TUBERCULOSIS

This early-stage trial tested two experimental vaccines (BNT164a1 and BNT164b1) against tuberculosis in 120 healthy adults who had never been exposed to TB or received the BCG vaccine. The main goal was to check safety and find the best dose. Participants received three doses of …

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This study tested an experimental drug called GSK3036656 in combination with other tuberculosis medications in 127 adults with newly diagnosed, drug-sensitive pulmonary TB. Participants received one of several two-drug combinations or standard care for 14 days, then switched to s…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tested a single dose of the drug pretomanid in 32 children with rifampicin-resistant tuberculosis (TB). The goal was to see how the drug moves through the body and whether it is safe when added to their regular TB treatment. The children were monitored for 48 hours aft…

This study tested two different doses of the antibiotic linezolid, combined with three other drugs (bedaquiline, delamanid, and clofazimine), in 138 people with drug-resistant pulmonary tuberculosis. The goal was to see which dose worked better at clearing the infection and was e…

This study tested a once-daily combination of three HIV drugs (tenofovir, emtricitabine, and efavirenz) in 70 adults with both HIV and tuberculosis. Participants had not taken HIV medication before and had been on TB treatment for less than three months. The goal was to see if th…

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study tested whether a stronger tuberculosis (TB) treatment could save more lives in people with HIV and very weak immune systems. Over 1,300 hospitalized patients received either the standard TB drugs or an intensified version with higher doses of two key medicines, plus a …

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This completed trial tested whether zinc and selenium supplements could boost the immune system of tuberculosis patients. Researchers gave 90 adults with pulmonary TB either fortified cookies or a supplement called Myrin P Fort, and measured changes in body measurements, blood co…

This study looked at how safe and tolerable the drug bedaquiline is for children and teens with rifampin-resistant tuberculosis, including those also living with HIV. Fifty-four participants received bedaquiline along with their regular TB treatment for 24 weeks. Researchers meas…

This study tested a new skin test called EC to see if it can accurately diagnose tuberculosis (TB) infection in adults aged 65 and older. Researchers compared EC with a standard TB skin test (TB-PPD) and a blood test (T-SPOT) in 780 participants, including TB patients and healthy…

This study evaluated a new stool-based test (qPCR) to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda tested nearly 2,000 participants to see if the stool test could improve TB detection rates compared to …

This study involved 603 hospitalized children aged 2 to 59 months with severe acute malnutrition in Uganda and Zambia. Researchers tested various diagnostic methods—including chest X-rays, lab cultures, and symptom checks—to develop a score that helps doctors decide whether a chi…

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This completed study tested several tuberculosis (TB) diagnostic tools in over 14,000 people across seven countries. The goal was to find tests that are accurate enough to use in local clinics, without needing special lab equipment. Researchers looked at a simple blood test for C…

This study tested two ways to find tuberculosis (TB) in communities in Lesotho and South Africa. One method used a chest X-ray analyzed by computer software (CAD4TB). The other added a finger-prick blood test (CRP) for people whose X-ray results were unclear. Both methods were fo…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see …

This completed study tested a new public health pack to find and prevent tuberculosis (TB) early in people living with someone who has TB. Over 7,400 participants in Thailand were involved. The pack included active screening, treatment for active TB, and preventive therapy for th…

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HI…

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study examined whether the standard dose of isoniazid, a key tuberculosis drug, is right for all adults. Researchers measured drug levels in 112 patients to see if some were getting too much or too little. The goal was to understand how individual differences in drug process…

This study tested a new drug called MK-7762 in 119 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo in single or multiple doses. The goal was to check for side effects and measure drug levels in the blood, not t…

This study tested whether bringing a portable TB test (Gene Xpert) directly to people in crowded communities helps find and treat more TB cases than the usual method of waiting for people to visit a clinic. Over 3,500 adults in South Africa took part. The goal was to see if this …

This study tested a simple way to get more HIV patients in South Africa the medicine that prevents tuberculosis (TB). Instead of doctors having to choose to prescribe it, the new approach made TB prevention the standard option, requiring doctors to actively opt out if they didn't…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This completed study looked for tuberculosis (TB) cases in 5,694 people who had already finished a COVID-19 vaccine trial. Participants had physical exams, blood tests, and tongue swabs to find TB and study related biomarkers. The goal was to understand how common TB is in this g…

This study looked at why some people infected with TB bacteria get sick while others don't. Researchers in India studied 120 household contacts of TB patients, comparing those who were malnourished or had parasitic worms. They provided food and deworming medication to see how the…

This study tested a new method to evaluate tuberculosis (TB) drugs and vaccines in 20 healthy adults. Researchers used a harmless version of the TB bacteria (BCG) to see how the body fights it and how treatments work. The goal was to create a faster, safer way to test new TB trea…

This study used a special PET scan to track how the tuberculosis drug pretomanid moves through the body. Ten people with or without TB received a tiny radioactive version of the drug, and the scanner measured where it went. The goal was to see how much drug reaches infected areas…

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and their newborns. Researchers measured drug levels in blood and vaginal fluids to see if dosing needs to change during pregnancy and after birth. Over 1,500 women took p…

This study looked at how the tuberculosis drug pretomanid is processed in people with different levels of kidney function. Twelve participants received a single 200 mg dose, and researchers compared drug levels in those with kidney impairment to healthy matched controls. The goal…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and new mothers. Researchers measured drug levels in the blood of 205 women during pregnancy and after delivery to see if standard doses are effective. The goal was to gat…

This study tested a new way to find people exposed to tuberculosis (TB) in Cali, Colombia. Instead of relying only on in-person visits, researchers used a mobile phone chatbot and a simple oral (mouth) test that people could do at home. The goal was to see if this approach was pr…

This completed Phase 3 study measured how high doses of the tuberculosis drugs rifapentine and moxifloxacin move through the body in 53 adults with TB. Participants gave multiple blood samples to track drug levels. The goal was to understand the best doses to kill TB bacteria whi…

This study tested a new AI system (Janus Pro 1B-CXR) designed to help radiologists interpret chest X-rays. The AI was developed using public data and evaluated in 296 patients with suspected chest diseases. Researchers compared report quality, reading time, and agreement between …