Could a simple shot replace the IV for heart failure fluid removal?

NCT ID NCT06167707

Completed Knowledge-focused Sponsor: scPharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tested a new version of the water pill furosemide that can be injected under the skin (subcutaneous) using an autoinjector, comparing it to the standard IV form given in a hospital. The study involved 21 healthy volunteers aged 45 to 80 to see how the drug is absorbed and how much urine it produces. The goal is to see if this easier method could one day help heart failure patients manage fluid buildup at home.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Furosemide (a water pill)
What this could lead to: If successful, this could lead to a convenient way for heart failure patients to receive furosemide at home via a simple injection under the skin, instead of needing an IV in a hospital.
What could go wrong: This is a very early Phase 1 study in only 21 healthy people, not heart failure patients. It is designed to measure drug levels and safety, not to prove it works for treating fluid overload. The results may not apply to actual patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Edema heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FLUID OVERLOAD HEART FAILURE

Contacts and locations

Locations

Elixia EPCT, LLC

Tampa, Florida, 33618, United States

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