New combo aims to boost lymphoma control in older patients

NCT ID NCT05820841

Recruiting now Disease control Sponsor: Universität des Saarlandes Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This phase 3 trial investigates whether adding the targeted drug acalabrutinib to a reduced-dose chemotherapy regimen (R-miniCHOP) helps older adults with untreated diffuse large B-cell lymphoma live longer without their cancer progressing. Participants are randomly assigned to receive either standard R-miniCHOP alone or R-miniCHOP plus acalabrutinib. The study focuses on patients aged 70 and older, a group often underserved in cancer research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acalabrutinib
What this could lead to: If it works, this could improve the chance of keeping the lymphoma from returning in older patients who often cannot tolerate full-dose chemotherapy.
What could go wrong: This is an early-phase 3 trial, so results are not yet known. Adding acalabrutinib may increase side effects without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B-CELL LYMPHOMA LARGE B-CELL LYMPHOMA

Contacts and locations

Locations

Brüderkrankenhaus St. Josef
NOT_YET_RECRUITING

Paderborn, Germany
Bundeswehrkrankenhaus Ulm
NOT_YET_RECRUITING

Ulm, Germany
CaritasKlinikum Saarbrücken St. Theresia
RECRUITING

Saarbrücken, Germany
Gemeinschaftspraxis Mohm/Prange-Krex
NOT_YET_RECRUITING

Dresden, Germany
Helios Klinikum Emil von Behring
RECRUITING

Berlin, Germany
Johannes Wesling Klinikum
NOT_YET_RECRUITING

Minden, Germany
Klinikum Mutterhaus der Borromäerinnen
RECRUITING

Trier, Germany
Krankenhaus der Barmherzigen Brüder Trier
NOT_YET_RECRUITING

Trier, Germany
MVZ am Klinikum Aschaffenburg
NOT_YET_RECRUITING

Aschaffenburg, Germany
Onkologische Schwerpunktpraxis Kurfürstendamm
NOT_YET_RECRUITING

Berlin, Germany
Rheinland Klinikum-Lukaskrankenhaus Neuss
NOT_YET_RECRUITING

Neuss, Germany
Saarland University Medical Center
RECRUITING

Homburg, Saarland, 66421, Germany
Städtisches Klinikum Karlsruhe
RECRUITING

Karlsruhe, Germany
Universitätsklinikum Gießen und Marburg, Standort Gießen
RECRUITING

Giessen, Germany
Universitätsklinikum Ulm
RECRUITING

Ulm, Germany
Universitätsmedizin Greifswald
RECRUITING

Greifswald, Germany
Universitätsmedizin Halle (Saale)
RECRUITING

Halle, Germany

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