Lab-Grown heart cells implanted in 10 patients in bid to repair damaged hearts

NCT ID NCT04945018

Ongoing Disease control Sponsor: Heartseed Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This early-phase trial is testing whether heart muscle cells grown from stem cells can be safely injected into the hearts of 10 people with severe heart failure caused by blocked arteries. The main goal is to check for side effects over 26 weeks, while also measuring whether the treatment improves the heart's pumping ability. If successful, it could lead to larger studies exploring a new repair strategy for failing hearts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: iPS cell-derived heart muscle cells (HS-001)
What this could lead to: If it works, this could point toward a new way to repair damaged heart muscle in people with severe heart failure, potentially reducing the need for a heart transplant.
What could go wrong: This is a very early, small trial with only 10 participants, so results may not apply to everyone. There are risks from the injection procedure and the cells themselves, such as irregular heartbeats or rejection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE ISCHEMIC HEART DISEASE

Contacts and locations

Locations

Juntendo University Hospital

Tokyo, Japan
Nihon University Itabashi Hospital

Tokyo, Japan
Saitama Medical University International Medical Center

Saitama, Japan
St. Marianna University Hospital

Kawasaki, Japan
The University of Tokyo Hospital

Tokyo, Japan
Tokyo Medical and Dental University Medical Hospital

Tokyo, Japan
Tokyo Metropolitan Geriatric Medical Center

Tokyo, Japan
Tokyo Women's Medical University

Tokyo, Japan

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