at whether closer collaboration between doctors and pharmacists could reduce hospital readmissions for people with heart failure. About 229 adults hospitalized for heart failure took part. Researchers compared standard care to a more coordinated approach where p…

This study looked at whether a drug called sacubitril/valsartan helps African American patients with a certain type of heart failure (reduced ejection fraction). Researchers wanted to see if it lowers the chance of death or hospital visits for heart problems. Over 6,500 African A…

This completed study monitored 1200 Japanese patients with chronic heart failure who were prescribed JARDIANCE® (empagliflozin) for the first time. Researchers tracked side effects, deaths, and hospitalizations over the long term to see how the drug performs in everyday use. The …

Heart failure patients often struggle after leaving the hospital, leading to high readmission rates. This study tested a nurse-led smartphone app that provides medication reminders, symptom tracking, and team support. Half of the 104 participants used the app plus standard care, …

This study tested whether daily bedside ultrasound scans help doctors better adjust treatment for people hospitalized with acute heart failure. The goal was to see if this approach reduces the number of patients readmitted within 30 days. The study involved 250 adults with heart …

This trial tested a device called Barostim neo that stimulates nerves to help control blood pressure in people with advanced heart failure. Over 1,000 participants received either the device or standard medical care. The goal was to see if the device could reduce heart-related de…

This study tested whether an extended-release version of the diuretic torsemide helps heart failure patients get rid of more salt after lunch compared to the standard immediate-release version. Twenty adults with stable heart failure took both forms in a random order, and researc…

This study tested a comprehensive digital health program for people with heart failure after they leave the hospital. The program included cognitive behavioral therapy, self-monitoring via smartphone, and a special device to track lung fluid. Researchers measured how well patient…

This study tested a new way to care for people with heart failure after they leave the hospital. Over 500 patients used a home monitoring system to track symptoms and weight, along with nurse education and a follow-up visit. The goal was to see if this approach could reduce hospi…

This study tested whether a structured discharge education session using the 'teach-back' method—where patients repeat instructions in their own words—could help heart failure patients better understand their condition and self-care routines. The goal was to reduce 30-day hospita…

This study looked at two different types of follow-up care for people with heart failure after they leave the hospital. One group got a phone call from a care coordinator, while the other could request a home visit from a community paramedic who could connect them to a doctor by …

This study compared a newer pacing method, called HIS or left bundle branch (LBB) pacing, to the standard biventricular pacing in 150 heart failure patients with a specific heart electrical problem (left bundle branch block). The goal was to see if the new method could improve he…

This study looked at 652 heart failure patients who had a special heart device (CRT). One group received standard remote monitoring, while the other got more detailed monitoring that also tracked heart rhythm issues and symptoms. The goal was to see if the extra monitoring could …

This pilot study tested a very small, specially shaped heart lead (less than 2 French) in 39 adults getting a cardiac resynchronization therapy device. The goal was to see if the lead could successfully pace the left ventricle from two distant spots. Researchers measured pacing s…

This study tested two remote care strategies to help heart failure patients get the right medications. 503 adults with heart failure were randomly assigned to either immediate medication start or education first. The goal was to see which approach led to more patients using recom…

This study looked at health records of 1,249 heart failure patients in Portugal to compare two types of medication: sacubitril/valsartan versus older drugs called ACE inhibitors or ARBs. The goal was to see which treatment better prevents heart failure hospitalizations or death f…

This study tested whether a step-by-step plan for using diuretics (water pills) is better and safer than usual care for people hospitalized with worsening chronic heart failure. The trial involved 299 adults and compared a structured protocol using furosemide and hydrochlorothiaz…

This study tested whether providing medically tailored meals to people with heart failure could improve their diet quality. Sixty participants received heart-healthy meals delivered to their homes for 12 weeks. The main goal was to see if their diet scores improved by the end of …

This study tested a program to help people with heart disease, stroke, or heart failure in India. The program used non-physician health workers, text messages about healthy living, and a computer tool to help doctors make decisions. 410 adults took part to see if the program impr…

This study looked at whether high-intensity breathing exercises (inspiratory muscle training) can improve blood vessel function and artery stiffness in people with heart disease before they start cardiac rehab. Eleven adults who had heart surgery or related conditions took part. …

This pilot study tested a procedure called pulmonary artery denervation (PADN) in 30 adults with combined high blood pressure in the lungs and chronic heart failure. The procedure uses radiofrequency energy to disrupt certain nerves in the lung's blood vessels, aiming to lower pr…

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study tested whether Medtronic SureScan pacemakers and defibrillators are safe during 3.0T MRI scans anywhere on the body. 64 adults with these devices received an MRI scan and were followed for one month. The goal was to see if any serious problems occurred, such as device …

This early-phase trial tested a single dose of the investigational drug THRV-1268 in 16 healthy obese adults to see if it is safe and tolerable. The drug is being developed as a potential treatment for heart failure. The study did not test effectiveness, only safety and how the d…

This completed Phase 3 trial tested a web application called SmartHF in 225 adults with heart failure and reduced ejection fraction. The app analyzes patient data and gives personalized medication recommendations that patients can share with their doctor. The goal was to see if u…

This early-stage study tested a new drug called CDR132L in 28 people with stable heart failure caused by reduced blood flow to the heart. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and research…

This study tested whether probenecid, a medicine usually used for gout, can improve heart function and exercise ability in veterans with heart failure. About 99 veterans with a specific type of heart failure took probenecid twice daily for 180 days. Researchers measured changes i…

This study tested a newer pacing method (left bundle branch area pacing) against the standard method (right ventricular pacing) in 486 adults with atrioventricular block, a condition where the heart's electrical signals are delayed. The goal was to see if the newer method better …

This study looked at whether providing pre-made, heart-healthy meals that include traditional Navajo foods could help people with heart failure avoid hospital stays or emergency room visits. Over 200 participants either received these meals for 60 days or continued their usual ca…

This study tested a remote monitoring system called Seerlinq HeartCore in 330 heart failure patients. Participants used a device at home to measure heart function and report symptoms. The goal was to see if this approach could reduce hospitalizations and deaths over 6 months. The…

This study tested whether a medicine called henagliflozin can reduce the size of heart damage and improve heart function in people who had a severe heart attack. 248 adults took the drug or a placebo for 6 months after a procedure to open blocked arteries. Researchers measured he…

This pilot study tested whether a structured exercise program is feasible for young cancer survivors (ages 18-45) who have mild heart dysfunction after cancer treatment. The program, called CORE, is like cardiac rehab and aims to improve heart health, fitness, and quality of life…

This completed study tested whether empagliflozin, a diabetes drug, can improve heart structure and function in 50 non-diabetic patients with heart failure with preserved ejection fraction. Participants took either empagliflozin or a placebo daily. Researchers measured heart stre…

This study looked at whether a clinic led by a heart failure nurse could help patients with heart failure get the right medications after getting an implantable defibrillator (ICD) or cardiac resynchronization therapy (CRT). The goal was to see if this approach improved heart fun…

This study tested whether a single daily pill containing three heart failure drugs could help people with reduced ejection fraction, especially those with low income or from minority groups. 212 adults took either the polypill or standard separate medications. The goal was to see…

This Phase 2 trial tested the drug tovinontrine (CRD-750) against a placebo in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug safely lowers a key heart stress marker called NT-proBNP over 12 weeks. The study is complete, and res…

This Phase 2 study tested the safety and effectiveness of tovinontrine, an experimental drug, compared to a placebo in 303 adults with chronic heart failure with preserved ejection fraction. The main goal was to see if tovinontrine could lower a key biomarker (NT-proBNP) in the b…

This study looked at whether giving heart failure patients either medically tailored meals or fresh produce boxes after a hospital stay could improve their health and reduce return visits to the hospital. 150 adults who had been hospitalized for heart failure were randomly assign…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a device called MitraClip in 162 heart failure patients with a leaky mitral valve (mitral regurgitation). The device is clipped onto the valve to reduce leakage. The goal was to see if it is safe and effective in real-world conditions. All patients had severe sy…

This pilot study tested a program where community health workers (CHWs) provided follow-up calls and home visits to heart failure patients after hospital discharge in rural Haiti. The goal was to see if the program was acceptable and feasible for patients, CHWs, and healthcare st…

This study tested a standardized care plan to protect the right side of the heart after a left ventricular assist device (LVAD) implant. Twenty adults receiving an LVAD were given either the standardized care or usual care. The goal was to see if the new approach could prevent ri…

This study compared two common water pills (torsemide vs furosemide) in nearly 3,000 adults hospitalized with heart failure. The goal was to see which drug better prevents death or the need for repeat hospitalizations over 12 months. Participants were randomly assigned to one of …

This completed study looked at whether a dedicated clinic focused on guideline-directed medical therapy (GDMT) helps heart failure patients get the right combination of medications. Researchers analyzed data from 342 patients at Massachusetts General Hospital who attended the GDM…

This study looked at the safety of the drug sacubitril/valsartan in Japanese children with heart failure. Eight children who had already been in a previous trial took the drug to see if any side effects occurred. The goal was to gather more safety information and provide the drug…

This early-phase study tested whether the heart medication carvedilol could safely protect breast cancer patients from heart damage caused by chemotherapy drugs like doxorubicin and trastuzumab. 68 women with early-stage breast cancer were assigned to either receive carvedilol or…

This completed phase 4 trial tested whether vericiguat, a drug already approved for heart failure, can improve blood vessel function, reduce inflammation, and enhance quality of life in 26 people with heart failure with reduced ejection fraction. Participants received either veri…

This study tested a program called PRADO that helps heart failure patients transition from hospital to home care. It included 404 adults who had been hospitalized for heart failure and lived at home. The program aimed to reduce hospital readmissions and deaths by coordinating doc…

This study tested an experimental drug called AZD3427 in 260 adults with heart failure and a type of high blood pressure in the lungs (pulmonary hypertension). The goal was to see if the drug could lower pressure in the lung's blood vessels after 24 weeks of treatment. Participan…

This study tested whether a special clinic (GDMT Clinic) helps heart failure patients get the right medications compared to usual care. About 300 adults with heart failure took part over 12 weeks. The clinic aimed to improve medication use, health status, and heart function.

This completed study tested whether special alerts in electronic health records and referrals to pharmacists could help doctors prescribe guideline-recommended heart failure medications more often. Over 4,300 patients with heart failure and reduced ejection fraction took part. Th…

This study tested a pacemaker feature called AutoAdapt that automatically adjusts timing settings to help the heart pump better. It involved 198 people with heart failure who needed a special pacemaker. The goal was to see if this smart feature improves symptoms, reduces hospital…

This completed study tested whether SGLT2 inhibitors (dapagliflozin or empagliflozin), taken daily, can reduce heart failure hospitalizations, repeat heart attacks, and death in 450 non-diabetic patients who had a heart attack treated with stenting. Participants received the drug…

This study tested a procedure called cryoballoon ablation in 1,420 people with atrial fibrillation (an irregular heartbeat) and severe heart failure. The goal was to see if freezing the veins that trigger the irregular rhythm could reduce recurrence of the heart rhythm problem an…

This completed study looked at whether the diabetes drug empagliflozin (Jardiance) can help repair heart damage in diabetic patients who had a major heart attack. 200 participants took either 10 mg or 25 mg of the drug daily for 6 months. Researchers measured changes in heart siz…

This study tested whether a special smartwatch (Watch HOP) can help detect heart failure by measuring heart rate, movement, skin temperature, and voice patterns. Researchers compared 56 people with and without heart failure during physical tasks and daily life. The goal is to fin…

This completed study tested a structured heart failure screening pathway for adults aged 65 and older during routine general practice visits. The screening involved a questionnaire, a blood test (NT-proBNP), and an echocardiogram. Researchers aimed to see how many patients would …

Heart failure is a serious condition with high death and rehospitalization rates. This study tested whether using a blood marker called ST2 to guide treatment could reduce hospital readmissions within one month. Researchers compared standard care with a strategy that adjusts medi…

This study tested a new blood test called HEARTBiT that uses 9 RNA markers to detect acute rejection in heart transplant patients. Currently, rejection is found through frequent, invasive heart biopsies. The test was developed using samples from 150 patients and will be evaluated…

This study tested whether a special ultrasound, called ShearWave Elastography, can measure liver stiffness without needing a needle biopsy. Over 1,200 adults with chronic liver disease, liver transplants, or heart failure had a quick scan during a regular clinic visit. The goal w…

This study checks if a portable ultrasound device can accurately measure muscle and fat loss in people with heart failure. Researchers compared ultrasound results to the standard DXA scan in 48 participants, including healthy volunteers and heart failure patients. If validated, t…

This study tested a new device called Seerlinq HeartCore that uses light sensors (photoplethysmography) to measure heart pressure without needles or catheters. Researchers enrolled 131 adults with heart failure to see if the device could accurately detect elevated filling pressur…

This study tested a new BNP blood test on 1,361 people to see how well it identifies heart failure. The test measures a substance in the blood that can indicate heart strain. Researchers compared the test results to standard methods to check accuracy. The goal is to give doctors …

This study aimed to create better diagnostic tools for a type of heart failure called heart failure with preserved ejection fraction (HFpEF), which is common in older adults but hard to diagnose. Researchers tested a combination of five blood markers in 91 participants to see if …

This study tested whether nebivolol, a beta-blocker heart drug, could prevent heart failure in 51 boys aged 10-15 with Duchenne muscular dystrophy. Participants had normal heart function at the start and were randomly given either nebivolol or a placebo. The trial found that nebi…

This study tested whether a low-salt, heart-healthy diet (DASH diet) can prevent heart failure in veterans with high blood pressure and metabolic syndrome. 71 veterans received counseling and some also got tailored messages via smartphone or email. The goal was to see if the diet…

This study tests whether starting cardiopulmonary rehabilitation (exercise and breathing training) early in the hospital helps people with acute decompensated heart failure recover faster. About 40 adults who are stable enough will take part. The goal is to see if early rehab imp…

This study tested a phone-based system that helps people with heart failure monitor their symptoms and get coaching on how to manage them at home. 50 patients used the system after being discharged from the hospital. The goal was to see if the system could help patients better ca…

This study tested whether adding leg compression to standard diuretic treatment helps people hospitalized with heart failure and severe fluid buildup. 106 adults received either diuretics alone or diuretics plus leg compression for up to 72 hours. Researchers measured changes in …

This study tested a 24-week sleep program delivered partly through WhatsApp for people with heart failure and poor sleep. The program included education, daily tips, and smartwatch sleep tracking. Researchers measured sleep quality, sleep habits, and quality of life in 28 partici…

This study tested whether a 12-week home-based walking program could help heart failure patients with depression, frailty, and quality of life. 68 patients were split into two groups: one got standard health education, the other added a walking routine of 3,000 extra steps per se…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether a home-based exercise program is practical for people with chronic heart failure who have just been hospitalized. Thirty patients were taught exercises by a physiotherapist and did them at home for 12 weeks. The goal was to see how many completed the pro…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study looked at whether high-intensity interval training (short bursts of hard exercise) is better than moderate continuous exercise for people with heart failure. Researchers measured nerve activity, blood vessel function, and muscle health in 35 participants. The goal was …

This early study tested a new patch-like device that delivers the heart failure drug furosemide under the skin. Twenty hospitalized heart failure patients received a single dose to see if it is safe and works well. The goal is to find a simpler way to give this medication without…

This study tested whether heart failure patients can do cardiac rehabilitation at home using a tablet app instead of going to the hospital. Thirty stable patients were split into two groups: one did rehab at home with remote monitoring, the other at the hospital. The goal was to …

This pilot study tested whether a set of lymphatic exercises could reduce fluid overload symptoms like shortness of breath, leg swelling, and fatigue in people with heart failure. Eighty participants were randomly assigned to either do the exercises twice daily for four weeks or …

This study tested a technology-based program (T-FAME) that helps heart failure patients and their families manage care at home after a hospital stay. The program uses a smartphone app to support self-care and family involvement, aiming to improve quality of life and reduce hospit…

This phase 2 trial tested whether a new wearable pump that delivers a water pill (furosemide) under the skin could help heart failure patients leave the hospital earlier. 172 adults admitted for heart failure were randomly assigned to either go home with the pump or stay in the h…

This study tested whether a personalized exercise program, guided by an Apple Watch, can improve fitness and well-being in people with dilated cardiomyopathy, a condition that weakens the heart. 300 adults aged 18-65 with the condition took part over 13 months. The main goal was …

This study tested a web-based program called 'Heart to Heart' for people with heart failure, their family caregivers, and cardiac nurses. The goal was to improve quality of life and communication. 150 participants completed the program, which focused on family-centered care and p…

This study tested whether an extended-release version of the diuretic torsemide works better than the standard immediate-release form for reducing overactive bladder symptoms in people with chronic heart failure. Twenty-four participants took each version for four weeks, tracking…

This study tested a program called Advanced Heart Care at Home (AHCAH) that brings heart failure and palliative care into patients' homes. Doctors of 709 seriously ill heart failure patients were randomly assigned to either usual care or a 'nudge' encouraging them to enroll their…

This study tested whether watching animated nutrition videos helps people with heart failure improve their eating habits, reduce symptoms, and feel better overall. 70 adults aged 45-60 with moderate heart failure took part. One group watched the videos and got standard care, whil…

This study tested whether a single dose of a ketone salt supplement could improve heart function in 20 people with stable heart failure. Participants took either the ketone supplement or a carbohydrate placebo before a heart MRI. The goal was to see if the supplement could help t…

This study looked at whether doing resistance or aerobic exercise first during a rehab session affects heart function in men with chronic heart failure. Sixty men aged 55-65 with reduced heart pumping ability took part. Researchers measured heart function and quality of life to s…

This study looked at whether a cardiac rehab program with two types of aerobic exercise could help heart failure patients who also have muscle loss (sarcopenia). 22 patients aged 18-75 with moderate heart failure took part. The goal was to see if exercise improves their breathing…

This pilot study tested whether a brief values-affirmation exercise could help older adults with heart failure stick to their medications. 43 participants in cardiac rehabilitation either did the exercise plus usual care or just usual care. The study focused on whether the approa…

This study tested a program for caregivers of people with advanced heart failure. The program helps caregivers build on their strengths, find purpose, and set goals for a healthier lifestyle. Researchers wanted to see if it could improve caregivers' quality of life, reduce their …

This study tested a 12-week telephone-based program for heart failure patients and their family caregivers. The program included six weekly sessions followed by four follow-up calls, focusing on improving the relationship between patient and caregiver, as well as each person's re…

This pilot study tested a 6-month nurse coaching program called ENABLE for heart failure patients and their caregivers in Singapore. The program aims to educate, nurture, and advise patients and caregivers to improve quality of life. The study enrolled 125 participants to see if …

This study tested whether an internet-based support program helps caregivers of people with heart failure feel more prepared and supported. About 202 caregivers from four healthcare regions took part. The program provided education and a chance to share experiences. Results showe…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This completed study looked at 26,000 adults with chronic heart failure in France who used a web app for remote monitoring. Researchers compared those who were digitally literate with those who were not, tracking hospitalizations and death rates. The goal was to understand whethe…

This study tested whether a nurse-led education program helps people with heart failure improve their self-care, medication and diet compliance, and confidence in managing their condition. Researchers enrolled 66 adults with stable heart failure and provided a 30-minute training …

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This early-stage trial tested the safety and tolerability of a new drug called SHR-6934 in 88 healthy adults. Participants received either the drug or a placebo as a single or multiple injections under the skin. The goal was not to treat any disease, but to gather important safet…

This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormo…

This study looked at how certain heart devices change a blood-clotting protein called von Willebrand factor. Researchers studied 500 adults with heart failure or aortic stenosis who received a mechanical heart pump or a valve replacement. The goal was to understand when these pro…

This study looked at 502 people with heart failure who were getting an implantable defibrillator (ICD) to prevent sudden cardiac arrest. Researchers used a special MRI to see if heart scarring patterns could predict who would later need a shock from the device. The goal was to le…

This study looked at how high-intensity interval training (HIIT) changes heart cells in people with heart failure. Forty stable patients were split into two groups: one did 36 sessions of HIIT plus standard medication, the other took medication only. Researchers measured fitness,…

This study observed 49 adults hospitalized with acute heart failure to learn how fluid congestion behaves during treatment. Researchers tracked clinical signs, lab tests, and ultrasound measures, then followed patients for a year to see who was readmitted or died. The goal is to …

This study tested a computer alert that pops up in doctors' electronic health records to remind them to prescribe recommended heart failure medications. Over 1,100 patients with a specific type of heart failure (reduced ejection fraction) took part across four health systems. The…

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study tested whether simple nudges—like an alert in a doctor's daily task list or an email comparing their prescribing habits to peers—could increase the use of two types of heart failure medications (SGLT2 inhibitors and MRAs) that are proven to save lives but are often und…

This study looked at whether being physically active over a lifetime is linked to developing a rare heart disease called wild-type transthyretin amyloid cardiomyopathy. Researchers compared the exercise histories of 180 people over age 60, including those with the disease, those …

This completed study with over 1,000 participants looked at whether patient surveys and interviews can help doctors spot changes in heart failure. Researchers also collected blood samples to explore links between biology and quality of life. The goal was to see if these tools are…

This study tested a device that automatically measures foot volume to help monitor fluid levels in heart failure patients. Researchers wanted to see if it could help doctors adjust diuretic treatment at home and detect early signs of fluid overload before a hospital stay. The stu…

This study tested whether sending digital letters to heart failure patients could help them start taking SGLT-2 inhibitors, a newer heart failure medication, more quickly. Over 5,900 patients in Denmark were invited via digital letter to see a specialist and check if they were el…

This study looked at over 31,000 cancer patients to see if an AI-enhanced electrocardiogram (ECG) could predict heart damage caused by chemotherapy. Researchers analyzed existing ECGs taken before treatment to see if the AI could identify those at risk. The goal is to develop a s…

This study tested whether routinely asking heart failure patients a 12-question survey about their symptoms and quality of life during clinic visits leads to better care. Over 1,200 participants were randomly assigned to start the survey right away or after a one-year delay. Rese…

This study tested whether artificial intelligence (AI) could predict a person's risk of developing a specific type of heart failure (HFrEF) up to 5 years in the future, using only a standard ECG. Researchers analyzed data from over 286,000 adults in China and the US. The goal was…

This study looked at 623 adults with heart failure or high blood pressure in the lungs to see how well different tests measure pressure inside the heart. Doctors used both non-invasive ultrasound (echocardiogram) and invasive catheter measurements to check for elevated filling pr…

This study tested two types of cameras—a newer CZT camera and a standard Anger camera—to see how well they measure heart nerve function in people with heart failure. Forty-five patients received a special tracer injection (I-123-MIBG) and were scanned with both cameras. The goal …

This study tested whether using cardiac MRI (a type of scan without radiation) can make heart exams safer and more accurate for children with heart failure, heart defects, or who have had a heart transplant. Researchers compared MRI results with standard biopsy and X-ray methods …

This early-stage study tested a new version of the water pill furosemide that can be injected under the skin (subcutaneous) using an autoinjector, comparing it to the standard IV form given in a hospital. The study involved 21 healthy volunteers aged 45 to 80 to see how the drug …

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This completed observational study looked at how often heart failure patients in a French nationwide remote monitoring program were prescribed SGLT2 inhibitors between 2021 and 2024. Researchers analyzed data from over 13,600 adults to see how prescription rates changed over time…

This study tested whether heart failure patients learn more from watching videos or reading text about their condition. 130 patients with heart failure took part. They were randomly assigned to video or text modules, then tested on their knowledge. The goal is to find the best wa…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study translated the Minnesota Living with Heart Failure Questionnaire into Urdu and tested it with 210 heart failure patients in Pakistan. The goal was to ensure the Urdu version is accurate and reliable for measuring quality of life. This is a validation study, not a treat…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study looked at how the heart failure drug Entresto (LCZ696) lowers blood pressure and helps the body get rid of salt. 46 stable heart failure patients took part. Researchers measured blood pressure and urine sodium levels to understand the drug's effects.

This completed study looked at 158 heart failure patients aged 18-65 to see how health literacy and stress relate to their quality of life. Researchers used machine learning to analyze survey data. The goal was to find patterns that could help nurses and doctors better support pa…

This study looked at data from over 2,400 people with heart failure to find better ways to predict who is at risk for serious events like death or hospital stays. Researchers tested a care model that uses risk scores to guide treatment. The goal was to improve survival and reduce…

This study looked at whether signs of heart failure can be found in fluid just under the skin, called dermal interstitial fluid. Researchers tested 20 heart failure patients using a special device to collect this fluid during exercise. The goal was to see if these skin-based mark…

This pilot study tested whether a program combining nurse-led telephone coaching and home telemonitoring of vital signs is feasible and acceptable for older adults with heart failure. 46 patients hospitalized for heart failure were enrolled. The study focused on recruitment, rete…

This study gathered information from 383 people with slow heartbeats or heart failure who received a special type of pacemaker called conduction system pacing. Researchers looked at how well the device worked, any complications, and changes in heart function over 12 months. The g…

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study surveyed 608 heart and kidney doctors to understand their awareness and use of a blood test called hsCRP, which measures inflammation. The goal was to learn what doctors think about inflammation's role in treating patients with heart disease, kidney disease, or heart f…

This study tested whether an augmented reality (AR) tool, accessed via a QR code on a smartphone, could help heart patients better understand their discharge instructions. 303 adults hospitalized for heart attack, heart failure, atrial fibrillation, or pacemaker implantation took…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This study aimed to find the main reasons why people with heart failure come back to the emergency room within 30 days of being discharged. Researchers reviewed the records of 58 adults treated for heart failure to identify key factors. The goal is to use this information to impr…

This study looked at medical records of 4,000 heart failure patients to see if combining routine blood tests (like NT-proBNP) with heart scan results (like fat density around the heart) can better predict who is at risk of dying within a year. The goal is to improve personalized …

This completed study gathered information on 254 Mexican patients with heart failure and reduced ejection fraction. Researchers looked at patient characteristics, treatments, and outcomes in real-world settings. The goal was to understand current medical practices and identify ba…

This study looked at how HeartInsight, a monitoring tool inside heart devices, alerts doctors when heart failure gets worse. About 100 patients with special pacemakers took part. The goal was to see how doctors use these alerts in everyday care to prevent hospital visits.

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to identify different types of heart damage and link them to patient outcomes. No new treatment was tested; instead, researchers aimed to …

This completed study in Greece observed 125 patients with chronic kidney disease (on or off dialysis) or heart failure who were taking sodium zirconium cyclosilicate for high potassium levels. Researchers collected data on patient characteristics and treatment patterns over six m…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study tested a new care plan for heart failure patients admitted to general medicine, who are often Black or Latinx and receive less specialized care. The plan included standard treatments, cardiology checkups, and help with transportation and follow-up. The goal was to see …

This study checked how well German hospitals and heart failure clinics follow recommended treatments for people with a certain type of heart failure (HFrEF) after a serious episode. Researchers looked at the care of 899 patients to see if guidelines were being used. The goal was …

This completed study tested whether a liver ultrasound could detect right-sided heart failure after cardiac surgery. Researchers measured blood flow in the portal vein using Doppler ultrasound in 32 high-risk patients within 24 hours of surgery. The goal was to see if this simple…

This completed study in Greece observed 257 adults with heart failure who were prescribed dapagliflozin as part of their routine care. Researchers tracked how long patients stayed on the drug, any changes in their other heart medications, and how their quality of life changed ove…

This completed study from Novo Nordisk looked at 756 adults in the Middle East who have heart disease with or without kidney disease. Researchers measured levels of a protein called hsCRP, which indicates inflammation throughout the body. Participants had one clinic visit and con…

This study looked at whether using a heart ultrasound during pacemaker implantation helps doctors place the wires more accurately. 33 people with heart failure who needed a pacemaker took part. Researchers measured if the ultrasound reduced procedure time and X-ray use compared t…

This study looked at 18 heart failure patients with a specific heart block to find the best spots for pacing the heart's natural electrical system. Doctors used a 3D mapping system during device implant to see where pacing corrects the heart's rhythm. The goal was to gather infor…

This study looked at how raising ketone levels in the blood affects heart function and sugar use in 41 adults with type 2 diabetes and mild-to-moderate heart failure. Researchers used MRI and PET scans to measure heart pumping and energy use. The goal was to understand the body's…

This completed study looked at how the beta-blocker carvedilol helps the heart pump better in people with heart failure. Fifty-five patients with weak hearts took the highest tolerated dose for six months. Researchers measured changes in heart muscle contraction to understand the…

This completed study from the University of Malaga tested whether motion sensors and 3D cameras can objectively measure movement problems in elderly people with heart failure. 34 participants (healthy and with heart failure) performed functional tasks while wearing a sensor and b…

This study tested whether sending an electronic alert to primary care doctors about patients with high BNP levels (a sign of possible heart strain) would lead to more heart imaging and earlier diagnosis of hidden heart failure. 115 patients with high BNP but no recent heart imagi…

This study looked at whether a breathing device called CPAP can reduce the effort of breathing and improve heart function in children with heart failure. Thirty children aged 8 months to 17 years were monitored during short periods of CPAP and normal breathing. The goal was to un…

This study tested new MRI methods to detect bleeding inside the heart muscle after a heart attack. Researchers studied 14 patients to see if these scans could better identify damage that raises the risk of heart failure. The goal was to improve imaging, not to test a treatment.

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This study looked at reports from the WHO global safety database to see if common heart failure medications are linked to falls in people aged 65 and older. Researchers analyzed over 100,000 records to find which drugs were most often associated with fall reports. The goal is to …