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Beyond TB: could a deeper diagnostic look uncover hidden lung diseases?

NCT ID NCT06737029

Diagnosis Sponsor: Stichting Longartsen voor Afrika Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This study tests whether an enhanced diagnostic workup can identify lung diseases other than tuberculosis in patients who are about to start TB treatment based on clinical signs but have negative sputum tests. Participants will undergo a thorough review and possibly additional tests like blood work, lung function tests, CT scans, or bronchoscopy. The goal is to see if these extra investigations lead to a more accurate diagnosis at six months, potentially improving treatment and outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Enhanced diagnostic workup including detailed review, blood tests, spirometry, chest CT, repeat X-ray, sputum tests, or bronchoscopy
What this could lead to
If successful, this could improve diagnosis and management for patients with suspected TB, ensuring they receive the right treatment for their actual condition.
What could go wrong
The trial is relatively small and observational in nature, so results may not apply broadly. Additional tests may be invasive or carry risks, and the diagnostic accuracy may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

311 people

The number who actually took part.

Started

Dec 2024

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All adult patients who have a negative initial GeneXpert MTB/RIF test on sputum, but are about to start standard first-line treatment for suspected pulmonary tuberculosis on clinical grounds (i.e. empiric tuberculosis treatment), at four first-level Hospitals in Lusaka, Zambia. Patients will be excluded if they are inpatients (due to suspected tuberculosis), or are unable to visit the central study site for additional review or investigations.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult patient * about to start TB treatment for suspected pulmonary tuberculosis, but with sputum GeneXpert negative Exclusion Criteria: * suspected drug-resistant tuberculosis * inpatient (because of suspected tuberculosis) * unable to visit central study site for review or additional investigations

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Conditions

The condition(s) this trial relates to.

lung disorder pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung diseases Tuberculosis

Contacts and locations

Locations

  • University Teaching Hospital

    Lusaka, Lusaka Province, Zambia

More trials for these conditions

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