New combo aims to boost lymphoma control in older patients
NCT ID NCT05820841
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This phase 3 trial investigates whether adding the targeted drug acalabrutinib to a reduced-dose chemotherapy regimen (R-miniCHOP) helps older adults with untreated diffuse large B-cell lymphoma live longer without their cancer progressing. Participants are randomly assigned to receive either standard R-miniCHOP alone or R-miniCHOP plus acalabrutinib. The study focuses on patients aged 70 and older, a group often underserved in cancer research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
acalabrutinib
What this could lead to
If it works, this could improve the chance of keeping the lymphoma from returning in older patients who often cannot tolerate full-dose chemotherapy.
What could go wrong
This is an early-phase 3 trial, so results are not yet known. Adding acalabrutinib may increase side effects without improving outcomes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brüderkrankenhaus St. Josef
NOT_YET_RECRUITINGPaderborn, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Bundeswehrkrankenhaus Ulm
NOT_YET_RECRUITINGUlm, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CaritasKlinikum Saarbrücken St. Theresia
RECRUITINGSaarbrücken, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gemeinschaftspraxis Mohm/Prange-Krex
NOT_YET_RECRUITINGDresden, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Helios Klinikum Emil von Behring
RECRUITINGBerlin, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johannes Wesling Klinikum
NOT_YET_RECRUITINGMinden, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum Mutterhaus der Borromäerinnen
RECRUITINGTrier, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Krankenhaus der Barmherzigen Brüder Trier
NOT_YET_RECRUITINGTrier, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MVZ am Klinikum Aschaffenburg
NOT_YET_RECRUITINGAschaffenburg, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Onkologische Schwerpunktpraxis Kurfürstendamm
NOT_YET_RECRUITINGBerlin, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rheinland Klinikum-Lukaskrankenhaus Neuss
NOT_YET_RECRUITINGNeuss, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Saarland University Medical Center
RECRUITINGHomburg, Saarland, 66421, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Städtisches Klinikum Karlsruhe
RECRUITINGKarlsruhe, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Gießen und Marburg, Standort Gießen
RECRUITINGGiessen, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Ulm
RECRUITINGUlm, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsmedizin Greifswald
RECRUITINGGreifswald, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsmedizin Halle (Saale)
RECRUITINGHalle, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••