Real-World data shows which heart failure drug may be better
NCT ID NCT07376265
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at health records of 1,249 heart failure patients in Portugal to compare two types of medication: sacubitril/valsartan versus older drugs called ACE inhibitors or ARBs. The goal was to see which treatment better prevents heart failure hospitalizations or death from heart problems. Because this was an observational study using existing data, it reflects real-world care but cannot prove cause and effect.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sacubitril/valsartan (a combination drug) compared to ACE inhibitors or ARBs (standard heart failure medications)
What this could lead to
If results are positive, this could support using sacubitril/valsartan as a preferred treatment to reduce heart failure hospitalizations and cardiovascular death.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by unmeasured factors. It also only looked at a specific population in Portugal, so findings may not apply everywhere.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Novartis
East Hanover, New Jersey, 07936, United States