OPIOID USE DISORDER

This study tests whether adding peer-based counseling to standard HIV and opioid treatment helps people who inject drugs stay on their medications and achieve viral suppression. Participants receive either enhanced usual care or extra support from a peer counselor. The goal is to…

This study looked at whether different medications for opioid use disorder (methadone, buprenorphine/naloxone, or naltrexone) could reduce immune system inflammation in people with HIV. Researchers measured changes in blood markers of immune activation over 24 weeks. The trial wa…

This study tested a mobile app that uses rewards to encourage people with opioid use disorder to start and stick with medication-assisted treatment after an emergency room visit. 41 adults from two hospitals were given access to the app for 12 weeks. The goal was to see if the ap…

This early study tested a new drug called TRV734 in 5 adults with opioid-use disorder who were already on methadone. The goal was to see if TRV734 could relieve withdrawal symptoms with fewer side effects than a standard opioid like oxycodone. Participants stayed in a residential…

This study looked at whether buprenorphine can effectively treat chronic pain in people who are dependent on opioid painkillers, while also reducing withdrawal symptoms and improving quality of life. It involved 4 adults with opioid dependence and chronic pain. The approach was t…

This study tested a new method for starting buprenorphine (a medication for opioid use disorder) in hospitalized adults who also have chronic pain. Instead of requiring patients to stop all other opioids and go through withdrawal first, the new method starts with very low doses o…

This study tested a device called Bridge to see if it could reduce symptoms of opioid withdrawal. Researchers compared it to a fake device in 13 adults with opioid use disorder. The study was stopped early, so results are limited.

This study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs se…

This study aimed to understand how withdrawal symptoms and drug-related cues influence decision-making in people with opioid use disorder. Participants completed choice tasks to see if they preferred high-probability rewards. The study was terminated early and only enrolled 2 par…