OPIOID USE DISORDER

This study compares two long-acting injectable medications for people with opioid addiction who are leaving jail. 240 participants in Maryland jails will receive either monthly buprenorphine or naltrexone injections starting in jail and continuing for 6 months after release. Rese…

This study is testing a new way to improve care for people with opioid addiction. It involves patients regularly tracking their symptoms and recovery progress using simple tools, then discussing this information with their treatment providers. The goal is to see if this shared tr…

This study aimed to test a combined monthly injection treatment for people living with both HIV and opioid addiction. The goal was to see if giving both medications in one visit would make treatment easier and improve adherence. The trial was withdrawn before any participants wer…

This study is testing a support program for people leaving the hospital who are being treated for opioid addiction and also use methamphetamine. The program combines a patient navigator (a coach), a smartphone app for medication check-ins, and small rewards to help people connect…

This study is testing whether a mobile app that provides 24/7 access to anonymous, moderated peer support groups can help people recovering from opioid addiction. It aims to help participants build personal recovery resources, stay engaged in treatment, and reduce stress and isol…

This study is testing whether connecting women with opioid addiction to treatment providers via video call (telehealth) before they leave jail, sometimes with added support from a trained peer who is also in recovery, helps them start and stay in medication treatment after releas…

This study is testing different ways to provide depression treatment to people receiving addiction medication at methadone clinics in Ukraine. Researchers are comparing standard care against two telehealth approaches that connect clinic staff with mental health experts. The goal …

This study is testing if a medication called buspirone can help people with opioid addiction get through withdrawal more comfortably. One hundred adults will stay in a residential unit for 10-12 days to detox and will receive either buspirone, a different withdrawal medication (l…

This study is testing a new combined therapy for people who have both long-term chronic pain and an addiction to opioid painkillers. About 160 people already receiving standard medication treatment will try either the new therapy or continue with their usual care. The goal is to …

This is an early-stage study to test a smartphone app called NEAT-O. The app delivers a form of therapy (CBT) designed for people who have opioid addiction and also struggle with anxiety or depression. Researchers are testing if the app is easy to use and acceptable to 15 partici…

This study is testing whether a smartphone app that gives cash rewards for passing drug tests helps people with opioid, methamphetamine, or cocaine addiction stay clean. It specifically wants to see if the app works as well for adults aged 55 and older as it does for younger adul…

This study is testing if adding exercise and psychotherapy to standard drug treatment helps people with opioid addiction. It focuses on reducing drug cravings and managing chronic pain. The research involves 198 adults currently in a residential treatment program.

This small pilot study is testing whether providing e-cigarettes is a practical way to help adults aged 50 and older, who are in treatment for opioid addiction and currently smoke, switch from regular cigarettes. Participants are not trying to quit smoking. The study compares giv…

This study is testing a new, integrated care program called CADENCE for pregnant women with opioid use disorder. The goal is to use local health data to improve access to treatment and support services for mothers and their babies. Researchers hope this approach will lead to bett…

This study tests a training program for prenatal care doctors to help them better treat opioid addiction during pregnancy. The program provides education, remote support, and case management to help doctors use recommended medications. Researchers will measure if this training le…

This early-stage study is testing whether suvorexant, a medication approved for insomnia, might help people with opioid addiction by reducing their desire to use drugs. About 75 participants with opioid use disorder will stay in a hospital for about two weeks. They will receive e…

This study is testing whether a private, peer-led Facebook group can encourage more people with opioid addiction to ask for and start medication treatment. About 640 adults with moderate-to-severe opioid use disorder who are not currently on medication will be randomly placed int…

This study is testing if a reward program helps people with opioid or stimulant addiction stick with their treatment. Patients can earn small cash payments for attending their doctor's appointments and for having drug-free urine tests. The goal is to see if this approach, already…

This study is testing a telehealth therapy program designed to help veterans who are dealing with both long-term chronic pain and an opioid use disorder. It compares a special therapy that combines mindfulness and acceptance techniques against a standard education program. The go…

This study is testing whether a new support program started in the emergency room can help people with opioid addiction. The program provides education, motivation, help starting medication treatment, and three months of follow-up care. Researchers want to see if this approach he…

This study is testing a coordinated care program designed to help pregnant and postpartum women with opioid addiction in rural, low-resource areas. The program aims to help women start and stay on addiction medication, reduce overdose risk, and lower the chance of children being …

This study compares two ways to help people recently released from jail or prison get connected to important health services. It focuses on HIV prevention and treatment, hepatitis C care, and medication for opioid addiction. Researchers will test whether personal guides or mobile…

This program aims to help people with opioid addiction by quickly connecting them to treatment after an overdose or emergency room visit. It combines medication, counseling, peer support, and follow-up care. The goal is to see if this coordinated approach helps people start and s…

This study compares two telehealth support programs for adults with chronic pain who are on long-term opioid therapy. It tests whether adding a virtual self-management coaching program to a standard pharmacist-led care model is more effective. The goal is to help people better ma…

This study explores whether a non-invasive brain stimulation technique called rTMS can help people with opioid addiction who are starting methadone treatment. Researchers are testing if stimulating specific brain areas can improve patients' ability to handle stress and control cr…

This study is testing a mobile app designed to teach pregnant women with opioid use disorder how to care for their newborns who are at risk for Neonatal Abstinence Syndrome (NAS), a set of withdrawal symptoms. The goal is to see if the app is easy to use and helpful for mothers, …

This study compares two ways emergency departments can help people with opioid addiction. It tests whether a standard emergency visit or a longer observation stay works better to start medication treatment and connect patients to ongoing care. Researchers are measuring how many p…

This study compares three team-based care models for adults with opioid addiction who also have depression, anxiety, or PTSD. Researchers want to see which combination of doctors, mental health managers, and recovery specialists works best in regular primary care clinics. The goa…

This study is testing whether a small earpiece that delivers gentle nerve stimulation can help people who have both post-traumatic stress disorder (PTSD) and opioid addiction stick with their medication treatment. About 20 participants will use the device for 12 weeks alongside s…

This study aimed to see if a single, guided session with the psychedelic compound psilocybin (found in 'magic mushrooms') could improve outcomes for people starting standard medication treatment (buprenorphine) for opioid addiction. Participants would have received either a high …

This study aims to prevent opioid overdoses by testing if support from a pharmacist is more effective than a counselor for people with opioid addiction who are leaving jail. Participants receive training on how to use the overdose-reversal drug Narcan and counseling to help them …

This study is testing two ways to help people who are being treated for opioid addiction and also have severe chronic pain. Researchers are comparing pain coaching sessions and a flexible medication dosing plan against usual care. The goal is to see if these approaches help reduc…

This study is testing a new, non-opioid medication to help people get through opioid withdrawal. It compares a new under-the-tongue film (BXCL501) to an existing medication (lofexidine) and a placebo. The goal is to see if the new option is safer and works better at reducing with…

This study aimed to find the best way to manage pain after surgery for people taking buprenorphine for opioid addiction. Researchers planned to compare continuing the full medication dose versus temporarily lowering it around surgery time. The goal was to see which approach bette…

This study is testing whether a daily mindfulness app can help people who are in treatment for opioid addiction and who also experienced trauma as children. Researchers want to see if participants will use the app and if it helps lower their stress levels. The study involves 60 p…

This study aimed to find the best spinal pain medication for women with opioid use disorder who are taking buprenorphine and have a cesarean section. It planned to compare two different pain drugs given during the spinal block to see which provided better pain control after surge…

This study is testing whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help reduce withdrawal symptoms when people try to lower their methadone dose for opioid addiction. It will compare two different pressure levels against a fake treatment …

This small pilot study is testing whether a daily breathing exercise program, guided by a portable heart rate monitor, is practical and helpful for adults in a residential treatment program for opioid addiction. The main goal is to see if participants can stick with the program a…

This study is testing whether a device that delivers a mild electrical current behind the ears can help reduce the symptoms of opioid withdrawal. It involves 108 adults with opioid use disorder who want to stop using opioids without taking other medications. Participants use the …

This study aims to understand how a non-invasive brain stimulation technique called TMS affects decision-making, particularly in people with opioid use disorder. Researchers will compare 60 participants—some with opioid use disorder and some healthy volunteers—using brain scans a…

This study aims to understand how opioid receptors work in the brain and body by using special scans. It will enroll up to 60 adults, including healthy people and those with opioid use disorder, some of whom are on treatment. The main goal is to gather knowledge, not to test a ne…

This study aims to understand how opioid use disorder (OUD) and its treatment medication affect the brain during pregnancy. Researchers will use MRI scans to compare brain connections in 40 pregnant women with OUD to those without OUD. The goal is to gather knowledge that could o…

This study is testing whether older adults (age 55+) receiving methadone treatment for opioid addiction can use brief, game-like smartphone tasks to measure their memory and focus. Over 15 days, 30 participants will complete short daily brain games to see if this remote approach …

This French study aims to better understand what makes opioid addiction more or less severe by observing 350 people with the disorder. Researchers will combine interviews about life experiences and social factors with blood tests looking for biological markers. The goal is to see…