TUBERCULOSIS

This study tests two experimental vaccines designed to prevent tuberculosis (TB) in adults who have already received the BCG vaccine and are HIV-negative. About 500 healthy volunteers aged 18 to 55 (or older) will receive different doses to find the safest and most effective dose…

This large-scale study is testing whether an experimental vaccine called M72/AS01E-4 can prevent tuberculosis (TB) in adolescents and adults. About 20,000 volunteers are receiving either the vaccine or a placebo to see if it safely stops TB infection. The goal is to find a new wa…

This study tests whether a food supplement called Nyaditum resae® can reduce the gut problems caused by standard tuberculosis (TB) antibiotics. About 48 adults with new, drug-sensitive TB will take either the supplement or a placebo alongside their regular TB treatment. The goal …

This study looks at how a single dose of the medicine pretomanid works in children with rifampicin-resistant tuberculosis (a hard-to-treat form of TB). The goal is to understand how the drug moves through the body and whether it is safe and acceptable for children. About 32 child…

This study tests a combination of digital tools, family support, and healthcare worker training to find more tuberculosis (TB) cases and help patients complete their treatment. About 278 people with TB, their families, and health workers in South Ethiopia will take part. The goal…

This study tests whether a 1-month daily TB prevention pill works as well as a 3-month weekly option in two groups: people living with HIV and HIV-negative household contacts of TB patients. About 1,000 participants in South Africa and India will be randomly assigned to one of th…

This study looks at how tuberculosis (TB) medicines behave in the bodies of breastfeeding mothers and their infants. Researchers will measure drug levels in the mother's blood and breastmilk, as well as in the baby's blood, after the mother takes her TB pills. The goal is to unde…

This study aimed to see if the BCG vaccine could protect healthy adults from tuberculosis (TB) by measuring how the body fights the bacteria. It planned to enroll 64 people aged 18-45, giving some the vaccine and later a controlled exposure. However, the study was withdrawn befor…

This study looks at how safe and effective a short, once-weekly treatment for latent tuberculosis (TB) is in children and teens with HIV who are taking the antiretroviral drug dolutegravir. The goal is to see if the TB drugs interact with the HIV medication and to check for side …

This study tests whether giving the BCG vaccine as an inhaled mist works better than the usual injection for boosting immunity against tuberculosis. It includes 36 healthy adults who have already had the BCG vaccine, some with type 2 diabetes and some without. Researchers will me…

This study tests whether computer-assisted X-rays and other simple tests can help find more cases of tuberculosis (TB) and COVID-19 in African communities. About 26,200 adults will be screened using these tools to see if they can detect cases that are usually missed. The goal is …

This study compares two tests for latent tuberculosis (a hidden TB infection) in 200 people with HIV in Liberia. Participants receive a skin test and a blood test to see which one works better. The goal is to find the best way to screen for TB in this high-risk group.

This study tests the safety of a new tuberculosis (TB) vaccine called ID93/GLA-SE. Forty-eight healthy adults, some previously vaccinated with BCG and some not, will receive the new vaccine and then be exposed to a harmless form of TB bacteria through an aerosol mist. Researchers…