TUBERCULOSIS

This early-stage trial tested two experimental vaccines against tuberculosis in 120 healthy adults who had never received a TB vaccine or been exposed to TB. The main goal was to check safety and find the best dose. Participants received three shots of either a vaccine or a place…

This study looked at whether adding metformin, a diabetes medicine, to standard antibiotics for tuberculosis (TB) is safe and tolerable for people also living with HIV. 112 adults with both HIV and TB took either standard TB drugs alone or with metformin for 11 weeks. Researchers…

This study tested a once-daily combination of three HIV drugs (tenofovir, emtricitabine, and efavirenz) in 70 adults with both HIV and tuberculosis who had not taken HIV medication before. The goal was to see if a simpler, once-daily pill routine could effectively control HIV whi…

This study looked at how safe and effective the drug bedaquiline is for children and teens with a hard-to-treat form of tuberculosis (TB) that is resistant to the antibiotic rifampin. The trial included 54 participants, some of whom also had HIV. Researchers monitored side effect…

This study looked at whether giving HIV-infected infants (aged 1 month to 1 year) early treatment for two common infections—cytomegalovirus (CMV) and tuberculosis (TB)—could help them survive severe pneumonia. Over 560 babies participated across multiple hospitals. The goal was t…

This study tested two different doses of the drug linezolid, combined with three other medicines, to treat drug-resistant tuberculosis (TB). The goal was to see if a lower dose could work just as well but with fewer side effects. 138 adults with drug-resistant TB took part. The r…

This study tested new combinations of TB drugs to see how quickly they kill TB bacteria in the lungs. 127 adults with drug-sensitive TB took one of several experimental two-drug combos or standard care for 14 days. After that, everyone switched to standard TB treatment. The goal …

This study tested whether a stronger tuberculosis (TB) treatment could reduce deaths in people with HIV who have very low CD4 counts (≤100). Over 1,300 hospitalized adults and teens received either an intensified regimen (higher doses of some TB drugs plus steroids) or the standa…

This study looked at whether adding zinc and selenium to cookies could help tuberculosis patients fight the infection. Researchers gave 90 adults with TB either regular or fortified cookies and measured changes in their body measurements and blood. Results suggest these minerals …

This study worked to create a simple score to help doctors diagnose tuberculosis (TB) in hospitalized children aged 2 months to 5 years who are severely malnourished. Researchers in Uganda and Zambia tested different diagnostic methods on 603 children to find the most accurate co…

This study tested two methods for finding tuberculosis (TB) in communities in Lesotho and South Africa. About 20,000 adults were screened using either chest X-ray alone or chest X-ray plus a quick blood test (CRP). The goal was to see if adding the blood test finds just as many T…

This study tested a new stool-based test to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda enrolled nearly 2,000 participants to see if the test could find more TB cases than current methods. The goal is …

This study tested different ways to diagnose tuberculosis (TB) in over 14,000 people across seven countries. The goal was to find which tests work best in local clinics and for vulnerable groups like people with HIV and refugees. By identifying more accurate and practical tests, …

This study tested whether giving TB prevention medicine in the community with fewer refill visits helps more people finish their treatment compared to the usual monthly clinic visits. 301 adults in South Africa who were at risk for TB took part. The goal was to see if the communi…

This study tested a simple change in how clinics prescribe TB prevention medicine to people with HIV. Instead of doctors having to choose to prescribe it, the new approach made TB prevention the automatic option unless the doctor decided to opt out. Over 50,000 adults in South Af…

This study tested a new approach to find and prevent tuberculosis (TB) early in people who live with someone diagnosed with TB. Over 7,400 participants in Thailand were involved. The goal was to see if starting preventive treatment faster could reduce illness and spread of the di…

This study looked at how the tuberculosis drug pretomanid is handled by the body in people with different levels of kidney function. Researchers gave a single dose to 12 adults with normal or impaired kidneys and measured drug levels and safety. The goal was to see if kidney prob…

This study aimed to create a human challenge model for tuberculosis (TB) using a harmless bacteria called BCG. Twenty healthy adults received BCG under the skin to see how the body fights it and how TB drugs might work. The goal is to test new TB vaccines and treatments faster an…

This study tested a new way to find people exposed to tuberculosis (TB) in Cali, Colombia, using a smartphone chatbot and a simple mouth-swab test at home. Researchers worked with 269 participants to see if this approach was practical and easy to use. The goal was to prepare for …

This study looked at how two tuberculosis drugs, rifapentine and moxifloxacin, are processed in the body. Researchers took blood samples from 53 adults with TB to measure drug levels and see how they relate to treatment success and side effects. The goal is to improve dosing for …

This study checked nearly 5,700 adults who had been in a COVID-19 vaccine trial to see how many had tuberculosis (TB). Researchers measured TB rates and looked for links to age, gender, and other factors. They also tested blood samples for markers that might help spot TB earlier.…

This study looked at how to best prevent tuberculosis (TB) in Malaysian prisoners, especially those with opioid addiction and HIV. Researchers compared a standard 9-month daily TB prevention medicine to a shorter 3-month weekly option. The goal was to see which approach works bet…

This study used special PET scans to track where the tuberculosis drug pretomanid goes in the body. Ten people with TB received a tiny radioactive version of the drug, and scans showed how much reached infected areas like lung cavities. The goal was to learn how the drug behaves,…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with respiratory conditions like COPD, asthma, and COVID-19. Researchers compared the app's cough counts to patients' own reports and to human listeners. The goal was t…

This completed study looked at how HIV and tuberculosis medications behave in the bodies of pregnant women and new mothers. Researchers measured drug levels in 205 women during pregnancy and after delivery to find the right doses. The goal was to make sure both mother and baby ge…

This study looked at why some people infected with TB bacteria get sick while others don't. Researchers in India studied 120 household contacts of TB patients, comparing those who were malnourished or had parasitic worms. They provided food and deworming medication to see how the…

This study tested whether adding a rapid TB test (Xpert Ultra) to standard care helps find tuberculosis earlier in young children hospitalized with severe pneumonia. Over 2,500 children aged 2 to 59 months from six high-TB-burden countries took part. The goal was to see if early …