Urine-Guided diuretic dosing could revolutionize ER heart failure care
NCT ID NCT04481919
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This study tests whether using urine sodium levels to guide diuretic dosing improves outcomes for emergency department patients with acute heart failure. About 474 adults with fluid overload will be randomly assigned to either the urine-guided protocol or standard care. The goal is to see if this personalized approach leads to better clinical status and less congestion.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- diuretic therapy (furosemide or similar) guided by urine sodium levels
- What this could lead to
- If successful, this could provide a more effective way to manage fluid overload in acute heart failure, reducing hospital stays and improving recovery.
- What could go wrong
- This is a Phase 2 trial with 474 participants, so results are preliminary. The protocol may not outperform standard care, and diuretics carry risks like kidney strain or electrolyte imbalances.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACUTE HEART FAILURE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
VA Tennessee Valley Health Service
Nashville, Tennessee, 37232, United States
-
Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a second diuretic boost recovery from heart failure?
- Digital nurse companion: could an app ease the burden of chronic illness?
- Could continuing a common heart drug before surgery save lives?
- Poles apart? nordic walking may outpace standard rehab for heart failure
- Could a gentler tug on the Heart's reins spark recovery?
- Can slow breathing soothe a failing heart?