Brain pacemaker tested for opioid addiction that Won't quit

NCT ID NCT04354077

Recruiting now Disease control Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether deep brain stimulation (DBS) of the nucleus accumbens can help people with opioid use disorder who keep relapsing despite standard treatments. Only 3 participants will receive the implanted device. The main goal is to see if it is safe and whether it can help them stop using opioids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: deep brain stimulation device
What this could lead to: If it works, this could point toward a new treatment option for people with severe opioid addiction that hasn't responded to other therapies.
What could go wrong: This is a very early, tiny pilot study with only 3 people. It is designed mainly to check safety, not effectiveness. Brain surgery carries serious risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Behavior, Addictive opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER

Contacts and locations

Locations

AHN Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States

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