Can more proton radiation beat lung cancer safely?

NCT ID NCT06484491

Recruiting now Disease control Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether giving a higher dose of proton therapy to the lung tumor is safe for people with stage III non-small-cell lung cancer who are also getting chemotherapy. About 87 participants will receive the higher radiation dose along with standard chemo drugs. Researchers will monitor for severe side effects needing hospital care and check how well the treatment controls the tumor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton therapy (radiation) plus cisplatin or carboplatin with pemetrexed and docetaxel (chemotherapy)
What this could lead to: If successful, this could show that a higher dose of proton therapy is safe and may improve tumor control for people with advanced lung cancer.
What could go wrong: This is a small early pilot study with only 87 participants, so results may not apply to everyone. There is a risk of severe side effects from the higher radiation dose.

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

UMCG
RECRUITING

Groningen, Netherlands

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