HEART FAILURE

This study is testing a mobile app designed to help people with heart failure better manage their condition. The app tracks health status, vital signs, weight, and medications, and shares this information with doctors. Researchers want to see if using this app helps patients get …

This study is testing whether placing a pacemaker wire in a specific, late-activating area of the heart is better than standard placement for people with heart failure and a specific electrical problem (bundle branch block). It involves 1,000 participants who are getting a specia…

This study is testing a new, minimally invasive heart procedure that creates a small opening between the upper chambers of the heart. The goal is to relieve pressure and reduce the number of times patients with heart failure need to go to the hospital. Researchers will compare th…

This early-stage study is testing whether modified immune cells can help people with severe heart failure. Researchers take patients' own immune cells, engineer them to target scar tissue in the heart, and then return them to the body. The main goal is to check if this approach i…

This study is testing whether a dietary supplement called a ketone ester can improve heart function in people with heart failure. Fifty participants will be randomly assigned to receive either the supplement or a placebo for 12 weeks. Doctors will use heart MRI scans to measure c…

This study analyzes existing health insurance records to compare two common type 2 diabetes medications, oral semaglutide and sitagliptin. It aims to see which drug is more effective at preventing serious heart failure complications, like hospitalization, in people who have both …

This study is testing whether an automated computer alert can help doctors prescribe the recommended medications for people with heart failure. The alert pops up in patients' electronic health records when they visit their cardiologist. Researchers want to see if this reminder sy…

This study is testing whether adding a traditional Japanese herbal medicine called Goreisan to standard heart failure treatment helps reduce dangerous fluid buildup better than standard treatment alone. The trial involves about 1,200 adults hospitalized with worsening heart failu…

This early study is testing a small, temporary heart pump called the Impella BTR in 10 adults with severe, worsening heart failure. The pump is surgically placed to help the heart pump blood while patients recover or wait for their next treatment. Researchers want to see if the d…

This study looks back at medical records to see if a specific class of heart failure drugs (SGLT2 inhibitors) helps improve blood cell production and, in turn, benefits heart and kidney health. It compares 85 patients who took these drugs to similar patients who did not, tracking…

This trial is testing a small, permanently implanted device called the Corvia Atrial Shunt. It is designed for people with a specific type of heart failure where the heart pumps normally but is too stiff to fill properly. The device creates a small opening between the heart's upp…

This study is testing the safety and performance of a new pacemaker system (Amvia pacemaker with Solia CSP S lead) for people who need heart rhythm treatment. The research involves 152 participants in Europe, Australia, and New Zealand who will be followed for up to 12 months aft…

This study is testing if a home-based exercise program using spot-jogging (jogging in place) is as effective as traditional outpatient center rehab for people with heart failure. It involves 40 participants who will be randomly assigned to either do their exercises at home or at …

This study is testing if a newer diabetes medication called tirzepatide can improve heart function and overall health in people who have both chronic heart failure and type 2 diabetes. 120 adults in Kazakhstan will receive the drug and be closely monitored for 40 weeks. Researche…

This study compares two diabetes medications, tirzepatide and semaglutide, to see which works better at preventing heart failure hospitalizations and death in people who have both type 2 diabetes and a specific type of heart failure. Researchers will follow 26,000 patients using …

This study is testing a new type of wire (lead) for heart devices like defibrillators. The lead is designed to deliver electrical therapy more precisely to control dangerous irregular heartbeats in people with heart failure. Researchers are checking if this new lead is safe and w…

This study is testing whether a medication called Finerenone can improve the structure of the heart in people who have both diabetic kidney disease and a specific type of heart failure. Researchers will give 40 participants the drug for six months and use advanced heart scans to …

This early study is testing a new device called the Edwards APTURE Transcatheter Shunt System. It is designed to be implanted in the heart to help relieve pressure for people with symptomatic heart failure. The main goal is to see if the device is safe and works as intended in th…

This study is testing if a specific treatment plan for water pills (diuretics), guided by a simple urine sodium test, works better than standard emergency room care for people with sudden worsening of heart failure. About 474 patients will be randomly assigned to get either the n…

This study is testing whether providing hospital-level medical care in a patient's own home is a safe and effective alternative to a traditional hospital stay. It will involve nearly 10,000 adults with conditions like heart failure, infections, or COPD who qualify for hospital ad…

This study is testing a 16-week program that uses a smartphone app, nurse home visits, and family support to help people with advanced heart failure manage their condition after leaving the hospital. It aims to improve patients' quality of life and self-care skills, with the goal…

This early-stage study is testing whether injecting lab-grown heart muscle cells into the heart during bypass surgery is safe and might help people with severe heart failure. The cells, made from stem cells, are given to up to 36 patients who are already having heart surgery. The…

This study is trying to find the best type of heart procedure for people who have both a long-lasting irregular heartbeat (persistent atrial fibrillation) and heart failure. It will compare different techniques for a procedure called catheter ablation to see which one is most eff…

This study aims to understand exactly how the medication vericiguat helps people with chronic heart failure. Researchers will test 30 patients to see if the drug improves how the heart and blood vessels work, especially during exercise. Participants will take either the real drug…

This trial is testing a new device called the Edwards EVOQUE system, which is implanted via a catheter to replace a leaky tricuspid heart valve. It aims to see if this implant, along with standard medication, is safer and more effective than medication alone for patients with sev…

This study is testing a new driving system for a heart pump designed to help children with severe heart failure. The pump supports the child's heart while they wait for a transplant. Researchers will monitor how well the new system works and how safe it is for up to 40 children w…

This study is testing a device called the Alleviant System. It creates a tiny opening between the upper chambers of the heart to relieve pressure, but doesn't leave a permanent implant behind. The goal is to see if this procedure is safe and can help 500 people with a specific ty…

This early-stage study is testing whether transplanting tiny balls of lab-grown heart muscle cells (made from stem cells) is safe and can help patients with severe heart failure. Ten patients with heart failure caused by poor blood flow to the heart will receive the cell transpla…

This study is testing a catheter-based procedure to replace failing artificial mitral heart valves. It involves 53 patients who have symptoms like shortness of breath due to their old valve not working properly. Doctors are checking if this less invasive approach is safe and help…

This study is testing a new temporary heart pump device called the Supira System. It's designed to help support patients' blood pressure and heart function during complex, high-risk procedures to open blocked heart arteries. The research aims to see if the device is safe and work…

This study is collecting real-world information from 5,000 people with heart failure who have already received the Barostim device. The goal is to understand the long-term safety and benefits of the device in everyday use. Researchers will track patients' health for up to three y…

This study is checking if changes to how replacement heart valves are made and packaged are safe and work well. It involves 777 adults who need to replace a damaged aortic or mitral valve. Researchers will follow participants for up to 5 years to see how the valves hold up and if…

This study aims to improve how veterans with heart failure get their medications managed. It tests whether giving pharmacists extra education and feedback, and nudging primary care doctors to refer patients, leads to more frequent and better medication adjustments. The project in…

This study is testing if a medication called empagliflozin can help people with hypertrophic cardiomyopathy (HCM), a genetic condition that thickens the heart muscle and can lead to heart failure. For 12 months, 250 adult patients without diabetes will take either the drug or a p…

This study is testing whether adding video call education to standard heart failure training helps patients better manage their condition. Researchers will compare 100 patients who receive either standard education alone or standard education plus video call follow-ups. The goal …

This study compares two approaches for treating completely blocked heart arteries: performing a stent-opening procedure plus medication versus using medication alone. It involves 2000 people with stable heart disease who have symptoms like chest pain or shortness of breath. Resea…

This study compares two types of blood thinners for treating dangerous blood clots inside the heart. It tests whether newer, easier-to-use medications (DOACs) work as well or better than the older standard (warfarin) at dissolving clots and preventing strokes or death. The trial …

This study is testing if a drug called dapagliflozin, already used for other types of heart failure, can help adults born with a Fontan circulation. The goal is to see if the drug can reduce dangerous fluid pressure in their veins and improve their ability to exercise and feel be…

This trial is testing a small, implanted device called the APTURE shunt to see if it helps people with certain types of heart failure who still feel poorly despite taking the best available medications. About 100 participants will be randomly assigned to receive either the real s…

This study is checking the long-term safety and real-world performance of an implanted heart device called the OPTIMIZER Smart. It involves 620 adults with moderate heart failure who are receiving the device as part of their standard care. The main goal is to see how safe the dev…

This study is testing a new, minimally invasive device called the APTURE shunt in people with heart failure. The device is implanted to create a small opening between heart chambers, aiming to safely reduce high blood pressure in the lungs and heart. Researchers will check if the…

This study is checking how well a special feature in some heart devices works in everyday life. The feature tries to warn doctors when a heart failure patient is at high risk of getting sicker. Researchers are watching 2,200 patients with these devices to see if the warnings are …

This study is testing a new device that scans a person's feet daily to detect early signs of fluid buildup, a common warning of worsening heart failure. The goal is to see if this automatic monitoring can help patients and doctors act sooner to adjust treatment, potentially preve…

This study is testing whether using a special breathing machine at night for six months can improve how the heart uses energy and how its nerves function in people who have both heart failure and sleep apnea. Researchers will use advanced heart scans to measure changes in 60 part…

This small pilot study is testing whether counseling patients with heart failure to follow the DASH diet helps improve their eating habits, symptoms, and key health markers like blood pressure. Researchers are working with 26 stable heart failure patients in an outpatient clinic …

This study is testing whether professional dental cleaning for gum disease (periodontitis) can help control heart failure. Researchers will measure a key blood marker of heart failure in about 80 adults with both conditions over 6 months. The goal is to see if treating the gums i…

This study is testing whether sending official digital letters can help more people with heart failure start taking a recommended medication called an SGLT-2 inhibitor. The goal is to get eligible patients on this treatment faster than the current process allows. Researchers are …

This large international study aims to improve treatment for people receiving heart devices like pacemakers. Researchers want to identify which patients are most at risk of developing heart damage from their devices before implantation happens. By creating a personalized risk sco…

This study is testing a new type of heart device called the CorSky ICD family for the first time in people. It aims to check if the device is safe and works properly in 52 patients with dangerous fast heart rhythms or heart failure who need an implantable defibrillator. Participa…

This large, long-term study is analyzing health records to see if effectively treating both obstructive sleep apnea and high blood pressure can prevent serious heart problems or death. It will follow 10,000 patients to compare outcomes between those who use their sleep apnea mach…

This study tested whether gently stimulating a nerve in the neck (the vagus nerve) could help improve the heart's structure and function in people with moderate to severe heart failure. It involved 118 participants who had a weakened heart muscle. The goal was to see if this nerv…

This study is testing whether a 9-month program to increase daily steps can improve walking ability and reduce symptoms in people with heart failure. Researchers will compare the step program, which uses wearable devices and online coaching, to standard medical care alone. The go…

This study is testing whether it is safe and practical for heart failure patients to receive a special pacemaker and be discharged from the hospital on the same day. It compares outcomes for patients in a same-day program against those who stay in the hospital overnight as usual.…

This large study is testing whether the drug dapagliflozin can help protect the heart and kidneys in people with very severe chronic kidney disease, including those on dialysis or with a kidney transplant. About 1,750 participants will take either dapagliflozin or a placebo daily…

This study is testing whether a small, implanted heart monitor can find hidden, irregular heartbeats (atrial fibrillation) in people with heart failure. Finding these rhythm problems early could allow doctors to start treatments like blood thinners to prevent strokes and hospital…

This study is testing a new, easy-to-use finger sensor that aims to help doctors and patients detect heart failure earlier. The sensor, inspired by Traditional Chinese Medicine pulse reading, uses artificial intelligence to analyze pulse patterns. Researchers are collecting pulse…

This study aims to find a simpler way to screen for heart failure in people with pacemakers. Researchers will test if a quick, AI-guided handheld heart scan or a simple finger-prick blood test can be as accurate as a longer, expert-led ultrasound. The goal is to make screening fa…

This study is testing whether a simple blood test can help doctors find heart failure earlier in people who take common water pills (like furosemide) but haven't been diagnosed with the condition. Researchers will enroll 400 adults from primary care clinics, randomly assigning wh…

This study is testing a new wearable sensor that estimates how well the heart is pumping blood, a key measure called ejection fraction. The goal is to see if the sensor's readings match those from a standard heart ultrasound. The study will enroll 50 people who are already schedu…

This study is testing whether a smartphone app can detect worsening heart failure by analyzing changes in a person's daily voice recordings. 123 patients who were recently hospitalized for heart failure will use the app at home for six months. The goal is to see if the app can sp…

This study is testing a specific screening method to find undiagnosed heart failure in people with diabetes who are at high risk. About 700 participants are being randomly assigned to either receive this new screening or continue with their usual care. The screening involves a bl…

This study is testing a training program to teach family doctors how to use a focused heart ultrasound. The goal is to see if these trained doctors can accurately spot common heart issues during regular check-ups, which could help patients get diagnosed faster without waiting mon…

This study is testing if sending specially prepared meals to the homes of people recently hospitalized for heart failure is a practical and helpful part of their recovery. Researchers will enroll about 85 patients to receive 4 or 8 weeks of delivered meals and ask them about thei…

This study aims to see if carefully stopping beta-blocker medication helps older adults with a specific type of heart failure (HFpEF) feel better and improve their daily life. About 240 participants will be randomly assigned to either gradually stop their beta-blocker or continue…

This study is testing whether a combination of virtual reality exercises and computer-based brain training can improve memory, attention, and daily life skills in older adults who have both heart failure and mild thinking problems. Researchers will compare the combined approach t…

This study aimed to see if adding game-like challenges to a patient's daily step goals could help them be more active while in the hospital. It planned to use wearable devices and text messages with older adults who had heart or metabolic conditions. The goal was to see if more w…

This study is testing if a team-based clinic can improve the daily life and physical function of people living with a mechanical heart pump (VAD). It will involve 110 patients and their caregivers, comparing new team care to standard visits. The goal is to see if this approach le…

This study is testing whether a supervised exercise and diet education program can help cancer survivors who have developed heart failure. Researchers are comparing this program to standard care to see if it improves symptoms and quality of life. The study involves 85 participant…

This study aims to understand how heart failure affects balance and thinking skills like memory and focus in middle-aged and older adults. Researchers will compare 60 heart failure patients to a healthy group, measuring their abilities at the hospital and tracking changes one and…

This study aims to understand if there are racial differences in heart failure biomarkers between African American and Caucasian patients. Researchers will compare blood test results from 400 patients newly diagnosed with heart failure to see if biomarker levels differ between ra…

This study aims to learn how SGLT2 inhibitor medications, which are already FDA-approved for heart failure, affect the body. Researchers will observe 40 patients with symptomatic heart failure who are starting this medication. They will measure changes in blood chemistry, walking…

This study is monitoring the long-term safety and performance of a specific heart device lead (Model 4798) in over 1,000 patients with heart failure. It's a required follow-up study by the FDA after the device's initial approval. Researchers are tracking patients for five years t…

This study aims to use advanced heart scans to better understand early heart failure in people with conditions like diabetes, high blood pressure, or obesity. It will enroll 3,000 participants who have these risk factors but whose hearts still pump normally. The goal is to find p…

This study is testing if a simple, non-invasive scan of the back of the eye (the retina) can help doctors understand how severe a person's heart failure is. Researchers will take pictures of the eyes of 250 people with heart failure to see if changes in the tiny blood vessels the…

This study aims to understand why people with heart failure often lose muscle mass and strength, a condition called sarcopenia. Researchers will study 80 participants, comparing those with heart failure to healthy individuals. They will use blood tests, body scans, and fitness as…

This study aims to understand how common heart disease and its risk factors are among adults in Port-au-Prince, Haiti. Researchers will follow about 3,000 people for several years, tracking their health, lifestyle, and diet. The goal is to gather information to help plan better h…

This study is testing whether a special type of heart scan, called T1 mapping, can accurately detect heart disease and predict patient outcomes like survival and hospitalization. It will enroll 8,000 adults who are already scheduled for a heart scan for medical reasons. The goal …

This study looks at a serious complication called acute hemodynamic instability (AHI), which is a dangerous drop in blood pressure, after a minimally invasive heart valve replacement. Researchers will review medical records of 140 high-risk heart failure patients who were too sic…

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This study is testing a personalized approach to help older adults with a common type of heart failure decide whether to continue taking their beta-blocker medication. Researchers will work with 20 participants, having each person try periods on and off their prescribed beta-bloc…

This study is testing a new digital platform designed to improve how patient information is shared when someone is transferred between different hospitals. The goal is to make sure doctors at the receiving hospital have all the necessary details to provide safe, continuous care. …

This study is testing a new AI voice assistant tool to see if it can reliably collect health updates from people with heart failure. The goal is to see if talking to an AI can be an easy and accurate way for patients to share symptoms and vital signs with their care team. About 1…

This study aims to collect data from small implanted heart monitors to help design better tools for detecting when heart failure is getting worse. It involves 525 adults with moderate heart failure who agree to have the monitor implanted and use a related phone app. The goal is t…

This study aims to see if advanced heart scans can predict which patients newly diagnosed with weakened heart function are likely to recover. Researchers will use multiple imaging tests on 180 participants to understand the disease better and identify patterns of recovery. The go…

This study aimed to develop a computer program that could predict how long patients would need to stay in home hospital care. Researchers used existing patient records to train the program, then tested it on different patient groups. The goal was to help hospitals better plan car…

This study aimed to understand how the heart muscle changes shape and size after a heart attack. Researchers followed 1,599 people from specific Minnesota counties who had a recent heart attack. The goal was to learn which patterns of heart change are linked to developing heart f…

This small study aims to understand if people with a specific genetic variation that lowers a certain enzyme (DPP4) respond differently to the diabetes drug sitagliptin. Twenty participants, half with the gene variant and half without, will take the drug and a placebo for short p…

This study aims to find better ways for doctors to talk with seriously ill patients about their end-of-life care preferences. It will test different communication strategies with 5,000 Duke Health patients who have conditions like cancer, heart failure, COPD, or dementia. The goa…

This study aims to better understand heart failure by collecting blood samples and health data from 2000 adults who already have the condition. Researchers will analyze the samples to look for proteins and other biological markers that might explain why heart function declines ov…

This study aims to understand how arm and shoulder strength and function relate to hospital visits and overall health in people with heart failure who have an implanted heart device like a defibrillator. Researchers will measure participants' arm strength, endurance, and ability …

This study is observing 3,030 heart failure patients who already have or are getting a special heart device called CRT. Researchers are tracking their health outcomes over time through remote monitoring to understand how well these devices work in everyday life. The goal is to id…

This study is a nationwide registry in Poland that aims to learn more about two specific types of heart failure. It will observe 700 patients to collect detailed information about their health, treatments, and outcomes over time. The goal is to better understand these conditions …

This study aims to understand how the drug dapagliflozin is used for heart failure in real-world medical settings in Germany. It will observe 765 patients who have recently started taking the drug to see how long they stay on it, if their symptoms and quality of life improve, and…

This study is testing whether a smartphone app called StudyU can help older adults with a specific type of heart failure (HFrEF) safely reach their recommended beta blocker dose. It's a small pilot study with just 5 participants, focusing on whether using the app for personalized…

This study has two main goals. First, it tests whether using shorter, simpler permission forms makes more people willing to join a research project. Second, it tests a new support program that offers money, a coach, and text messages to help patients attend a recommended heart re…

This study aims to help doctors predict which heart failure patients will benefit most from a special pacemaker called CRT. Researchers will analyze blood samples taken during the device implantation surgery from 65 patients with severe heart failure. The goal is to find markers …