OPIOID USE DISORDER

This study is testing whether a telehealth platform called RecoveryPad can help adults with moderate to severe opioid addiction. Researchers want to see if using this digital tool helps people get medication treatment faster and reduces overdose events. The study will enroll 470 …

This study is testing whether a mobile pharmacy clinic can effectively provide a monthly injection for opioid addiction. The injection, called BRIXADI, is a long-acting form of buprenorphine. Researchers will enroll 60 people to see if this mobile delivery method is practical and…

This study tests whether a computer alert system helps primary care doctors better identify and treat patients with opioid use disorder. The system reminds doctors to use a treatment pathway that includes medications like buprenorphine. Researchers will track whether the alerts l…

This study tests whether a rewards program can help people continue their opioid addiction medication after being released from jail, when overdose risk is highest. Up to 75 participants who are already receiving treatment in jail can earn gift cards—up to $600 over three months—…

This study is testing a 9-week online program designed to help veterans who have both chronic pain and opioid addiction. The program provides personalized weekly feedback and daily check-ins to help manage pain and support recovery while participants continue their standard medic…

This study aims to test whether a new set of support strategies helps people who start medication for opioid addiction in the emergency room continue their treatment with an outpatient doctor. It will involve nearly 3,500 adults and will track if they stay on their prescribed med…

This study aims to see if a special therapy program helps women with opioid addiction and a history of partner violence stay in their medication treatment longer. It compares a new stepped-care approach, which offers different levels of therapy based on need, to standard treatmen…

This study is testing a new method to help people with opioid addiction start taking medication to manage their condition. The method involves carefully giving a small dose of a reversal drug (naloxone) to trigger mild withdrawal, then quickly giving the treatment medication (bup…

This study is testing the safety of a biodegradable implant that slowly releases naltrexone, a medication that blocks the effects of opioids. The implant is placed under the skin of the abdomen and is designed to help people with opioid addiction stay in recovery by preventing re…

This study is testing whether Emotional Brain Training (EBT), a method that teaches skills to shift from negative to positive emotional states, can help people in addiction recovery. Researchers will compare standard addiction treatment alone to standard treatment plus 8 weeks of…

This study is testing whether adding a specific mindfulness training program to ketamine-assisted therapy helps people with opioid addiction who are already on medication treatment. Researchers want to see if this combination reduces opioid use and cravings better than ketamine t…

This study is testing whether a non-invasive brain stimulation technique, called Transcranial Magnetic Stimulation (TMS), can help people with opioid or alcohol addiction. It will see if adding TMS to standard rehab therapy helps people stay engaged in treatment, reduces cravings…

This study is testing a new implant called iSTEP-N, which is placed under the skin and slowly releases a medication (naltrexone) to block the effects of opioids. The goal is to see if this implant can maintain protective drug levels for many months, potentially offering an altern…

This study tests whether treating opioid addiction through video calls works as well as traditional in-person clinic visits. 50 people with opioid addiction will receive buprenorphine medication either through telemedicine or at a clinic for 12 weeks. Researchers will compare how…

This study is testing whether two FDA-approved cannabis-based medications, dronabinol (THC) and Epidiolex (CBD), can help people with opioid addiction stay in treatment and reduce their opioid use. It focuses on people who have recently started buprenorphine, a standard addiction…

This study aims to find the best way to start buprenorphine, a medication for opioid addiction, in people who use fentanyl. It will compare two methods: a slow, low-dose start versus a direct injection. Researchers will track 50 participants for 90 days to see which approach help…

This study tests if paramedics can safely start a medication called buprenorphine for people with opioid addiction during emergency calls. Researchers want to see if this early help makes it easier for people to get into longer-term treatment. The study will first check if the pa…

This study tests a bundled support program for people who have survived an opioid overdose and visited the emergency department. The program combines telehealth check-ins, peer support, medication (buprenorphine), and help connecting to long-term care. Researchers want to see if …

This small pilot study is testing whether mailing buprenorphine medication directly to patients' homes helps people with opioid addiction stay in treatment after leaving the hospital. The research aims to overcome common barriers like transportation problems and pharmacy access. …

This study is testing a new program called CROSSROADS for adults who recently survived a drug overdose and were seen by community paramedics. It compares standard paramedic care to an enhanced program that also provides free legal help for issues like housing or benefits that can…

This study is testing personalized treatment plans for people with opioid addiction. Researchers will use computer algorithms to create customized treatment sequences that may reduce overdose risk and improve recovery. The study will involve 75 adults receiving care at behavioral…

This study is testing whether an 8-week telehealth program is practical and helpful for people who inject drugs in rural areas. The program focuses on building coping skills and resilience to help participants manage stress and stigma, with the goal of improving their access to H…

This study is testing a text and web-based support tool designed for a person with opioid addiction and a close family member or friend. The goal is to see if this digital tool helps the person start medication treatment for their addiction and stick with it longer. Researchers w…

This study is developing and testing a telehealth program designed to make treatment for opioid addiction more accessible, especially for underserved groups. It will involve 60 participants, some already in treatment and some just starting, to see if remote care can help people s…

This study is testing whether a new community-based support model helps people stay in medication treatment for opioid addiction longer. It will compare two approaches: standard clinic care versus clinic care combined with telemedicine and a personal recovery coach at a local com…

This study is testing a new way to provide care for veterans with opioid addiction. It combines addiction treatment with screening and prevention for serious infections like HIV and hepatitis C into a single clinic visit. The goal is to make it easier for veterans to get all the …

This study is testing a new support program for people taking medication for opioid addiction. It aims to actively connect them with local community recovery centers to provide extra support. Researchers will compare this new approach to standard care in a small pilot trial with …

This study aims to prevent HIV infections and help manage opioid addiction for people transitioning from jail back to the community. Researchers will test whether long-acting injection treatments work better than daily pills at keeping people on their medications. The study invol…

This study aims to prevent chronic opioid use after surgery by testing opioid-free anesthesia during knee replacement operations. Researchers will compare patients receiving opioid-free anesthesia with non-opioid pain relief against those receiving traditional opioid-based anesth…

This study tests whether a computer tool helps doctors follow safe guidelines when reducing patients' opioid painkiller doses. The tool provides recommendations to prevent withdrawal symptoms and overdose risks during medication tapering. Researchers will track 200,000 patient re…

This study tests different support programs to prevent drug overdoses among women with substance use disorders as they transition from jail back to rural Kentucky communities. Researchers will compare recovery coaching alone versus coaching combined with support from a personal c…

This study compares two pain management approaches for adults with serious injuries. Researchers want to see if using buprenorphine (a medication sometimes used for opioid addiction) works as well as traditional oxycodone for controlling pain after trauma. The goal is to find eff…

This study is testing whether a ketone supplement drink can help reduce cravings and ease withdrawal symptoms for people with opioid use disorder. Fifty adults starting inpatient withdrawal treatment will take either the ketone drink or a placebo three times a day for a week. Res…

This study aims to understand how stress affects thinking and drug-seeking behavior in people with opioid use disorder. Researchers will test whether a non-invasive brain stimulation technique can improve mental control and reduce reactions to stress. The study involves 20 partic…

This research tests different ways to help opioid treatment programs keep patients in care longer. The study will compare two quality improvement approaches—providing clinics with performance data and improvement tools, with or without extra coaching—against usual care practices.…

This study aims to see if a computer model called Compl-AI can accurately predict which patients are likely to stop their medication for opioid addiction early. Researchers will observe about 295 adults already receiving standard treatment in community programs. The study will no…

This study aims to understand if recent federal policy changes made it easier for veterans to get and stay in treatment for opioid addiction. Researchers will compare health records from before and after the policy changes for over 185,000 veterans with opioid or alcohol use diso…

This study aims to see if a special training and coaching program for supervisors helps keep staff in their jobs and improves services for families. It will involve 200 supervisors from Ohio's child welfare agencies who work with families affected by substance use. Researchers wi…

This study aims to understand how people with opioid addiction cope with stress. Researchers will test 125 participants with opioid use disorder by measuring their thinking, emotions, and sense of control during both stressful and non-stressful situations. The goal is to create b…