Could a pill replace the shot? new study tests oral buprenorphine for opioid treatment
NCT ID NCT06086275
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 study tested how the body processes different doses of oral buprenorphine compared to an intravenous dose. Eighteen healthy adults with past opioid use received three different doses in separate visits. Researchers measured drug levels in the blood over 24 hours to understand how oral buprenorphine might be used as a low-dose induction strategy for opioid use disorder.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
buprenorphine
What this could lead to
If successful, this could help develop safer ways to start buprenorphine treatment for opioid use disorder, reducing withdrawal symptoms.
What could go wrong
This is a very early Phase 1 study with only 18 healthy volunteers, not people with opioid use disorder. Results may not apply to real-world patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's hospital
Boston, Massachusetts, 02115, United States