OPIOID USE DISORDER

This study will test whether using opioid-free anesthesia during knee replacement surgery can reduce the risk of long-term opioid use and chronic pain. About 700 adults scheduled for knee replacement will be randomly assigned to receive either standard opioid-based anesthesia or …

This pilot study aimed to help people who had an opioid overdose by starting them on buprenorphine/naloxone in the emergency room and then connecting them to an addiction clinic. The goal was to reduce repeat overdoses and improve treatment engagement. However, the study was with…

This study tests whether an app that gives financial rewards for drug-negative saliva tests works for older adults with opioid, cocaine, or methamphetamine use disorder. Researchers will compare results between older and younger participants to see if age affects how well the app…

This study tests a new approach to help people recovering from opioid use disorder avoid relapse. About 90% of people in treatment relapse within a year. Researchers will use a gentle, non-invasive brain stimulation method called tDCS combined with cognitive training to see if it…

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This study tests whether adding peer recovery support—coaching from someone who has personally overcome opioid addiction—to standard medication treatment (buprenorphine) helps people stay in care longer. Fifteen adults with opioid use disorder will receive peer support for 180 da…

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This study tests whether a smartphone app can help people who are already on methadone treatment cut down on opioid and cocaine use. The app asks participants to take random drug tests at home and rewards them with money for negative results. Researchers want to see if app users …

This study tests whether a collaborative care model—where a nurse care manager works with your primary care doctor and an addiction specialist—can help adults reduce their use of opioids, stimulants (like cocaine or meth), and heavy drinking. About 300 patients from primary care …

This study compares two long-acting injectable medications—extended-release naltrexone and extended-release buprenorphine—for people with opioid use disorder who are leaving jail. 240 participants from Maryland jails will receive monthly shots for six months after release. The go…

This study tests whether adding culturally-aligned activities and healing groups to standard medication-assisted treatment (MAT) helps people with opioid use disorder stay in treatment longer and reduce harm. About 136 adults newly enrolled in the Cherokee Nation MAT program will…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This study tests whether giving a long-acting buprenorphine shot (BRIXADI) via telemedicine to 30 jailed adults with opioid use disorder helps them stay on treatment after release. Participants switch from daily pills to weekly or monthly shots before leaving jail, then continue …

This study tests a mobile app called KIOS that gives personalized advice and support to people receiving medication-assisted treatment for opioid use disorder. Over 12 weeks, 116 participants will either use the app plus standard counseling or just standard counseling. The goal i…

This study aimed to see if adding a single high dose of psilocybin (30 mg) to standard buprenorphine treatment could help people with opioid use disorder stay off illicit opioids and improve their quality of life. It planned to enroll adults aged 21–70 who were not already on opi…

This study looked at whether giving a short-term buprenorphine treatment to people on probation or parole with opioid use disorder helps them stop using illegal opioids and get into long-term care. About 320 adults in Baltimore took part. The approach was compared to simply refer…

This study compares two telemedicine approaches for people with chronic pain and opioid misuse. One program provides standard medication management via remote visits, while the other adds a 12-week self-help program with phone-based coaching. The goal is to see which approach bet…

This study tests whether a smartphone app that connects people in recovery from opioid use disorder with peer supporters can help them stay on track. About 1,300 adults who own a smartphone and are in recovery or treatment will use the app or receive usual care. Researchers will …

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This study compares standard emergency department care to an extended observation period for people with opioid use disorder. Participants are randomly assigned to either leave after a regular ED visit or stay longer in an observation unit to receive their first dose of buprenorp…

This study aimed to compare two ways of managing pain after surgery in people taking buprenorphine for opioid use disorder. One group would continue their usual dose, while the other would receive a lower dose around the time of surgery. The goal was to see which approach better …

This study tests a program called ED-LINC that starts in the emergency room for people with opioid use disorder. The program offers overdose education, motivation to seek help, help choosing medication, and three months of follow-up care. Researchers want to see if this approach …

This study tests a program that connects pregnant women with opioid use disorder to a team of doctors, peer supporters, and community resources like doulas and home visiting. The goal is to improve treatment during pregnancy and reduce the need for medication in newborns experien…

This study tests a team-based care model for pregnant and postpartum women with opioid use disorder in low-resource clinics. About 1,350 participants will receive coordinated support to start and stay on medication, reduce overdose risk, and improve well-child visits. The goal is…

This study tests a program called HEROES that combines medication (Suboxone), counseling, and community outreach to help people with opioid use disorder engage and stay in treatment. Researchers will enroll 3,000 participants in Houston to see if this approach improves treatment …

This study tests whether offering small monetary rewards can help people with opioid and stimulant use disorders stay in treatment and avoid drug use. Fifty-six adults starting medication for opioid use disorder at a family medicine clinic will earn incentives for attending appoi…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This study looks at whether a mobile mindfulness app (Headspace) can help people being treated for opioid use disorder who also have a history of childhood trauma. Sixty participants will be asked to use the app daily for 30 days and visit the clinic four times to check stress le…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This early-stage trial tests whether a daily tablet called BI 1356225 can improve impulse control in people with opioid use disorder who are already taking buprenorphine. About 60 participants will be randomly assigned to receive either the study drug or a placebo for 8 days. Res…

This study tests whether an adapted version of Cognitive Processing Therapy (CPT), delivered via telehealth at syringe service programs, can reduce PTSD symptoms and help people stay on their opioid use disorder medication. Eleven adults who regularly use syringe services and are…

This study tests a 12-week Pain Self-Management (PSM) program for people with chronic pain and opioid misuse or opioid use disorder. Researchers want to see if the program helps participants manage pain better and stay in treatment for opioid use. About 204 adults from primary ca…

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study tests a new sublingual film called BXCL501 (dexmedetomidine) to reduce the unpleasant symptoms of opioid withdrawal, like anxiety, muscle pain, and nausea. About 160 adults with opioid use disorder will receive the drug, a placebo, or an existing medication (lofexidine…

This study tests whether stationary cycling (at a voluntary or assisted pace) and a type of psychotherapy called I-STOP can reduce drug cravings in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will try these approaches alone or toget…

This study adapts a proven PTSD therapy (STAIR-NT) for people in methadone treatment who also use cocaine and opioids. Researchers will test if the adapted program is practical and acceptable, and whether it reduces substance use and PTSD symptoms. About 80 participants will be r…

This study aimed to compare two pain medicines given into the spinal fluid during C-section for patients with opioid use disorder who take buprenorphine. It planned to enroll about 0 participants and measure pain scores and recovery. However, the trial was withdrawn before any pa…

This study tests two approaches to help people with opioid use disorder and chronic pain feel better. One is a pain self-management program with coaching and peer support. The other allows flexible dosing of buprenorphine based on pain levels. 268 adults from participating clinic…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This study tests whether a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) can reduce how much pain interferes with daily life in veterans who have both chronic pain and opioid use disorder. About 157 veterans taking buprenorphine fo…

This study tests a treatment that combines two therapies (ACT and MBRP) to help people with both chronic pain and opioid use disorder. About 160 adults already on buprenorphine will be randomly assigned to either this combined therapy or their usual care. The goal is to see if th…

This study tests a device called NET that uses mild electrical stimulation to reduce opioid withdrawal symptoms. It involves 108 adults who want to stop using opioids without taking other medications. Participants are randomly assigned to get real or sham device treatment, and re…

This study looks at whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder and healthy volunteers make risky or uncertain decisions. Participants will have MRI scans and computer tasks, and some will receive real or sham TMS. The goal is to…

This study examines a program in two Boston-area jails designed to make HIV testing and treatment easier for people with opioid use disorder. Researchers will follow about 59 participants who are leaving jail within a month to see if they use HIV services, get tested, or take PrE…

This study tests a new interview tool called the Opioid Timeline Follow-Back (OpiTLFB) to better track nonmedical opioid use, including fentanyl. Thirty adults who use opioids at least once a week will fill out a calendar and answer questions about their drug use over the past 30…

This study looks at how to improve opioid court programs in New York State. Researchers will work with court staff and treatment providers to help defendants quickly get medication for opioid use disorder. The goal is to see if these strategies increase treatment retention, reduc…

This study aims to validate two new tools that use artificial intelligence to predict a person's risk of developing opioid use disorder. One tool looks at genetic markers, and the other examines gut bacteria. Researchers will enroll 300 adults with or without opioid addiction to …

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study follows 1600 adults with opioid use disorder over the long term by collecting monthly online surveys and yearly phone interviews. Researchers will track substance use, mental health, treatment involvement, and daily functioning. The goal is to better understand how peo…

This study looks at whether a mobile peer support app can help people who have been in jail or prison and are recovering from opioid use disorder feel more connected and less lonely. About 90 adults who recently took medication for opioid use disorder while incarcerated will use …

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This pilot study will use special PET scans to measure opioid receptor binding in the brain, spinal cord, and other organs in up to 60 adults, including healthy volunteers and people with opioid use disorder. The goal is to better understand how opioids affect the whole body, not…

This study tests whether an online support program called HOPE can help people with opioid use disorder ask for medication treatment. Researchers will assign 640 participants to either the HOPE online community or a control group and track how many request information about medic…

This study aims to understand why some people with opioid use disorder have more severe addiction than others. Researchers will collect blood, saliva, and hair samples from 350 participants and combine that with detailed interviews about their social and mental health. The goal i…

This study aimed to understand how patients and clinic staff feel about using long-acting injectable medications to treat both HIV and opioid use disorder together. Researchers planned to enroll 30 patients and 5-10 staff, giving patients the combined injections and following up …

This study is developing and testing a mobile app to teach pregnant women with opioid use disorder how to care for newborns who may experience neonatal abstinence syndrome (NAS). The app provides training on comforting techniques like swaddling, skin-to-skin contact, and feeding.…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people with opioid use disorder stick with their methadone treatment and avoid relapse. Researchers will measure how stress affects cravings and decision-making. 32 adults currently in methad…

This study uses a special imaging scan (PET/CT) and a radioactive tracer to measure inflammation in the brain. Researchers will compare four groups: people with HIV and opioid use disorder, people with only one of these conditions, and healthy volunteers. The goal is to understan…

This study involves 3,650 adults in 20 opioid treatment programs who are starting medication for opioid use disorder. Participants will use digital tools to track their symptoms and share results with their providers. The goal is to see if this approach helps people stay in treat…

This early study is testing whether focused ultrasound, a non-invasive technique that uses sound waves to target specific brain areas, is safe and feasible for people with opioid or other substance use disorders. The study involves 20 adults aged 22-60 who are currently in treatm…