Beating heart machine for transplants under Real-World watch

NCT ID NCT05047068

Ongoing Disease control Sponsor: TransMedics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This registry follows 350 adult heart transplant patients whose donor hearts were kept alive and beating using the OCS Heart System before transplant. The goal is to see how well patients do one year after surgery. The device may allow more donor hearts to be used, especially those that would otherwise be rejected for cold storage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

OCS Heart System (device for preserving donor hearts outside the body)

What this could lead to

If successful, this registry could confirm that the OCS Heart System helps more donor hearts be safely used for transplant, potentially saving more lives.

What could go wrong

This is an observational registry, not a controlled trial, so it cannot prove the device is better than standard cold storage. Results may not apply to all transplant centers.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

heart failure transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRANSPLANT

Contacts and locations

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Locations

Baylor Scott and White

Dallas, Texas, 75226, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Cedars Sinai

Los Angeles, California, 90048, United States
Columbia University Irving Medical Center/ New York Presbyterian Hospital

New York, New York, 10032, United States
Duke University

Durham, North Carolina, 27710, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Froedtert & the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Medical City Dallas

Dallas, Texas, 75230, United States
Methodist Hospital

San Antonio, Texas, 78229, United States
Minneapolis Heart Institute

Minneapolis, Minnesota, 55407, United States
Montefiore

The Bronx, New York, 10467, United States
Northwestern Medicine

Chicago, Illinois, 60611, United States
Stanford University

Palo Alto, California, 94304, United States
Tampa General Hospital

Tampa, Florida, 33606, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
University of California San Francisco

San Francisco, California, 94143, United States
University of Kentucky

Lexington, Kentucky, 40506, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Minnesota

Minneapolis, Minnesota, 55414, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Washington Medical Center

Seattle, Washington, 98105, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37212, United States
Westchester Medical Center

Valhalla, New York, 10595, United States
Yale New Haven Hospital

New Haven, Connecticut, 06510, United States