TUBERCULOSIS

This early-stage trial tested the safety of two new tuberculosis vaccine candidates in healthy adults who had never received the standard BCG vaccine. Researchers gave 120 participants different dose levels of the experimental vaccines or a placebo to check for side effects and i…

This study aimed to understand how the body processes two tuberculosis drugs, rifapentine and moxifloxacin, when given at high doses. Researchers measured drug levels in the blood of 53 adult TB patients to see if higher drug exposure led to better treatment results and fewer sid…

This study tested a new tuberculosis drug, GSK3036656, in different two-drug combinations for 14 days. It involved 127 adults with newly diagnosed, drug-sensitive lung TB. The main goal was to see how quickly these combinations could kill the TB bacteria in sputum and to check th…

This study tested a new approach to find tuberculosis (TB) in young children hospitalized with severe pneumonia in six high-risk countries. Researchers wanted to see if using a fast, sensitive test on easy-to-collect samples (like nasal fluid and stool) right when a child arrives…

This study tested whether eating cookies fortified with zinc and selenium could help improve the immune system and health outcomes for people being treated for tuberculosis. Researchers gave specially baked cookies with different amounts of these minerals to 90 tuberculosis patie…

This study aimed to find safe and effective doses of the drug bedaquiline for children and adolescents with a hard-to-treat form of tuberculosis (TB) that resists standard antibiotics. It involved 54 young people, from infants to teens, some also living with HIV. Researchers care…

This study tested whether adding treatments for tuberculosis (TB) and a common virus called cytomegalovirus (CMV) to standard pneumonia care could help more HIV-infected infants survive severe pneumonia. It involved 563 hospitalized babies aged 1-12 months across six African coun…

This study tested two different approaches to prevent tuberculosis (TB) in Malaysian prisons, where many inmates have opioid addiction, HIV, or hepatitis. Researchers compared a standard 40-week daily treatment against a shorter 12-week weekly treatment to see which worked better…

This study tested whether adding the common diabetes medication metformin to standard antibiotic treatment for tuberculosis (TB) is safe and helps people recover better, especially for those also living with HIV. Researchers wanted to see if metformin could help clear the TB infe…

This large Phase 3 trial tested whether a stronger, intensified tuberculosis (TB) treatment regimen could save more lives than standard TB treatment in HIV patients hospitalized with TB and severely weakened immune systems (CD4 ≤ 100 cells/μL). It enrolled 1,330 adults and adoles…

This study tested whether a smartphone app called Hyfe Cough Tracker could help monitor and manage coughs in people with various respiratory diseases. Over 600 participants with conditions like COPD, asthma, or COVID-19 used the app to record their coughs for up to 30 days. Resea…

This study aimed to find better ways to diagnose tuberculosis (TB) by testing simple, existing tests in new combinations. Researchers worked with over 14,000 people in seven countries, including adults, children, and vulnerable groups, to see if using tests together could spot mo…

This study tested two ways to screen for tuberculosis (TB) in communities in South Africa and Lesotho, where many cases go undiagnosed. It compared using a chest X-ray analysis software alone against combining that software with a simple blood test, before confirming any suspecte…

This study tested a new, easier way to diagnose tuberculosis (TB) using a stool sample instead of hard-to-get sputum. It focused on young children and people living with HIV in Mozambique, Eswatini, and Uganda, where TB is common. The goal was to see if this simpler test could he…

This study aimed to create a faster, simpler way to diagnose tuberculosis (TB) in young children who are severely malnourished and hospitalized. Researchers in Uganda and Zambia tested a combination of easy-to-collect samples and scans to develop a scoring system. The goal was to…

This study tested whether delivering tuberculosis (TB) prevention medicine directly to people's communities helps more people finish their full course of treatment compared to the standard method of requiring monthly clinic visits. It involved 301 adults in South Africa who were …

This study aimed to understand how a tuberculosis drug called pretomanid is processed by the body in people with different levels of kidney impairment. It involved 12 participants, including healthy volunteers and people with mild to severe kidney problems. Researchers gave a sin…

This study aimed to understand how the body processes HIV and tuberculosis medications during pregnancy and after birth. Researchers observed 205 pregnant and breastfeeding women who were already taking these medications for their health care. They measured drug levels in the mot…

This study aimed to create a new research tool, called a 'challenge model,' to help scientists test future tuberculosis (TB) drugs and vaccines more quickly. Twenty healthy volunteers received a small, safe skin injection of the BCG vaccine (a weakened TB-related germ). Researche…

This study tested a new strategy to find people exposed to tuberculosis (TB) in Colombia. Researchers used a mobile app (chatbot) to communicate with patients and their household contacts and collected oral swabs for testing instead of traditional sputum samples. The main goal wa…

This study screened 5,694 people who had just finished a vaccine trial to find hidden tuberculosis cases. Everyone got chest X-rays and sputum tests, even if they felt fine. Researchers collected blood samples to look for biological signs that could help detect TB earlier in the …

This study aimed to understand why some people exposed to tuberculosis bacteria get sick while others don't. Researchers in India examined how malnutrition and worm infections affect the immune system's ability to fight TB. They studied 786 household contacts of TB patients, meas…

This small study aimed to understand how a tuberculosis drug, pretomanid, moves through and concentrates in the bodies of patients. Researchers used a special PET scan to track a tiny, safe amount of a radioactive version of the drug in 10 people with TB. The goal was to see if t…