New imaging technique could predict success of CAR T-Cell therapy in lymphoma patients
NCT ID NCT05404048
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This pilot study tests a new PET imaging method using a tracer called 89Zr-atezolizumab to see if it can predict how well patients with large B-cell lymphoma respond to CAR T-cell therapy. The study involves 20 participants and aims to determine if this imaging can also tell the difference between active lymphoma and inflammation caused by treatment. The goal is to improve treatment decisions and outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
89Zr-atezolizumab (a radioactive tracer for PET imaging)
What this could lead to
If successful, this imaging method could help doctors predict which patients will respond to CAR T-cell therapy and avoid unnecessary treatments.
What could go wrong
This is a small pilot study with only 20 participants, so results may not apply to everyone. The imaging technique is experimental and may not reliably distinguish lymphoma from inflammation.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University Medical Center Groningen
Groningen, 9713GZ, Netherlands