METHAMPHETAMINE USE DISORDER

This study tests a new type of brain stimulation that sends paired pulses to the cerebellum and prefrontal cortex. The goal is to reduce cravings and improve cognitive flexibility in 90 adults with moderate to severe methamphetamine use disorder. Participants will receive either …

This study tests whether a drug called troiluzole can reduce the appeal of methamphetamine for people with methamphetamine use disorder. About 40 adults who use meth but are not seeking treatment will take the drug and then choose between meth and money in a lab setting. The goal…

This study tests whether pentoxifylline, an anti-inflammatory drug, can reduce how rewarding cocaine feels. Thirty adults with cocaine use disorder who are not seeking treatment will take the drug and then choose between cocaine and money. The goal is to see if calming immune inf…

This study tests whether reducing methamphetamine use—without requiring complete abstinence—can improve health and quality of life. Researchers will give 300 adults with methamphetamine use disorder payments for providing drug-free urine samples over 12 weeks. They will measure b…

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This study tests a program that gives rewards (like gift cards) to people in Hawaii who are trying to stop using methamphetamine after a serious injury. 40 adults who were hospitalized and tested positive for meth will visit a clinic up to three times a week for urine tests. Rese…

This study looks at whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks is feasible and acceptable for people with moderate to severe methamphetamine use disorder. About 80 participants will receive either the drug or a placebo alongside their usual …

This early-stage study will test whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for people trying to quit methamphetamine. Twenty adults in northern Louisiana who want to stop using meth will receive psilocybin in a controlled setting. Researc…

This study tests whether an accelerated form of Transcranial Magnetic Stimulation (TMS) can help people with moderate to severe methamphetamine use disorder. Twenty participants will receive either real or sham TMS to the brain's prefrontal cortex. Researchers will check if the t…

This study tests whether deep transcranial magnetic stimulation (dTMS) can help veterans with methamphetamine use disorder. Researchers will stimulate a brain region called the insula, which is involved in cravings and decision-making. Thirty veterans will receive either real or …

This early study tests whether combining a non-invasive brain stimulation technique (rTMS) with a mental exercise called Episodic Future Thinking (imagining positive future events) can help people with methamphetamine use disorder make less impulsive choices and reduce their desi…

This study looks at heart electrical patterns (ECGs) in 240 people hospitalized for methamphetamine use, comparing those with and without psychosis. Researchers will check ECGs at admission and before discharge to see if psychosis is linked to more heart strain. The goal is to be…

This study measures two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves…