OPIOID USE DISORDER

This early-stage study is testing whether psilocybin, the active compound in 'magic mushrooms,' is safe for people with opioid addiction who are taking buprenorphine medication. Researchers will give 10 participants two doses of psilocybin while they continue their regular addict…

This study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help people with opioid addiction who are still using illicit drugs despite being on standard methadone treatment. It will involve 240 participants who will receive either a l…

This study is testing a comprehensive 24-week program for people who have both opioid addiction and long-term pain. The program combines standard addiction medication with therapy, exercise groups, and stress-reduction techniques like tai chi and relaxation training. Researchers …

This study is testing whether a private Facebook support group can help Native American women in Minnesota stay off opioids and continue their recovery medication. Researchers will enroll 60 women who are already in recovery and using medication for opioid use disorder. The goal …

This study is testing if a smartphone app can help people who use both opioids and cocaine stay in methadone treatment longer and use drugs less often. Participants are randomly assigned to receive either standard methadone treatment or the same treatment plus the app. The app as…

This study is testing whether a handheld device that gently stimulates a nerve in the neck can help people with opioid addiction. Participants stay in a hospital for about a week to see if the device safely reduces withdrawal symptoms and cravings. The goal is to see if this non-…

This study is testing whether adding a non-invasive brain stimulation technique (tDCS) and cognitive training exercises helps people who are already taking buprenorphine medication for opioid addiction. Researchers want to see if this combination can improve brain function relate…

This study is testing if pills containing THC and CBD, the main compounds in cannabis, can help people who have both chronic pain and an addiction to opioid drugs. The 147 participants are already receiving standard methadone treatment. Researchers want to see if different doses …

This study aims to see if providing free e-cigarettes is more effective than counseling and nicotine patches at helping people who smoke and have opioid use disorder reduce their cigarette smoking. It will enroll 302 adults who are in treatment programs for opioid use and smoke a…

This study is testing if a smartphone app that gives cash rewards can help people with opioid, cocaine, or methamphetamine addiction stay drug-free. The app tracks participants' progress with at-home drug tests and rewards them with money for clean results. Researchers want to se…

This study is testing a smartphone app designed to help people who are in treatment for both opioid and alcohol addiction. It aims to see if the app is easy to use and helpful for 50 adults on Michigan Medicaid. The app uses a reward system to encourage people to stay on track wi…

This study is testing a new support program called THRIVE for people leaving the hospital who have opioid use disorder. It aims to see if connecting patients with a trained peer specialist for in-person and text message support can help reduce dangerous overdoses and skin infecti…

This pilot study is preparing for a larger trial to see if connecting people to local recovery community centers helps those using medication for opioid addiction. Researchers will compare two groups: one that visits recovery centers and another that chooses other recovery activi…

This study compares two forms of the addiction medication buprenorphine: a daily pill placed under the tongue versus a monthly injection. Researchers want to see which form helps people who use fentanyl or similar strong opioids stay drug-free longer and avoid relapse. The trial …

This study is testing whether a smartphone app with an animated virtual coach can help people stay on their medication for opioid addiction. One hundred people starting treatment at Boston Medical Center will be randomly assigned to either use the app with reminders and support o…

This study is testing a new therapy called HOPE for people who have both opioid addiction and post-traumatic stress disorder (PTSD). Participants must already be taking medication for their opioid addiction. The research will compare whether adding this 10-12 week therapy to stan…

This study is testing whether low doses of ketamine can help reduce cravings and withdrawal symptoms in adults who are starting methadone treatment for opioid addiction. Researchers will compare two different low doses given four times over two weeks to see which works better. Pa…

This early-stage study is testing whether a non-invasive, focused ultrasound device can safely target and influence specific brain areas involved in addiction. The goal is to see if this technology could become a new tool to help people with opioid or other substance use disorder…

This study aims to implement and test culturally tailored screening and brief support for chronic pain and opioid misuse in three clinics serving American Indian and Alaska Native communities. Researchers will work with community partners to develop training for healthcare provid…

This study aims to find out if follow-up care via video or phone (telehealth) works better than traditional in-person clinic visits for people starting medication for opioid addiction in the emergency room. Researchers will track over 500 patients to see which method helps people…

This study is testing whether directly treating feelings of loneliness can help people who are struggling with opioid addiction. It will enroll 300 adults who have both an opioid use disorder and report feeling lonely or disconnected. Participants will be randomly assigned to one…

This study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help people with opioid addiction. Researchers will give 36 people in treatment either a 25mg dose or a very low 1mg dose to see if the higher dose improves their ability to t…

This study is testing whether having a peer support worker—someone who has personally recovered from addiction—in the emergency room helps people with substance use disorders get connected to treatment and social services. Researchers will follow 400 people for 6 months to see if…

This study is testing whether adding tirzepatide, a medication currently used for diabetes and weight loss, to standard buprenorphine treatment helps people with opioid addiction. Researchers will enroll 310 adults who recently started buprenorphine treatment and randomly assign …

This study is testing if a higher daily dose (24 mg) of the addiction medication buprenorphine helps people with fentanyl addiction stay in treatment longer than the standard dose (16 mg). Researchers will enroll 250 adults in Rhode Island who are starting or continuing treatment…

This study aims to expand access to medication-assisted treatment for opioid addiction in Kazakhstan, Kyrgyzstan, and Tajikistan. Researchers will work with local healthcare providers to implement and improve treatment programs, with the goal of helping more people get treatment …

This study is testing a new support program designed to help young adults (ages 18-28) with opioid addiction stick with their medication treatment. The program includes home delivery of medication, family support, and regular check-ins via text and social media. Researchers want …

This study is testing a decision-making tool designed to help emergency room patients with opioid addiction understand and choose buprenorphine treatment. The tool will be compared to standard care to see if it improves patient knowledge, reduces decision-making stress, and incre…

This study is testing if semaglutide, a medication currently used for diabetes and weight loss, can help people with opioid addiction. It will involve 46 adults who are already taking buprenorphine treatment. Participants will receive weekly injections of either semaglutide or a …

This study is testing whether MDMA-assisted therapy can help new mothers who are struggling with both post-traumatic stress disorder (PTSD) and opioid addiction. It will involve 15 participants who are 6 to 12 months postpartum and are already receiving stable treatment for their…

This study aims to see if a special brain scan (MRI) can predict which people with opioid addiction will succeed in quitting while taking the medication buprenorphine. It also tests whether a non-invasive magnetic brain stimulation treatment (rTMS) helps people stay off opioids b…

This study is testing whether a 10-session phone or online coaching program can help people who have both chronic pain and problems with opioid use. Researchers want to see if this program helps participants manage their pain better and stay engaged in treatment for opioid use di…

This study is testing whether a non-invasive, focused ultrasound treatment can help people with severe opioid addiction who haven't been helped by other treatments. It's a small, early-stage trial to check if the procedure is safe and if it might reduce drug use. Some participant…

This study is testing whether a therapy program with a supporting mobile app can help pregnant people stay on their prescribed medication for opioid use disorder. It compares this app-based support to simply tracking medication use in a diary. The goal is to see which approach is…

This study is testing if a buprenorphine skin patch can help pregnant women with opioid addiction start treatment with less severe withdrawal symptoms. Normally, patients must go through withdrawal before beginning medication, but the patch may ease this difficult period. Researc…

This study is testing a patient navigation program called NavSTAR across several Philadelphia hospitals. The program provides support to help adults with opioid use disorder start medication treatment and navigate care after they leave the hospital. Researchers want to see if thi…

This study is testing whether a non-invasive brain stimulation device can help people with opioid addiction and chronic pain. The device uses a combination of mild electrical and ultrasound stimulation. Researchers will measure if it helps participants reduce their drug use and m…

This study is testing whether a telehealth platform can make treatment for opioid addiction more accessible and effective for people who need it. It will enroll 250 people with opioid use disorder who are starting medication treatment. Researchers will see if participants find th…

This study is testing a support program designed to help teenagers with opioid addiction stay on their prescribed medication. The program involves family members, easy access to treatment, and positive rewards for sticking with the plan. Researchers want to see if this approach h…

This study is testing a new system designed to help people with opioid addiction continue their treatment after they are released from jail. It focuses on improving the handoff between jail-based care and community clinics to prevent relapse. The goal is to see if this coordinate…

This study is testing different ways to help adults with opioid addiction who come to the emergency room. It aims to find the best combination of support to help them stay on a medication called buprenorphine for longer. The goal is to reduce the risk of overdose and improve long…

This study is testing whether a specially adapted form of talk therapy, delivered by video call, can help treat PTSD in adults who are receiving medication for opioid addiction at syringe service programs. The main goal is to see if offering this therapy onsite is practical and a…

This study aims to find out if a monthly injection for opioid addiction works better than the standard daily pills at helping veterans stay in treatment and avoid using opioids. It will follow 952 veterans with opioid addiction for one year to see which treatment leads to better …

This study aims to find out which of two forms of the addiction medication buprenorphine works better for people with opioid addiction who are leaving jail. It will enroll 240 adults from a large city jail and randomly assign them to receive either a monthly injection or daily ta…

This study is testing a new, low-dose method to help people with opioid addiction start a medication called buprenorphine. Researchers want to see if giving it as a single, long-acting injection is safe and prevents severe withdrawal symptoms. They are enrolling 30 adults who are…

This study is testing if starting medication for opioid addiction with very small, gradually increasing doses is safe and helps people stick with treatment. It will compare this gentle start to the usual way of beginning treatment in 70 adults with opioid use disorder. Researcher…

This study is testing whether adding support from a trained peer who has personal experience with addiction and recovery helps people stay in their medication treatment for opioid use disorder. Researchers will compare two groups: one receiving standard clinic care plus meetings …

This study is testing if a special outpatient clinic that treats both addiction and infections together is better than usual care at keeping people out of the hospital. It will involve about 304 adults who are hospitalized with serious infections from injecting drugs. The goal is…

This small pilot study is testing whether deep brain stimulation can help people with severe opioid addiction who haven't responded to other treatments. Three participants will receive brain implants that deliver electrical pulses to a specific brain area involved in addiction. R…

This study is testing if starting a monthly injection for opioid addiction right when someone enters jail is better than keeping them on daily pills. It involves 200 people with opioid use disorder who are awaiting trial. The goal is to see which approach helps people stay on the…

This study is testing if starting people on a higher dose of the addiction medication buprenorphine in the emergency room is safe and helps more people get into follow-up treatment. It focuses on people with opioid addiction who test positive for fentanyl. The goal is to see if a…

This study is testing if a smartphone app can help doctors better treat opioid addiction. The app predicts a patient's risk of using opioids again soon. Doctors can then use this information to adjust the patient's medication dose, aiming to reduce the chance of relapse compared …

This study is testing whether daily morning bright light therapy can help people recovering from opioid addiction. Researchers want to see if this simple, non-drug treatment improves sleep patterns and reduces drug cravings. About 105 participants receiving standard medication tr…

This study is testing whether a new injectable medicine called brenipatide, when added to standard buprenorphine treatment, can help people with opioid addiction stay off drugs. About 465 participants will receive either the new medicine or a placebo injection alongside their usu…

This study is testing a short counseling program designed specifically for people receiving medication treatment for opioid addiction who also drink alcohol. The program aims to help reduce alcohol use, which can increase the risk of overdose and make opioid treatment less effect…

This study tests a community program that helps young people with opioid addiction get treatment faster. The program sends outreach teams to connect youth with medication, counseling, and peer support right away. Researchers want to see if this approach helps young people stay in…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' can change brain activity related to drug cravings and self-control in people with opioid addiction. Researchers will give 24 participants either a low or high dose and use brain scans to see how …

This study compares two common medications for opioid addiction—methadone and buprenorphine—to see which one helps people stay in treatment longer when prescribed in a regular doctor's office. About 600 adults starting new treatment for opioid addiction will be randomly assigned …

This study is testing a bundled support program designed to help people with opioid addiction continue their treatment after leaving the emergency room. The program combines telehealth check-ins, peer support specialists, medication (buprenorphine), and help connecting to ongoing…

This study tests whether a computer alert system can help doctors prevent opioid overdoses. A machine-learning model identifies patients at high risk, and then the system sends reminders to doctors about safer prescribing practices. The goal is to see if these alerts lead to fewe…

This study aims to prevent opioid and other substance use disorders in homeless youth, a group at very high risk. Researchers are testing different combinations of counseling and practical support services to see which work best. They will follow 300 young people aged 14-24 for t…

This study is testing if the compound CBD (cannabidiol) can safely help people who have both opioid addiction and long-term pain. Researchers will give different doses of CBD to 34 people who are already receiving standard medication treatment for their addiction. They will measu…

This study is testing a smartphone app designed to help people who are starting medication treatment for opioid addiction get better sleep. The app uses proven techniques from sleep therapy. Researchers will enroll 40 people to see if the app is easy to use and if it helps improv…

This study is testing a new group therapy delivered over Zoom to help adults who have both chronic pain and opioid use disorder. The therapy focuses on understanding and expressing emotions to reduce pain, disability, and opioid-related problems. Researchers want to see if this a…

This early-stage study is testing whether cannabis can help reduce withdrawal symptoms in people with opioid use disorder who are not currently in treatment. Researchers will measure how participants feel, their craving for opioids, and their breathing safety. The goal is to see …

This small pilot study is testing a smartphone app called 'Mindful Journey' to see if it's helpful and easy to use for adults who are in recovery from opioid addiction and also have chronic pain. The app delivers short, on-the-spot mindfulness videos and exercises to help people …

This early-stage study is testing whether adding an existing epilepsy drug, lacosamide, to standard opioid painkillers is safe and tolerable for adults with chronic pancreatitis. The main goal is to see if the combination helps reduce severe abdominal pain and might allow patient…

This study is testing a gentle, non-invasive ultrasound technique on the brain to see if it can help people who struggle with chronic back pain, opioid addiction, and anxiety. Researchers will measure changes in pain levels, drug cravings, anxiety, and vital signs like heart rate…

This study is adapting a text-message chatbot named Penny to provide support for pregnant and new mothers who have opioid use disorder. The goal is to see if having a 24/7 text-based companion can help reduce feelings of loneliness and help women stay engaged in their healthcare.…

This study is testing whether taking methadone twice a day instead of once a day helps people better manage chronic pain while being treated for opioid addiction. It will involve 150 adults already receiving stable methadone treatment. Researchers will compare pain levels and tre…

This study is testing if a new oral medicine, BI 1356225, can help improve impulse control in adults with opioid addiction who are already taking buprenorphine treatment. About 60 participants will be randomly assigned to take either the new medicine or a placebo pill for 8 days …

This study is testing whether offering yoga or physical therapy classes directly at opioid treatment centers can help people who are dealing with both chronic back pain and opioid use disorder. Researchers will compare these two programs to usual care to see which one better redu…

This study aims to understand how social relationships and daily interactions affect treatment success for people with opioid addiction. Researchers will follow 100 patient-caregiver pairs for 12 weeks, using smartwatch apps and daily surveys to track social behaviors, medication…

This study aims to understand how brain function related to learning and memory might connect adverse childhood experiences to symptoms of opioid use disorder. Researchers will compare brain scans and memory task performance across three groups: people with opioid use disorder on…

This study aims to understand how opioid addiction affects brain function and thinking skills, and whether brain scans and thinking tests can predict who will do well in treatment. Researchers will study 192 adults with opioid addiction who are already on stable medication treatm…

This study aims to better understand how opioid use disorder during pregnancy affects both mothers and babies over time. Researchers will follow 200 mothers with opioid use disorder and 100 mothers without opioid use, tracking their babies' development for up to two years after b…

This study aims to understand how a parenting therapy program affects brain activity and thinking patterns in mothers recovering from opioid addiction. Researchers will enroll 15 mothers in treatment to complete brain scans and questionnaires before and after 12 therapy sessions.…

This study aims to understand why some pregnant women with opioid use disorder relapse and why some babies develop withdrawal symptoms, while others do not. Researchers will follow 100 pregnant women already receiving standard medication treatment and their infants for one year, …

This study aims to understand why some teenagers develop problems with opioid painkillers after surgery. Researchers will follow 20,000 teens and a parent for a year after a major operation to identify early warning signs. The goal is to gather information that could lead to bett…

This study aims to create a better tool for measuring opioid craving, which is a key factor in relapse for people with opioid use disorder. Researchers are recruiting 81 adults currently in treatment to understand their thoughts and feelings when shown opioid-related images and o…

This study aims to understand why people experience opioid withdrawal symptoms differently. Researchers will observe 60 adults with opioid use disorder during a medically supervised withdrawal process. They will measure symptoms and test a withdrawal medication to gather informat…

This small pilot study is testing whether a telemedicine support program is practical and helpful for people in Alabama who are living with HIV and also dealing with opioid or stimulant addiction. The goal is to see if remote healthcare visits can help connect this group to neede…

This study aims to understand how stress affects a person's response to opioid pain medication and their risk of misusing it. Researchers will enroll 120 adults with chronic back pain to measure their stress levels and then test their pain relief and feelings about the drug oxyco…

This study aims to understand and improve how emergency rooms across Canada care for people who have overdosed on opioids like fentanyl. Researchers will create a national registry by tracking the treatment and outcomes of 7,200 patients who come to the ER with an opioid overdose…

This study aims to understand how opioid addiction affects the brain by comparing brain scans of people with opioid use disorder to healthy volunteers. Researchers will use special imaging to look at cannabinoid receptors in the brain. The goal is to gather knowledge about brain …

This study aims to understand the physical signs of opioid withdrawal and cravings. Researchers will have 20 people with opioid use disorder wear smartwatch-like sensors during a 14-day detox program. The goal is to see if changes in heart rate, sweat, and other body signals matc…

This early study aims to understand how brain chemistry changes when people use both opioids and cocaine, and whether a dietary supplement called NAC can help. Researchers will enroll 24 adults who use both drugs and are not seeking treatment. They will measure brain activity and…