New heart pacing strategy could cut defibrillator need

NCT ID NCT05572957

Ongoing Disease control Sponsor: The First Affiliated Hospital with Nanjing Medical University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a special heart pacing technique (left bundle branch pacing) combined with standard heart failure drugs can improve heart function better than drugs alone. It includes 50 adults with non-ischemic heart failure and a specific heart block. The main goal is to see if this combination reduces the number of patients who need a defibrillator implant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: left bundle branch pacing (a heart pacing procedure) combined with guideline-directed medical therapy (a set of heart failure drugs)
What this could lead to: If it works, this approach could reduce the need for implantable defibrillators in heart failure patients, offering a less invasive option.
What could go wrong: This is a small, early-phase study with only 50 participants, so results may not apply to everyone. The pacing procedure also carries risks like infection or lead displacement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure intrinsic cardiomyopathy progressive familial heart block, type 1A systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE LEFT BUNDLE-BRANCH BLOCK NON-ISCHEMIC CARDIOMYOPATHY

Contacts and locations

Locations

Fujian Medical University Union Hospital

Fuzhou, Fujian, China
Fuwai Hospital, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China
The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China
The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China
The First Affiliated Hospital with Nanjing Medical University

Nanjing, Jiangsu, 210029, China
West China Hospital, Sichuan University

Chengdu, Sichuan, China

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