TUBERCULOSIS

This study tests whether adding steroids and stronger antibiotics to standard care improves survival for HIV patients with severe sepsis in Africa. Researchers will compare different treatment combinations in 344 hospitalized adults to see which approach works best. The goal is t…

This study is testing a shorter, all-pill treatment for a difficult form of tuberculosis (TB) that resists standard antibiotics. It will enroll 120 Chinese participants aged 12 and older to see if a 9-month course of four specific oral drugs is effective and safe. The goal is to …

This study is testing a new automated machine called PATHFAST to see if it can quickly and accurately tell whether tuberculosis (TB) treatment is working. Researchers will follow 300 adult TB patients in Nairobi, Kenya, collecting sputum and urine samples regularly during their 6…

This study aims to see if using new, easier diagnostic tests for tuberculosis (TB) can help healthcare clinics find and report more TB cases. Researchers will compare clinics using a package of new tests and community outreach against clinics using standard methods. The goal is t…

This study is testing a new, non-invasive blood and urine test to diagnose tuberculosis (TB) and monitor treatment. It aims to provide a faster, easier alternative to current methods like sputum samples or invasive biopsies, which can be difficult for some patients. Researchers w…

This study aims to find out if a newer biopsy method using a freezing probe is better at diagnosing tuberculosis in chest lymph nodes than the standard needle method. Researchers will test both methods on the same lymph node in 108 adults suspected of having TB. The goal is to se…

This study aims to find the safest and most effective dose of a 28-day medicine combination to prevent tuberculosis (TB) in children under 13 years old. It will include up to 144 children, both with and without HIV, who are at risk of getting TB. Researchers will closely monitor …

This study is testing if bringing tuberculosis (TB) prevention services to families' homes works better than asking them to go to a clinic. It will involve 1,300 children in Ethiopia who live with someone who has TB. The goal is to see if home visits by trained health workers hel…

This study aims to create a tool to help doctors better predict which hospitalized patients have tuberculosis. Researchers will collect information from about 686 adult patients who are suspected of having TB. The goal is to develop a score that helps decide who needs isolation f…

This research study aims to understand how the body's immune cells behave differently in people with various lung diseases like asthma, COPD, and pneumonia. Researchers will analyze a single blood sample from 100 participants to look for patterns in how certain white blood cells …