OPIOID USE DISORDER

This study tests a program called ED LINC, which provides coordinated care starting in the emergency department for people with opioid use disorder. The program helps patients get medications for opioid use disorder and reduces their drug use and emergency visits. About 500 adult…

This study tests whether a smartphone app that connects people recovering from opioid use disorder with peer support can help them stay in treatment and improve their recovery. About 1,300 adults who own a smartphone and are in recovery or treatment for opioid use will use the ap…

This early-phase study tests whether suvorexant, a sleep aid, can lower how much people with opioid use disorder want and use drugs. Researchers measure drug demand and sleep in 75 adults. The trial is currently suspended.

This study tests whether offering medication for opioid use disorder (MOUD) via telehealth, with or without a peer navigator, helps women in jail start and continue treatment after release. About 900 women in Kentucky jails will take part. The goal is to increase treatment initia…

This study looks at the best ways to add mental health care for depression into clinics that provide methadone treatment for opioid use disorder in Ukraine. About 1,350 patients from 12 clinics are taking part. The goal is to see if training doctors and offering small payments fo…

This study looks at whether using a smartphone app that gives rewards for drug-free saliva tests works for older adults with opioid, cocaine, or methamphetamine use disorders. Researchers will compare their results to younger participants to see if age affects how well the app wo…

This study tests two approaches to help people with chronic pain and opioid use disorder: telemedicine with collaborative management alone, or combined with a self-management program. About 259 adults will participate to see if these methods improve pain and reduce opioid misuse.…

This study looks at whether a team-based care model can help pregnant and postpartum women with opioid use disorder start and stay on medication, reduce overdoses, and keep their children out of foster care. About 1,350 women from three low-resource clinics in Pennsylvania will t…

This study tests whether giving a long-acting buprenorphine shot (BRIXADI) via telemedicine to 30 people in jail, just before they are released, helps them stay on treatment and avoid opioid use. Participants switch from daily sublingual buprenorphine to weekly and then monthly i…

This study tests a community program in Houston that combines outreach, medication, counseling, peer support, and paramedic follow-up to help people with opioid use disorder start and remain in treatment. About 3,000 adults who test positive for opioids and want to stop using wil…

This study compares standard emergency department care to an extended observation stay for people with untreated opioid use disorder. Researchers want to see if more time in the ED helps patients begin medication like buprenorphine and successfully connect to follow-up addiction …

This study looks at whether giving e-cigarettes to adults aged 50 and older who are in treatment for opioid use disorder can help them cut down on smoking. Participants are not trying to quit smoking. The study compares those who receive e-cigarettes to those who get brief advice…

This study tests a program where people with opioid or stimulant use disorders earn small cash rewards for attending clinic visits and providing drug-free urine samples. The goal is to see if this approach helps them stay in treatment and reduce drug use. The study involves 56 ad…

This study tests a program called MIAPP that helps people who use both opioids and methamphetamine stay connected to treatment after leaving the hospital. Participants receive a patient navigator, a smartphone app for medication check-ins, and small rewards for sticking with thei…

This study compares two long-acting injectable medications—extended-release naltrexone and extended-release buprenorphine—for people with opioid use disorder who are leaving jail. About 240 participants from Maryland jails will receive one of the two medications monthly for six m…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This study aimed to see if adding a high dose of psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine treatment could help people with opioid use disorder stay off illicit opioids and improve their quality of life. It planned to compare a high dose (30 …

This study tests a special counseling program for people in the Cherokee Nation who are starting medication-assisted treatment for opioid use disorder. The program aims to help patients stay in treatment, reduce drug-related harm, and strengthen cultural connections. About 136 ad…

This study tests a program called RETAIN, designed to help people with opioid use disorder stay on their medication after being hospitalized for serious infections from injecting drugs. The program offers check-ins and support to keep patients engaged in treatment. The goal is to…

This study tests a mobile app called KIOS to see if it helps people with opioid use disorder stay in treatment longer and use fewer opioids. About 116 adults in Texas who recently started medication for opioid use disorder will use the app or get standard care. The goal is to see…

This study tests a 24-week program that uses small rewards and extra support to help people with opioid use disorder who inject drugs stick with their daily HIV prevention pill (PrEP). About 526 participants will be followed for a year to see if the program improves medication ad…

This study tests whether a mobile peer support app can reduce loneliness and improve social connections for 90 adults with opioid use disorder recently released from jail or prison. Participants use the app to connect with recovery peers. The goal is to see if this digital tool h…

This study aimed to compare two approaches for managing pain after surgery in people taking buprenorphine for opioid use disorder: continuing their usual dose versus reducing it temporarily. The goal was to see which method better controls pain and reduces cravings or relapse. Ho…

This study tests a device called NET to see if it can reduce opioid withdrawal symptoms without using medication. About 108 adults who want to stop using opioids without drugs will try the device or a fake version. The goal is to see if the device helps with withdrawal and suppor…

This study tests a small device that gently stimulates a nerve in the ear to see if it helps people with both PTSD and opioid use disorder stick with their buprenorphine treatment. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will c…

This study tests whether a mobile mindfulness app can help people in treatment for opioid use disorder who also have a history of childhood trauma. About 60 participants will use the app daily for 30 days and visit the clinic four times to check stress levels through surveys, blo…

This study tests a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) for veterans with chronic pain who are also being treated for opioid use disorder. About 157 veterans will take part, comparing the new therapy to standard education …

This study aimed to compare two pain medicines given during spinal anesthesia for cesarean delivery in patients with opioid use disorder who take buprenorphine. It planned to enroll about 0 participants and measure pain scores and recovery over 36 hours. However, the study was wi…

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study tests two approaches to help people with opioid use disorder and chronic pain who are taking buprenorphine. One approach is a pain self-management program with coaching and peer support. The other allows patients to adjust their buprenorphine dose based on their pain l…

This study tests whether combining exercise (cycling) with psychotherapy can reduce drug cravings, depression, and anxiety in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will take part. The goal is to find better ways to manage both…

This study tests whether a 12-week Pain Self-Management (PSM) program helps people with chronic pain and opioid misuse or opioid use disorder (OUD) manage pain better and stay engaged in their OUD treatment. About 204 adults from primary care clinics will either take part in PSM …

This study looks at whether a simple breathing technique called heart rate variability biofeedback (HRVB) can help adults recovering from opioid use disorder. About 24 people in a residential treatment program will practice daily breathing exercises for 3 weeks using a portable d…

This study tests a new sublingual film (BXCL501) containing dexmedetomidine, a non-opioid drug, to reduce withdrawal symptoms in people with opioid use disorder. About 160 adults who are physically dependent on opioids will receive BXCL501, lofexidine, or a placebo during a 7-day…

This early-phase study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce physical and emotional withdrawal symptoms when people lower their methadone dose. About 36 adults in a supervised opioid treatment program will receive eith…

This early-stage study tests a smartphone app called NEAT-O that teaches coping skills to people with opioid use disorder who also have anxiety or depression. About 15 adults currently in medication treatment for opioid use will try the app for a few weeks. Researchers will check…

This study tests a treatment that combines two therapies—Acceptance and Commitment Therapy (ACT) and Mindfulness-Based Relapse Prevention (MBRP)—to help people with both chronic pain and opioid use disorder. About 160 adults already stable on buprenorphine will be randomly assign…

This study is testing a mobile app designed to teach pregnant women who are in treatment for opioid use disorder how to care for newborns at risk for Neonatal Abstinence Syndrome (NAS). The app aims to help mothers learn effective caregiving strategies before their baby is born. …

This study looks at how combining public health and medical data can help pregnant women with opioid use disorder get better care. The goal is to improve treatment and reduce risks like severe withdrawal in newborns. Ten pregnant women with opioid use disorder will be followed to…

This study looks at whether smartphone-based brain games can help measure and improve thinking skills in adults aged 55 and older who are receiving methadone treatment for opioid use disorder. Participants will play short, game-like tasks on a phone for 15 days to see if they fin…

This study looks at whether an online support program called HOPE can help people with opioid use disorder learn about and ask for medication treatment. Researchers will track how many participants request information or help scheduling an appointment. The study involves 640 adul…

This study looks at how opioid use disorder and the medication buprenorphine affect the brains of pregnant women. Researchers will compare brain scans of 40 pregnant women with and without opioid use disorder. The goal is to learn how the body processes the medication and how it …

This study involves 3,650 adults starting medication for opioid use disorder at 20 treatment clinics. Participants will use a tool to track their symptoms and share results with their providers. The goal is to see if this approach helps people stay in treatment longer and improve…

This study looks at why many veterans with PTSD, depression, or alcohol/opioid problems don't get proven treatments. It tests a method called Participatory System Dynamics, where patients, doctors, and leaders work together to improve care. The goal is to see if this approach wor…

This pilot study uses special PET scans to see where opioids bind in the brain and body of up to 60 adults, including some with opioid use disorder. Researchers aim to understand how opioid receptors work in different organs, which could help improve treatments. Participants may …

This study looks at 350 people with opioid use disorder to understand how social life, mental health, and body chemistry together affect addiction severity. Researchers will collect blood samples and detailed personal information to find patterns that could help predict the cours…

This study looks at how a brain stimulation technique called TMS affects decision-making in people with opioid use disorder and healthy volunteers. Participants will have brain scans and play computer games while receiving real or placebo TMS. The goal is to understand brain acti…

This study aimed to understand how patients and clinic staff feel about using long-acting injectable medications to treat both HIV and opioid use disorder together. Researchers planned to enroll about 40 participants, including patients and staff, to test a combined treatment app…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve treatment outcomes for people with opioid use disorder. Researchers will look at how stress affects drug cravings and decision-making. 32 adults on methadone or buprenorphine will receive …

This study tests a training program for prenatal healthcare providers to help them use proven treatments for opioid use disorder during pregnancy. Researchers will look at how the program affects the use of medication-assisted treatment and health outcomes for mothers and babies.…