OPIOID USE DISORDER

This study tests whether completing methadone clinic intake while still in the hospital helps people with opioid use disorder stay connected to treatment after they leave. About 1,440 adults will be enrolled across four hospitals. The goal is to reduce the high risk of relapse an…

This study explores whether emergency medical services (EMS) can safely start buprenorphine treatment for people with opioid use disorder right at the scene of an emergency. Researchers will first test how feasible and acceptable this approach is, then measure how many patients s…

This study compares two ways of giving buprenorphine (a medication for opioid use disorder): through telemedicine (video calls and mailed medication) versus standard in-person care. About 50 adults with opioid use disorder will be randomly assigned to one of the two groups. The m…

This study tests whether a set of strategies to improve coordination between emergency departments and outpatient clinics helps people with opioid use disorder stay on buprenorphine longer. About 3,500 adults who start buprenorphine in the ER will be followed for up to 12 months.…

This study tests an implant called iSTEP-N that releases naltrexone over many months to block the effects of opioids. It involves 33 healthy adults aged 18 to 55 who will receive either a low-dose or high-dose implant or monthly Vivitrol injections. The goal is to see if the impl…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their regular addiction medication appointments in one visit. The goal is to make it easier for veterans to get tested and treated for infections …

This study tests a text- and web-based tool called FamilyCHESS, designed for people with opioid use disorder and a loved one (like a parent or partner). The goal is to see if the tool helps patients begin and continue taking medication for opioid use disorder. About 338 participa…

This study tests a new approach to restarting methadone treatment for people with opioid use disorder who use fentanyl. Current guidelines often require slow dose increases, which can delay relief. The new method may allow patients to return to their previous stable dose more qui…

This study aims to develop and test a telehealth program to help people with opioid use disorder get treatment with buprenorphine. Researchers will enroll 60 adults, half already in treatment and half not yet in treatment, to receive care via video or phone. The goal is to see if…

This study tests the safety of a long-acting naltrexone implant (OLANI) in 250 adults with opioid use disorder who want to avoid relapse. The implant releases medication slowly to block opioids' effects, helping patients focus on recovery. Participants receive up to four implants…

This study compares two strategies for starting buprenorphine treatment in adults with opioid use disorder who use fentanyl. Participants will be randomly assigned to either a low-dose initiation or a direct-to-inject protocol. The goal is to see which approach helps people stay …

This study tests whether personalized treatment plans, guided by machine learning, can improve care for people with opioid use disorder. Researchers will enroll 75 adults receiving care at behavioral health centers. The goal is to find the best sequence of treatments to lower ove…

This study tests a program for people with opioid use disorder who have had an overdose. After leaving the emergency room, participants get telehealth visits, a peer support specialist, and medication (buprenorphine) to help them stay in treatment. The goal is to reduce repeat ov…

This study tests whether offering medication for opioid use disorder (buprenorphine) in nonmedical community settings, along with coaching, helps people stay in treatment longer than standard clinic-based care. About 400 participants will receive either the community-based model …

This pilot study will see if giving monthly extended-release buprenorphine injections from a mobile pharmacy clinic is acceptable and practical for people with opioid use disorder. Sixty adults who want to start this treatment will receive injections for 6 months. The main goal i…

This study tests a program called CROSSROADS for people who recently survived an opioid or stimulant overdose. Participants get either standard paramedic follow-up or that plus help with legal issues like housing or benefits. Researchers will track drug use and contact with the l…

This study will test whether a comprehensive telehealth platform called RecoveryPad helps adults with moderate to severe opioid use disorder get their first buprenorphine prescription faster. About 470 participants will be enrolled. The goal is to see if using the platform leads …

This study tests whether offering gift cards for attending appointments can help people leaving jail stay on their opioid addiction medication. Participants earn up to $600 over three months for sticking with treatment. The goal is to reduce the high risk of overdose after releas…

This study tests whether adding mindfulness training to ketamine-assisted therapy helps people with opioid use disorder who are already on medication. About 88 adults will be randomly assigned to receive either the combined treatment or ketamine therapy with a support group. Rese…

This study will test a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risk. About 200,000 patients will be involved, and researchers will compare …

This study tests whether long-acting HIV prevention shots and opioid use disorder medications work well for people in prison who are close to release. About 300 adults will receive these treatments and be followed to see how well they stick with them and whether they reduce HIV r…

This study works with 300 women in Kentucky jails who have opioid or stimulant use disorder. The goal is to lower their risk of overdose when they return to rural communities after release. The program offers support and connects them to treatment options during this high-risk tr…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with opioid or alcohol use disorder reduce cravings, withdrawal symptoms, and improve engagement in therapy. Sixty adults enrolled in an intensive outpatient rehab program will receive …

This pilot study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction better manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also at…

This study tests whether two FDA-approved cannabis-based drugs, dronabinol and epidiolex, can help people with opioid use disorder who have just started buprenorphine treatment. The goal is to see if these drugs can reduce withdrawal symptoms and opioid use, helping patients stay…

This study looks at two pain medicines, buprenorphine and oxycodone, to see which works better and is safer for people with serious injuries. About 282 adults with injuries to at least two body parts will take part. The goal is to improve pain control while reducing the risk of o…

This study tests whether a ketone supplement taken three times daily for seven days can lower opioid cravings and ease withdrawal symptoms like low mood and pain in adults with opioid use disorder. Fifty participants in an inpatient detox program will receive either the supplemen…

This study tests a digital treatment program that veterans with opioid use disorder and chronic pain can use at home. The goal is to see if it helps reduce how much pain interferes with daily life and improves overall function. About 250 veterans who are already on buprenorphine …

This study tests whether a computer alert that reminds doctors about treatment options can increase the use of medications for opioid use disorder. About 200,000 patients will be involved, with some doctors getting the alert and others not. The goal is to see if the alert leads t…

This study looks at how a type of brain stimulation (rTMS) and a stress-inducing drug affect thinking, cravings, and stress responses in people with opioid use disorder who are not seeking treatment. Researchers will measure things like memory, decision-making, and biological str…

This study looks at whether using no opioids during knee replacement surgery can help prevent patients from becoming dependent on painkillers later. About 700 adults having elective knee surgery will be randomly assigned to receive either opioid-free or standard opioid anesthesia…

This study looks at whether recent federal policy changes made it easier for veterans with opioid or alcohol use disorder to get and stay on medication-assisted treatment. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using da…

This study tests a new program that helps people receiving medication for opioid use disorder connect with recovery community centers. Researchers will enroll 145 adults in Massachusetts to see if the program is feasible, acceptable, and helpful. The goal is to improve recovery o…

This study tests whether an 8-session telehealth program can help people who inject drugs in rural areas build coping skills and resilience. The goal is to make it easier for them to access HIV prevention (PrEP) and hepatitis C care. The study involves 50 participants and will me…

This study looks at whether a special training and coaching program for supervisors (called COSTARS) can help keep caseworkers and peer mentors in their jobs longer and improve services for families. About 200 supervisors from Ohio child welfare agencies will either take part in …

This study tests whether an AI tool called Compl-AI can predict which adults with opioid use disorder are likely to stop their medication early. Researchers will observe 295 people receiving their usual treatment and track medication visits and adherence. Participants complete a …