HIV drug resistance showdown: stay or switch?

NCT ID NCT06747507

Recruiting now Disease control Sponsor: University of Nairobi Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This trial looks at what to do when the HIV virus becomes resistant to the drug dolutegravir. It compares staying on dolutegravir versus switching to another drug combination (darunavir/ritonavir) to see which better lowers the virus level. About 392 people with HIV and specific resistance mutations will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dolutegravir pill or darunavir+ritonavir pill
What this could lead to: If it works, this could show the best way to manage HIV when the virus becomes resistant to dolutegravir, helping more people achieve viral suppression.
What could go wrong: This is a Phase 3 trial, but it only includes people with specific resistance mutations, so results may not apply to everyone. There is also a risk that neither strategy works well.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION

Contacts and locations

Locations

Bomu Hospital
NOT_YET_RECRUITING

Mombasa, Kenya
Butha-Buthe District Hospital
NOT_YET_RECRUITING

Butha-Buthe, Lesotho
CS Machava II
NOT_YET_RECRUITING

Maputo, Mozambique
CS Ndlavela
NOT_YET_RECRUITING

Maputo, Mozambique
CS Ponta Gea
NOT_YET_RECRUITING

Beira, Sofala, Mozambique
Jaramogi Oginga Odinga Teaching and Referral Hospital
RECRUITING

Kisumu, Kenya
Kenyatta National Hospital
RECRUITING

Nairobi, 00100, Kenya
MUHAS Clinical Trial Unit
NOT_YET_RECRUITING

Dar es Salaam, Tanzania
Mokhotlong District Hospital
NOT_YET_RECRUITING

Mokhotlong, Lesotho

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