Could a pill curb Cocaine's high? early trial tests safety
NCT ID NCT06273540
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-stage trial tested whether a drug called STP7 (mavoglurant) can safely reduce the physical and psychological effects of cocaine in 21 adults who use cocaine but are not seeking treatment. Participants received either STP7 or a placebo, then were given intravenous cocaine to monitor heart rate, blood pressure, and subjective effects. The goal was to check for dangerous interactions and see if STP7 might one day help treat cocaine use disorder.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
STP7 (mavoglurant)
What this could lead to
If it works, this could point toward a treatment that helps people with cocaine use disorder by reducing the drug's rewarding effects.
What could go wrong
This is a very early Phase 1 safety study with only 21 participants, so it cannot prove effectiveness. The drug may not reduce cocaine's effects or could have side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Altasciences Clinical Kansas
Overland Park, Kansas, 66212, United States