New device could keep donor hearts alive longer for transplant

NCT ID NCT06895070

Recruiting now Disease control Sponsor: XVIVO Perfusion Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a device that keeps donor hearts functioning outside the body without stopping blood flow. It aims to safely use hearts from extended-criteria donors (e.g., older or with other health issues) for transplant. Sixty adult heart transplant recipients will receive a heart preserved this way, and researchers will check survival and success at 30 days and one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Non-Ischemic Heart Preservation (NIHP) using the XVIVO Heart Preservation System (XHPS) – a device that keeps donor hearts functioning outside the body
What this could lead to: If successful, this could allow more donor hearts to be used for transplant, helping people with heart failure get a new heart sooner.
What could go wrong: This is an early-stage study with only 60 participants, so results may not apply to everyone. The device is new, and there could be unforeseen risks during preservation or transplant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE HEART TRANSPLANT TRANSPLANT; FAILURE, HEART

Contacts and locations

Locations

Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Columbia University Medical Center/New York Presbyterian Hospital
RECRUITING

New York, New York, 10032, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
NYU Langone
RECRUITING

New York, New York, 10016, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611-5969, United States
Stanford University
RECRUITING

Stanford, California, 94305, United States
UC San Diego Health
RECRUITING

La Jolla, California, 92037, United States
University of California Los Angeles
RECRUITING

Los Angeles, California, 90095-1405, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 69198-2265, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University - Barnes Jewish Health Hospital
RECRUITING

St Louis, Missouri, 63110, United States

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