Could a longer ER stay help more people start opioid addiction treatment?

NCT ID NCT05064826

Ongoing Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares standard emergency department care to an extended observation period for people with opioid use disorder. Participants are randomly assigned to either leave after a regular ED visit or stay longer in an observation unit to receive their first dose of buprenorphine and get a warm handoff to follow-up care. The goal is to see if the extended approach increases the number of people who start medication and stay engaged in treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: buprenorphine (BUP)
What this could lead to: If successful, this could show that keeping people in the ED for observation helps them start addiction medication and connect to follow-up care more reliably.
What could go wrong: This is a mid-stage trial with 170 participants, so results may not apply to all settings. The main focus is on starting treatment, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOD USE DISORDER OPIOID-USE DISORDER

Contacts and locations

Locations

Bellevue

New York, New York, 10016, United States
NYULH-Brooklyn

Brooklyn, New York, 11220, United States
NYULH-Tisch

New York, New York, 10016, United States
Northwell Health - Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States
Northwell Health - Staten Island University Hospital

Staten Island, New York, 10305, United States
Rutgers University-University Hospital

Newark, New Jersey, 07103, United States

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