METHAMPHETAMINE USE DISORDER

This early-stage study will test whether psilocybin, the active ingredient in magic mushrooms, is safe and can help people stop using methamphetamine. About 20 adults who want to quit meth will receive psilocybin in a controlled setting. Researchers will measure how many people s…

This study tests a new type of brain stimulation (rTMS) that targets two brain areas to help people with methamphetamine addiction. The goal is to improve cognitive flexibility and reduce cravings. 70 adults with severe methamphetamine use disorder will receive the treatment and …

This study tests a program that gives rewards (like gift cards) to people in Hawaii who stop or reduce methamphetamine use after a serious injury. About 40 adults who tested positive for meth in the hospital will join. They will provide urine samples up to three times a week for …

This study tests whether an accelerated form of brain stimulation (TMS) can help people with moderate to severe methamphetamine use disorder reduce their drug use and cravings. Twenty participants will receive either real or sham TMS to see if the treatment is safe, tolerable, an…

This study tests whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks helps people with moderate to severe methamphetamine use disorder stay in treatment and reduce use. About 80 adults who completed a prior trial will receive either the drug or a pla…

This study tests whether a medication called troiluzole can reduce the appeal of methamphetamine. Forty adults who use meth but are not seeking treatment will take the drug and then choose between meth and money in a lab setting. The goal is to see if troiluzole makes people less…

This small study tests whether combining a non-invasive brain stimulation technique (rTMS) with a mental exercise called Episodic Future Thinking (imagining positive future events) can help people with methamphetamine use disorder make less impulsive choices and reduce their desi…

This study tests whether deep transcranial magnetic stimulation (dTMS) can help Veterans with methamphetamine use disorder reduce their drug use. About 30 participants will receive brain stimulation targeting addiction-related circuits. The goal is to see if this treatment can lo…

This early-stage study tests whether pentoxifylline, an anti-inflammatory drug, can reduce the rewarding effects of cocaine in 30 adults with cocaine use disorder. Participants will choose between cocaine and money to see if the drug lowers cocaine's appeal. The goal is to find a…

This study looks at whether reducing methamphetamine use, even without quitting completely, leads to real health and life improvements. Researchers will track 300 adults seeking treatment for methamphetamine use disorder over 12 weeks and then for another 12 weeks after. The goal…

This study looks at heart electrical patterns (ECGs) in 240 people with methamphetamine use disorder, some of whom also have psychosis. Researchers compare ECGs at the start of treatment and before discharge to see if psychosis adds extra heart risk. The goal is to better underst…

This study examines levels of two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with meth-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves …