Could a simple TB test save kids with pneumonia?

NCT ID NCT03831906

Completed Diagnosis Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on nose and stool samples at admission to find TB early and start treatment right away.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Xpert MTB/RIF Ultra diagnostic test
What this could lead to: If successful, this approach could help identify tuberculosis earlier in children with pneumonia, potentially reducing deaths by starting treatment sooner.
What could go wrong: This is a completed diagnostic trial, not a treatment study. The test may not significantly lower mortality, and results may vary across different settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 pneumonia tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID19 SEVERE PNEUMONIA TUBERCULOSIS

Contacts and locations

Locations

Angré University Teaching Hospital

Abidjan, Côte d’Ivoire
Arthur Davidson Children Hospital

Ndola, Zambia
Biyem Assi District Hospital

Yaoundé, Cameroon
Chantal Biya Foundation

Yaoundé, Cameroon
Cocody University Teaching Hospital

Abidjan, Côte d’Ivoire
Holy Innocents Children's Hospital

Mbarara, Uganda
Jinja Regional Reference Hospital

Jinja, Uganda
José Macamo General Hospital

Maputo, Mozambique
Kampong Cham Provincial Referral Hospital

Kampong Cham, Cambodia
Lusaka University Teaching Hospital

Lusaka, Zambia
Maputo Central Hospital

Maputo, Mozambique
Mulago National Referral Hospital

Kampala, Uganda
National Pediatric Hospital

Phnom Penh, Cambodia
Takeo Provincial Referral Hospital

Takeo, Cambodia
Treichville University Teaching Hospital

Abidjan, Côte d’Ivoire
Yopougon University Teaching Hospital

Abidjan, Côte d’Ivoire

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